Clinical trials: Phase not applicable
Cognitive Decline
Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
The aim of this study is to investigate the modulation effects of Baduanjin (BDJ), a simple and innovative mind-body exercise, on cognitive function, resting state functional connectivity, and brain morphometry in individuals…
- Trial name
- BDJ (NCT04009382)
- Testing
- Baduanjin Exercise, Cognitive Fitness Program
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease
Locus-coeruleus Function in Normal Elderly and AD Risk
Growing evidence suggests that Alzheimer's disease (AD) pathological changes begin decades before clinical symptoms and tau abnormalities in the locus coeruleus (LC) can be observed since midlife.
- Trial name
- LEAD (NCT04403165)
- Testing
- Nocturnal polysomnography (NPSG), Lumbar Puncture (LP), PET-MR measurement with a norepinephrine transporter (NET)-selective radiotracer (S,S)-[11C]Omethylreboxetine ([11C]MRB)
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Overweight and Obesity
The Feasibility and Preliminary Efficacy of the Mindful-Healthy Family Intervention With Rural Families
This two-group RCT, the Mindful-Healthy Family project, will test the feasibility and preliminary efficacy of a mindfulness-based Motivational Interviewing (MM-based-MI) intervention with rural families within Michigan.
- Trial name
- MHFproject (NCT05324969)
- Testing
- MM-based MI, healthy education
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Haptonomy, Prenatal Loss
The Effect of Haptonomy Practice on Risk Perception, Distress and Attachment in Pregnant Women With Prenatal Loss
The research was conducted to determine the effects of haptonomy application given to pregnant women who experienced prenatal loss on risk perception, distress and attachment.
- Trial name
- Haptonomy (NCT07403240)
- Testing
- Haptonomy
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Inonu University
Obstruction Airway
Positive Airway Pressure (PAP) System Evaluation in Volunteers
This study will test the control and measurements of a new system for airway support in healthy volunteers. The goals of the study are to evaluate how accurately the system can stabilize airway pressure to a desired level…
- Trial name
- NCT07246538
- Testing
- CPAP
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Utah
Autism Spectrum Disorder, Patient Engagement
Testing Design Thinking Methodology to Engage Hispanic and Latino Families of Autistic Children in Research.
The goal of this study is to compare two methods of engagement in research that include autistic individuals, Hispanic and Latino parents of autistic children, occupational therapy clinicians, teachers, and to use the information…
- Trial name
- NCT06111092
- Testing
- Design Thinking, Focus Groups
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Accidental Falls
Home Hazard Removal Program to Reduce Falls
This study evaluates the effectiveness and implementation of a home-hazard removal program to reduce falls in older adults through a community program delivered through the aging services network.
- Trial name
- HARP (NCT02392013)
- Testing
- Home Modification
- Where
- United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07215299
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Apical Periodontitis, Pulp Disease, Dental
In-Vivo Diagnostic Accuracy and Repeatability of Root ZX3 for Working-Length Determination in Single-Rooted Teeth: Agreement With CBCT and Microscopic Validation
This study evaluated the accuracy and repeatability of the Root ZX3 electronic apex locator for working-length determination in 77 single-rooted permanent teeth.
- Conditions
- Apical Periodontitis, Pulp Disease, Dental, Device Reliability, Device Performance
- Trial name
- NCT07689838
- Testing
- Root ZX3 Electronic Apex Locator
- Where
- Saudi Arabia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Accidental Fall
Adapted Lifestyle-integrated Functional Exercise Program for Medically Underserved Older Adults
This study will test the feasibility of a study design for the Adapted Lifestyle-integrated Functional Exercise (LiFE) program for medically underserved older adults and to explore factors related to implementation.
