Clinical trials: Amoxicillin, open to volunteers
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Combination Study of Antibiotics With Enzalutamide (PROMIZE)
PROMIZE is an open-label, multi-centre, single-arm, Phase I/II clinical trial, evaluating the safety, tolerability and anti-tumuor efficacy of an antibiotic combination and enzalutamide in patients with metastatic…
- Trial name
- NCT06126731
- Testing
- Enzalutamide 40mg, Amoxicillin 500mg, Metronidazole 400mg
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Institute of Cancer Research, United Kingdom
HELICOBACTER PYLORI INFECTIONS
Tegoprazan Plus Amoxicillin BID vs TID Regimens for H. Pylori Eradication（Frequency Adjusted Same-dose Therapy for H. Pylori）
This study is designed to evaluate two different tegoprazan-based dual therapy regimens for the treatment of Helicobacter pylori (H. pylori) infection.
- Trial name
- FAST-HP (NCT07242443)
- Testing
- Tegoprazan 50 mg, Amoxicillin 1 g TID, Amoxicillin 1.5 g BID
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First People's Hospital of Hangzhou
Helicobacter Pylori Infection
Head-to-head Study of Tegoprazan 50 mg BID Plus Amoxicillin 1 g TID vs. Vonoprazan 20 mg BID Plus Amoxicillin 1 g TID for H. Pylori Eradication
This study is a randomized, open-label, parallel-group clinical trial designed to compare two 14-day dual therapies for the eradication of Helicobacter pylori (H. pylori) infection.
- Trial name
- TV-HP (NCT07242456)
- Testing
- Tegoprazan, Amoxicillin, Vonoprazan
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First People's Hospital of Hangzhou
Cat Bite, Hand Injuries
CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)
Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries.
- Conditions
- Cat Bite, Hand Injuries, Arm Injury, Infection, Bacterial
- Trial name
- CATBITE (NCT05846399)
- Testing
- Amoxicillin/clavulanate, Ciprofloxacin, Clindamycin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Malnutrition, Child, Severe Acute Malnutrition
Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition
Amoxicillin is recommended by the World Health Organization (WHO) as adjunctive therapy for the treatment of uncomplicated severe acute malnutrition (SAM).
- Trial name
- AMOUR (NCT06010719)
- Testing
- Azithromycin, Amoxicillin
- Where
- Burkina Faso
- Volunteers
- 3,000 people
- Sponsor
- University of California, San Francisco
Myeloma, Non-Hodgkin's Lymphoma
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)
This is an adaptive platform study to find out how safe and effective different strategies are in comparison to each other, for preventing infection in patients with blood cancers.
- Conditions
- Myeloma, Non-Hodgkin's Lymphoma, Leukemia
- Trial name
- NCT07202052
- Testing
- Intravenous immunoglobulin, Trimethoprim / Sulfamethoxazole, Amoxicillin clavulanic acid
- Where
- 3 sites in Australia
- Volunteers
- 900 people
- Sponsor
- Monash University
Myeloma, Leukemia
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig)
This study is being conducted to find out how safe and effective different strategies of infection prevention are in comparison to each other, for preventing infection in patients with blood cancers.
- Conditions
- Myeloma, Leukemia, Non Hodgkin's Lymphoma
- Trial name
- NCT07202091
- Testing
- Trimethoprim Sulfamethoxazole, Amoxycillin/clavulanic acid, Immune Globulin Intravenous
- Where
- 3 sites in Australia
- Volunteers
- 900 people
- Sponsor
- Monash University
Acute Coronary Syndrome, Helicobacter Pylori Infection
The Effect of Dual Eradication Therapy vs PPI on Gastrointestinal Bleeding in ACS Patients
Patients with acute coronary syndrome (ACS) after Percutaneous Coronary Intervention (PCI) require routine treatment with dual antiplatelet (DAPT) treatment, but with the high risk of bleeding, gastrointestinal bleeding is the…
- Trial name
- NCT04728516
- Testing
- Vonoprazan-based dual eradication therapy for two weeks, amoxicillin, Pantoprazole
- Where
- 42 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Qilu Hospital of Shandong University
Helicobacter Pylori Infection, Metabolic-associated Steatohepatitis
Huazhi Rougan Granule as an Add-On Therapy for H. Pylori Infection With Metabolic-associated Steatohepatitis
This study employed a double-blind, randomized, placebo-controlled design. Eligible treatment-naïve patients with Helicobacter pylori (Hp) infection complicated by metabolic-associated steatohepatitis (MASH) (dampness-heat…
- Conditions
- Helicobacter Pylori Infection, Metabolic-associated Steatohepatitis, High-dose Dual Therapy, Huazhi Rougan Granule
- Trial name
- NCT07159412
- Testing
- Vonoprazan-amoxicillin combined with Huazhi Rougan Granule
- Volunteers
- 286 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Erythema Migrans of Lyme Disease
Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))
The aim of this study is to assess the effect of Saccharomyces boulardii CNCM I-745 on gut microbiota in patients undergoing antibiotic therapy (in the context of erythema migrans (early skin form of Lyme borreliosis)).
