Clinical trials: Aspirin
Pre-Eclampsia
Indonesia Pravastatin to Prevent Preeclampsia Study
BACKGROUND Preeclampsia is a major cause of maternal and neonatal morbidity worldwide. There is currently no cure for preeclampsia, the only definitive treatment is termination of pregnancy by induction of labour or caesarean…
- Trial name
- INOVASIA (NCT03648970)
- Testing
- Pravastatin
- Where
- 7 sites in Indonesia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Vascular Surgery Patient With PAD / Carotid Stenosis
Perioperative Aspirin Response in Patients Undergoing Vascular Surgery
Reduced antiplatelet activity (low response (LR)/high on-treatment platelet reactivity (HPR)) of aspirin (ALR) or clopidogrel (CLR) is associated with an increased risk of thromboembolic events.
- Trial name
- NCT03587324
- Testing
- Whole blood aggregometry before and after vascular treatment (ASA/ Clopidogrel).
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- St. Josef Hospital Bochum
Undifferentiated Connective Tissue Disease, Recurrent Pregnancy Loss
Immunosuppressant Regimens for Living Fetuses Study
Undifferentiated connective tissue diseases (UCTD) are known to increase the risk of pregnancy morbidities, including recurrent pregnancy loss.
- Trial name
- NCT03671174
- Testing
- Prednisone, Hydroxychloroquine, Aspirin
- Where
- China
- Volunteers
- 420 people
- Sponsor
- RenJi Hospital
Atrial Fibrillation, Intracardiac Thrombus
Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS)
This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus.
- Trial name
- LYSIS (NCT06141538)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pre-term Birth
Efficacy and Safety of Aspirin and Lansoprazole for Prevention of Preterm Birth in High-Risk Pregnant Women: A Biomarker-Enriched Trial
This protocol describes a seamless Phase II/III, randomized, double-blind clinical trial evaluating the efficacy and safety of daily low-dose aspirin (81 mg) plus lansoprazole (30 mg) in pregnant individuals at high risk for…
- Trial name
- NCT07337655
- Testing
- Low-Dose Aspirin Dose: 81 mg & Lansoprazole Dose: 30 mg, Standard of Care
- Where
- United States
- Volunteers
- 670 people
- Sponsor
- Stanford University
HIV-1 Infection
Modulation of Immune Activation by Aspirin
Since people started taking HIV medications, illness from AIDS has decreased, but other serious diseases like heart disease, cancer, and kidney, and liver disease have increased.
- Trial name
- NCT02155985
- Testing
- Aspirin
- Where
- 15 sites in United States
- Volunteers
- 121 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Cardiac Disease
Triple Antithrombotic Therapy in Cardiac Patients Requiring Revascularization
Aim(s)/Objective(s) To evaluate the safety and efficacy of triple antithrombotic therapy in patients taking DAPT of aspirin and a P2Y12 inhibitor in addition to either a NOAC or warfarin for the prevention of thromboembolic or…
- Trial name
- NCT03889574
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Methodist Health System
Atherosclerotic Cardiovascular Disease
A Study for Exploring the Efficacy of Naoxintong Capsules in the Treatment of Coronary Atherosclerotic Plaque on the Basis of Optimal Medical Therapy (Aspirin,Statins,Clopidogrel, Etc.): Stage One
To evaluate and compare the change of plaque composition by VH-IVUS imaging in subjects who take NXT and placebo in post-PCI of AMI patients during 12 months follow-up.
- Trial name
- NXT-ASSESS (NCT05278182)
- Testing
- Naoxintong Capsule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypertrophic Obstructive Cardiomyopathy
Mobilization of Endothelial Progenitor Cells and Aspirin
Aspirin at doses used during acute myocardial infarction may inhibit the mobilization of endothelial progenitor cells (EPCs).
- Trial name
- TROPHIC 3 (NCT02674958)
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Diabetes, Diabetic Retinopathy
Retinal Blood Flow and Microthrombi in Type 1 Diabetes
The project aims to find mechanisms for the abnormal retinal blood flow that in diabetic patients often precedes any evidence of clinical retinopathy and may contribute to the development of retinopathy.
- Trial name
- NCT00406991
- Testing
- aspirin, clopidogrel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Schepens Eye Research Institute
Hepatocellular Carcinoma, Recurrence
Clinical Study of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery
Evaluation the Treatment Outcome of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery.
