Clinical trials: sponsored by Karolinska Institutet
Obesity, Childhood
MINISTOP Plus Program for Pre-school Children With Overweight and Obesity
The Mobile-based intervention intended to stop obesity in preschoolers (MINISTOP) program has been developed to be a comprehensive digital support program for all children irrespective of weight status.
- Trial name
- NCT05529043
- Testing
- MINISTOP app, MINISTOP Plus Program
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Physical Inactivity, Environmental Exposure
Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes
By reconstructing schoolyards with greenery, physical activity levels among children can be increased at the population level and also mitigate health and environmental risks resulting from rising climate changes in urban areas.
- Conditions
- Physical Inactivity, Environmental Exposure, Mental Health Wellness 1
- Trial name
- NCT05865782
- Testing
- Schoolyard reconstruction
- Where
- Sweden
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Influenza A Infection, Influenza B Virus Infection
Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection
The goal of this observational study is to understand immune responses to viral airway infection in adults, including the elderly.
- Conditions
- Influenza A Infection, Influenza B Virus Infection, SARS CoV 2 Infection, RSV Infection
- Trial name
- NPA-DC (NCT06401720)
- Where
- 5 sites in Sweden
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Midwifery
MIDWIZE - Strengthening Midwives
This PhD project aims to explore how midwives can take the lead in implementing and enhancing evidence-based quality improvement (QI) components within maternal and newborn health care in Uganda.
- Trial name
- NCT05237375
- Testing
- The MIDWIZE model
- Where
- 4 sites in Uganda
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Mental Health Wellness 1
Evaluating the Hope@School Prevention Program
This multi-center cluster-randomized controlled trial aims to evaluate the feasibility, effectiveness and overall impact of the Hope@School (H@S) program by comparing mental health outcomes in students participating in the H@S…
- Trial name
- Hope@School (NCT06359262)
- Testing
- Hope@School, Treatment as usual
- Volunteers
- 3,220 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Osteoporosis, Osteopenia
Effects of OsteoStrong vs. Individually Adapted and Combined Training on Bone Health
The aim of this clinical trial is to investigate the effect of the OsteoStrong training method and the Individually Adapted and Combined Training on the bone health of older women with high fracture risk.
- Conditions
- Osteoporosis, Osteopenia, Bone Density, Low, Bone Loss
- Trial name
- NCT05721014
- Testing
- OsteoStrong, Individually Adapted and Combined Physical Training
- Where
- Sweden
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Self Efficacy
Saga Stories in Health Talks in Primary Child Healthcare
Primary child healthcare in Sweden is an important arena for health promotion interventions as nurses regularly meet parents and children from birth to five years of age.
- Trial name
- NCT05237362
- Testing
- Saga Stories
- Where
- Sweden
- Volunteers
- 763 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Perfectionism, Anxiety
Treating Perfectionism Using Internet-Based Cognitive Behavior Therapy
Perfectionism is characterized by setting high standards and striving for achievement, sometimes at the expense of social relationships and wellbeing.
- Conditions
- Perfectionism, Anxiety, Depression, Stress
- Trial name
- NCT04459260
- Testing
- Cognitive Behavior Therapy, Unified Protocol
- Where
- Sweden
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Rhinitis, Allergic, Seasonal, Hay Fever
Methylprednisolone Injections Treating Birch Pollen Induced Allergic Rhinitis.
This study evaluates the effect of intramuscular injected methylprednisolone treating birch pollen induced rhinitis compared to placebo.
- Conditions
- Rhinitis, Allergic, Seasonal, Hay Fever, Pollen Allergy, Allergic Rhinitis
- Trial name
- NCT04622917
- Testing
- MethylPREDNISolone 40 Mg/mL Injectable Suspension, NaCl 9 MG/ML Injectable Solution
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Family Violence, Domestic Violence
How Can Child Health Services Identify and Respond to Family Violence
Family violence has severe impacts on children's health and development. The Child Health Services (CHS) in Sweden reaches almost 100% of families with young children and provides a unique setting to facilitate identification of…
- Conditions
- Family Violence, Domestic Violence, Intimate-partner Violence
- Trial name
- NCT06299501
- Testing
- Routine questions, Questions on evidence based indication, Treatment as usual
- Where
- Sweden
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Lung Inflammation
The Effects of Heated Tobacco Products Use on Lung Function and Volatile Organic Compounds in Exhaled Air
This is a human randomized controlled cross-over study where we investigate the effects of heated tobacco products (HTP) on lung function and on assessing volatile organic compounds in exhaled air.