- Trial name
- SUBLYME (NCT06451913)
- Testing
- Amoxicillin + Saccharomyces boulardii CNCM I-745, Stool samples, BSFS : Bristol Stool Form Scale
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- Biocodex
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment.
- Trial name
- NCT07068607
- Testing
- Vonoprazan, Tetracycline 500mg tid, Minocycline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Helicobacter Infection
Clinical Trial to Evaluate the Efficacy of Probit-Based Triple Therapy for Helicobacter Pylori Eradication
This is a single-center, open-label, non-randomized, single-arm clinical study. Eligible participants who provide written informed consent will undergo screening based on inclusion/exclusion criteria.
- Trial name
- NCT07115173
- Testing
- This study aims to evaluate the efficacy and safety of a 14-day triple therapy regimen consisting of Zastaprazan 20 mg, clarithromycin, and amoxicillin for the eradication of Helicobacter pylori.
- Volunteers
- 103 people
- Sponsor
- Samsung Medical Center
Helicobacter Pylori
Efficacy and Safety of Keverprazan-amoxicillin Dual Therapy for Helicobacter Pylori First-line Treatment
This is an open-label, randomized controlled study. The study plans to enroll 414 subjects with Helicobacter pylori infection, who will be randomly assigned to the experimental group (Keverprazan dual therapy for 10 days or…
- Trial name
- NCT07122024
- Testing
- Keverprazan 10 days, Keverprazan 14 days, Rabeprazole
- Where
- China
- Volunteers
- 414 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Erysipelas
Comparing Short to Standard Amoxicillin Course for Erysipelas
Erysipelas is an acute streptococcal skin infection, primarily affecting the lower limbs and easily diagnosed. In 2000, the French expert consensus conference validated oral amoxicillin at 3 to 4.5 gr per day for 10 to 20 days as…
- Trial name
- SHAREII (NCT07104552)
- Testing
- Course of amoxicillin
- Volunteers
- 656 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
H Pylori
Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment…
- Trial name
- NCT07040839
- Testing
- Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg
- Where
- Pakistan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Helicobacter Pylori Infection
Comparison of Two Treatment Regimens of Helicobacter Pylori Infection
The goal of this interventional study is to compare the efficacy of clarithromycin Vs levofloxacin based regimen in treatment of Helicobacter pylori infection in patients presenting to medical OPD who are tested positive for H…
- Trial name
- NCT07021729
- Testing
- Clarithromycin, Levofloxacin
- Volunteers
- 156 people
- Sponsor
- Rehman Medical Institute - RMI
Preterm Birth
PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol]
PLATIPUS is an adaptive platform trial aimed at improving the health of infants born preterm (before 37 weeks' gestation). PLATIPUS will compare how different treatments and care provided to pregnant women and people at risk of…
- Trial name
- PLATIPUS (NCT06461429)
- Testing
- Erythromycin, Amoxicillin and Erythromycin, Azithromycin
- Volunteers
- 100,000 people
- Sponsor
- University of Melbourne
Helicobacter Pylori Infection
Vonoprazan Evaluation Compared to Standard Triple Therapy in Helicobacter Pylori eRadication
Helicobacter pylori (H Pylori) infection is associated with functional dyspepsia, peptic ulcer disease, atrophy and gastric cancer. The bacterium has been classified as grade I carcinogen by the WHO in 1994(1).
- Trial name
- NCT06959368
- Testing
- Vonoprazan 20mg, Esomeprazole 40 mg, Amoxicillin 1 g, Clarithromycin 500 mg
- Where
- India
- Volunteers
- 484 people
- Sponsor
- Asian Institute of Gastroenterology, India
Community-acquired Pneumonia
Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.
The aim of this study will be to evaluate whether a twice-daily antibiotic regimen is non-inferior to a thrice-daily regimen for the treatment of non-severe community acquired pneumonia in children presenting at a paediatric…
- Trial name
- NCT03031210
- Testing
- Amoxicillin
- Where
- Canada
- Volunteers
- 1,370 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Helicobacter Pylori Infection
The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori Infection
Helicobacter pylori (H. pylori) is one of the most common chronic infections worldwide. The mode of transmission of H. pylori is through the fecal-oral or oral-oral routes.
- Trial name
- NCT06964334
- Testing
- Lansoprazole, amoxicillin, clarithromycin
- Volunteers
- 70 people
- Sponsor
- Assiut University