- Trial name
- NCT01936233
- Testing
- Aspirin, Lamivudine
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Fudan University
Gastric Ulcers, Duodenal Ulcers
Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin
The purpose of this study is to evaluate the safety of TAK-438, once daily (QD), during long-term concomitant low-dose aspirin therapy in patients with a history of gastric or duodenal ulcer who require long-term therapy of…
- Trial name
- NCT01456247
- Testing
- TAK-438, Lansoprazole
- Where
- 76 sites in Japan
- Volunteers
- 439 people
- Sponsor
- Takeda
Impaired Glucose Tolerance, Prediabetic State
Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance
The purpose of this study is to determine whether cardiovascular disease (CVD) risk markers, β-cell function, and insulin sensitivity can be improved by targeting mechanisms of both diabetes and CVD - using an antioxidant, an…
- Trial name
- NCT00122447
- Testing
- Aspirin, Alpha lipoic acid, Olmesartan
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Preeclampsia, Pregnancy Loss
Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.
Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization to evaluate the pharmacological effect in terms of placentation, gene expression, protein synthesis…
- Conditions
- Preeclampsia, Pregnancy Loss, Preterm Birth, Healthy
- Trial name
- PLORG (NCT06893978)
- Testing
- Placenta organoids treatment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prostate Cancer
A Study to Examine the Effectiveness of Aspirin and/or Vitamin D3 to Prevent Prostate Cancer Progression
To demonstrate the acceptability and feasibility of recruitment to a randomised chemoprevention study of standard (300mg) or low dose (100mg) aspirin vs. placebo and/or Vitamin D3 vs.
- Trial name
- PROVENT (NCT03103152)
- Testing
- High dose Aspirin & Vitamin D, Low dose Aspirin , Vitamin D
- Where
- 7 sites in United Kingdom
- Volunteers
- 104 people
- Sponsor
- Queen Mary University of London
Fentanyl, Platelet Reactivity
Platelet Reactivity With Fentanyl, Morphine, or no Narcotic
The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort.
- Trial name
- NCT05367336
- Testing
- Morphine, Fentanyl
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
Atherosclerosis of the Peripheral Artery
Pilot Prospective Study of Two Methods of Revascularization of the Femoral Artery (SFA): Stenting in the SFA, and Stenting of the SFA, Supplemented by Fasciotomy in Hunter Channel.
Comparison of two methods for revascularization of the superficial femoral artery: stenting of the superficial femoral artery vs.
- Trial name
- NCT02590471
- Testing
- Angioplasty with stenting of the femoral artery, Angioplasty with stenting of the femoral artery, supplemented by fasciotomy in Hunter's channel
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Ischemic Stroke
Prevalence of Aspirin Resistance in Ischemic Stroke Patients at Assiut University Hospital
This study aims to assess the prevalence of aspirin resistance in patients with acute ischemic stroke and its importance in secondary stroke prevention.
- Trial name
- NCT05151263
- Testing
- Acetyl Salicylate, Optical Platelet Aggregation test
- Where
- Egypt
- Volunteers
- 133 people
- Sponsor
- Assiut University
Carotid Artery Occlusion, Middle Cerebral Artery Occlusion
The Carotid and Middle Cerebral Artery Occlusion Surgery Study
The recently published Carotid Occlusion Surgery Study (COSS) failed to show a benefit of extracranial-intracranial (EC-IC) bypass surgery over medical therapy in patients with symptomatic hemodynamically significant carotid…
- Conditions
- Carotid Artery Occlusion, Middle Cerebral Artery Occlusion, Stroke
- Trial name
- CMOSS (NCT01758614)
- Testing
- bypass surgery, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Xuanwu Hospital, Beijing
Oral Antiplatele, Anticoagulant Drugs
Effect of Oral Antiplatelet or Anticoagulant Drugs on Postoperative Bleeding Risk and Venous Closure Rate in Patients With Lower Extremity Varicose Veins After Radiofrequency Ablation
This observational study aims to assess the effect of oral antiplatelet or anticoagulant drugs on key postoperative outcomes in patients with lower extremity varicose veins who have undergone radiofrequency ablation.
- Conditions
- Oral Antiplatele, Anticoagulant Drugs, Lower Extremity Varicose Veins, Radiofrequency Ablation
- Trial name
- NCT07208695
- Testing
- Antiplatelet or Anticoagulant Drugs
- Volunteers
- 40 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
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