- Trial name
- LiFE (NCT03704194)
- Testing
- Adapted LiFE, Attention control
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dementia Alzheimers, Alzheimer Disease
Person-Environment Fit for Persons With Dementia
This trial will assess feasibility of a non-pharmacological intervention for persons living with Alzheimer's disease and related dementias (ADRD) to improve behavioral and psychiatric symptoms of dementia and functional…
- Trial name
- NCT05722743
- Testing
- Harmony, National Institute on Aging Program
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Elizabeth K Rhodus
Depression, Anxiety
Low Intensity Family Support for Refugees in an LMIC
The rapidly growing scale of humanitarian crises requires new response capabilities geared towards addressing populations with prolonged high vulnerability to mental health consequences and little to no access to mental health…
- Conditions
- Depression, Anxiety, PTSD, Family Dynamics
- Trial name
- NCT03978533
- Testing
- Family Support Group
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Hiatal Hernia
Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia
This is a prospective randomized, double-blinded, controlled trial that will target enrollment of 46 subjects undergoing laparoscopic hiatal hernia repair surgery.
- Trial name
- NCT05953428
- Testing
- Opioid Sparing Anesthesia Protocol (OSA), Opioid Based Anesthesia Protocol (OBA)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Astigmatism
Evaluation of Delefilcon A and Senofilcon A Daily Disposable Toric Soft Contact Lenses Over One Week of Wear
This is a prospective, multi-site, 4-visit, bilateral, dispensing, randomized, controlled, double-masked, 2x2 crossover study to evaluate subjective comfort, overall opinion and end of day comfort following wear of two different…
- Trial name
- NCT06749496
- Testing
- Test Lens, Control Lens
- Where
- 12 sites in United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Astigmatism
Evaluation of Daily Disposable Toric Soft Lenses Manufactured With an Alternative Hydration Process
This is a prospective, multi-site, dispensing, randomized, controlled, double-masked, bilateral wear, 2x2 crossover study to evaluate the safety and effectiveness of the test lens.
- Trial name
- NCT06967129
- Testing
- Investigational daily disposable, soft, toric lenses manufactured on 4th Generation Technology (4GT) lines with extended mini-stack hydration using propylene glycol (PG) as the hydration solvent., ACUVUE® Oasys 1-Day for Astigmatism (AO1DfA) soft contact lenses manufactured on 3rd Generation Technology (3GT) legacy lines using isopropyl alcohol (IPA) as the hydration solvent.
- Where
- 20 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Human Immunodeficiency Virus, Human Immunodeficiency Virus Transmission
The OPENS Trial: Offering Women PrEP (Aim 2)
To address the significant barriers to pre-exposure prophylaxis (PrEP) implementation for cisgender women and address racial inequities in HIV prevention in the United States (US), a novel approach that accounts for multilevel…
- Conditions
- Human Immunodeficiency Virus, Human Immunodeficiency Virus Transmission, Sexually Transmitted Diseases
- Trial name
- NCT05619497
- Testing
- Clinic-wide Trainings, Clinic-wide Trainings and HIV Prevention Decision Support Tool (DST)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxemia Conditions
The major aim is to evaluate accuracy of 2 Continuous Glucose Monitoring Systems (CGMS) : Dexcom G6® and FreeStyle Libre® in standardized hypoxemia conditions (artificial normobaric hypoxia).
- Trial name
- NCT05144802
- Testing
- acute hypoxia
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Anterior Cruciate Ligament Tear, Knee Injuries
Use of Blood Flow Restriction Therapy Following ACL Tear
Evaluating the use of peri-operative blood flow restriction therapy surrounding anterior cruciate ligament tear
- Conditions
- Anterior Cruciate Ligament Tear, Knee Injuries, Sport Injury
- Trial name
- NCT04374968
- Testing
- Blood flood restriction cuff
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
COVID-19, COVID
Clinical Validation of the Aptitude Medical Systems Metrix COVID-19 Test
The Metrix COVID Test will be evaluated for use in Point-of-Care and Non-Laboratory settings in a home testing environment utilizing the clinical study design described herein.
- Trial name
- NCT06744660
- Testing
- Aptitude Medical Systems Metrix COVID Test
- Where
- United States
- Volunteers
- 697 people, healthy volunteers welcome
- Sponsor
- Aptitude Medical Systems
Carpal Tunnel
Clinical Outcomes of USCTR vs. mOCTR
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy and affects 3-6% of adults in the United States.
- Trial name
- NCT04504019
- Testing
- USCTR, mOCTR
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
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