- Trial name
- NCT05260827
- Testing
- Heated tobacco product
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Atrial Fibrillation, Atrial Flutter
Excessive Supraventricular Activity and Atrial Fibrillation
The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Supraventricular Beat, Premature, Premature Supraventricular Beats
- Trial name
- ESA-AF (NCT04593498)
- Testing
- Holter recording, Echocardiography (Echo), Blood sample
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Breast Cancer
Stockholm Mammography Risk Stratified Trial
SMART is a Phase III, randomised, non-blinded screening trial. Women who consent to participate in SMART are randomised to either individualised screening or screening according to the Swedish National Breast Cancer Screening…
- Trial name
- SMART (NCT06270355)
- Testing
- Risk based screening
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Immunodeficiency, Autoimmune Diseases
SYSTEMS-LEVEL ANALYSES OF IMMUNE DYSREGULATION
The aim of the SAID study is to create a national resource in Sweden to enable comprehensive immunological analyses of an extremely complex and clinically challenging group of individuals with variable forms of immune system…
- Conditions
- Immunodeficiency, Autoimmune Diseases, Autoinflammatory Syndrome, Allergy
- Trial name
- SAID (NCT06248957)
- Testing
- Immunomodulation
- Where
- Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Problem Gambling
Internet Based Self-help for Problem Gambling Concerned Significant Others
The project aims to evaluate a brief online self-help intervention for Concerned Significant Others of individuals with Problem Gambling.
- Trial name
- NCT06230809
- Testing
- Web-based self-help
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Work Related Stress
mHealth Intervention for Work-Related Stress
The objective of the trial is to pilot test the study protocol of a preventive, low-intensive mobile health (mHealth) intervention for work-related stress among nursing students.
- Trial name
- DIARY (NCT06228495)
- Testing
- Daily Intervention for Active Recovery
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Neurodevelopmental Disorders, Autism
Early Life Anemia and Children's Risk of Neurodevelopmental Disorders: National and Regional Register-based Studies
The overall project aim is to study children's neurodevelopmental outcomes (including diagnoses of autism, ADHD, and intellectual disability) following exposure to maternal anemia during pregnancy or anemia during the first year…
- Conditions
- Neurodevelopmental Disorders, Autism, ADHD, Intellectual Disability
- Trial name
- NCT06199362
- Where
- Sweden
- Volunteers
- 2,400,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Prostate Cancer
Prostate Cancer Detection Using the Stockholm3 Test and MR/Fusion Biopsies
The STHLM3-MRI trial is a study comparing traditional prostate cancer detection using PSA and systematic biopsies with the improved pipeline for prostate cancer detection using the STHLM3 test and targeted biopsies in a screening…
- Trial name
- STHLM3MR-2 (NCT03377881)
- Testing
- MRI/Fusion biopsies, Systematic biopsies
- Where
- 3 sites in Sweden
- Volunteers
- 12,750 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Functional Movement Disorders, Reproducibility of Results
Aspects of Validity of the Single Leg Squat Test: A Cohort Study of Female Soccer Players.
Movement screening tests to identify deficits or poor movement quality is commonly used in soccer and other sports to assess injury, to evaluate rehabilitation goals and return to sport after injury.
- Conditions
- Functional Movement Disorders, Reproducibility of Results, Sports Medicine
- Trial name
- NCT05289284
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Latent Autoimmune Diabetes in Adults, Type 2 Diabetes
Infections and Latent Autoimmune Diabetes in Adults
Infections are proposed risk factors for type 1 diabetes in children. The investigators will examine whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults.
- Trial name
- LADA (NCT06167616)
- Where
- Sweden
- Volunteers
- 5,048 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet