Clinical trials: sponsored by Karolinska Institutet
Body Dissatisfaction, Eating Disorders
Prevention of Eating Disorders Through Optimization of Protective Factors
The goal of thin randomized controlled trial is to investigate the efficacy of a prevention program for reducing the incidence of eating disorders among youth (15-20).
- Trial name
- NCT05863598
- Testing
- Enhancing protective factors, Expressive writing
- Where
- Sweden
- Volunteers
- 644 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dementia, Dementia Alzheimers
Acrylamide and Health Outcomes
Acrylamide, a widespread food-processing contaminant, poses a major public health concern due to its high exposure level in the general population and its toxicity.
- Conditions
- Dementia, Dementia Alzheimers, Parkinson Disease, Myocardial Infarction
- Trial name
- NCT06224725
- Testing
- dietary acrylamide exposure measured via biomarkers in blood (hemoglobin adducts of acrylamide and glycidamide)
- Where
- Sweden
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 2, Circadian Rhythm
Circadian Rhythm and Metabolic Effects of Exercise
Physical exercise is efficacious in controlling blood glucose levels in individuals with Type 2 diabetes. An individual's exercise capacity and ability to utilize glucose as an energy source oscillates throughout the day.
- Conditions
- Diabetes Mellitus, Type 2, Circadian Rhythm, Glycemic Control
- Trial name
- HITMet (NCT05115682)
- Testing
- High-intensity Intermittent Exercise
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
DENV Without Warning Signs, DENV with Warning Signs
Innovative Multidisciplinary Strategies for Combating Severe Dengue
The goal of this observational study is to identify biomarkers and host factors associated with dengue severity in patients from dengue-endemic regions.
- Conditions
- DENV Without Warning Signs, DENV with Warning Signs, Severe Dengue, Healthy Controls Group - Age and Sex-matched
- Trial name
- COMBAT (NCT06751836)
- Testing
- Infection and no infection
- Where
- 2 sites in Guatemala, India
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Breast Cancer, Mammographic Density
Karolinska Interventional Study of Mammograhic Density (Karisma-1)
A feasibility study, randomising to either 10 or 20 mg of tamoxifen. The primary aim is to identify the time to mammographic density change and piloting the procedures.
- Trial name
- Karisma-1 (NCT04079517)
- Testing
- Tamoxifen
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diastasis Recti
Naprapathy Training for Postpartum DRAM Prevention
A randomised controlled trial with the aim of analysing the effectiveness of a training program intended to prevent symptoms related to DRAM in the postpartum period.
- Trial name
- NapraDRAM (NCT04652830)
- Testing
- Naprapathy training, Control group
- Where
- Sweden
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Alzheimer´s Disease
Molecular PET Imaging and Plasma Biomarkers in Alzheimer´s Disease and Other Neurodegenerative Diseases
Multi-modal PET tracer study with the aim of studying the time course of regional deposition of tau in brain of subjects with high risk of being carriers of autosomal dominant Alzheimer´s disease and sporadic early onset and late…
- Trial name
- ROADAD (NCT06731842)
- Testing
- 18F-RO948
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Psychiatric Problem, Psychiatric Issue
Virtual Patients - An Interactive Educational Module for Higher Education
Popular Science Summary (for the whole project) In modern healthcare, several challenges exist: short patient visits, highly specialized care, and limited opportunities for education and professional development among healthcare…
- Conditions
- Psychiatric Problem, Psychiatric Issue, Violence
- Trial name
- NCT06706011
- Testing
- Virtual Patient
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Recovery, Psychological, Sleep
Leadership for Recovery: Evaluation of an Intervention Programme for First-line Healthcare Managers
The goal of this intervention study is to evaluate a group intervention programme that aims to support first-line healthcare managers in promoting their employees' recovery through a "leadership for recovery".
- Conditions
- Recovery, Psychological, Sleep, Burnout, Work Related Stress
- Trial name
- NCT06678347
- Testing
- Leadership for recovery
- Where
- 2 sites in Sweden
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Contraceptive Usage, Telemedicine
Telemedicine Contraceptive Counselling (TECC) Versus Standard Care
Overall purpose of the PILOT and RCT: This research project aims to increase access and uptake of contraception after abortion through the systematic development and testing of a new telemedicine service for contraceptive…
- Trial name
- TECC (NCT06682065)
- Testing
- Telemedicine for contraceptive counseling (TECC), Standard Care
- Where
- 2 sites in South Africa
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cardiovascular Diseases, Lung Diseases
Swedish CArdioPulmonary bioImage Study 2
In the Swedish CArdioPulmonary bioImage Study (SCAPIS 1), 30,154 randomly selected men and women, aged 50-64 years, were recruited from six areas in Sweden during 2013-2018.
- Trial name
- SCAPIS2 (NCT06679777)
- Where
- 6 sites in Sweden
- Volunteers
- 30,154 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Parkinson Disease, Gait Disorders, Neurologic
Walking and Thinking - Brain Activity During Complex Walking in Aging and Parkinson's Disease
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Parkinson Disease, Gait Disorders, Neurologic, Aging
- Trial name
- ParkMOVE (NCT05218213)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Type 1 Diabetes, Overweight
Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in…
- Trial name
- NCT05277532
- Testing
- High intensity interval training (HIIT)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Polycystic Ovary Syndrome, Insulin Resistance
Acupuncture or Metformin for Insulin Resistance in Women With PCOS
The hypothesis is that acupuncture is equally effective as metformin (both treatments combined with lifestyle management) in improving whole body glucose homeostasis in insulin resistant women with polycystic ovary syndrome…
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
- Trial name
- PIAII (NCT02647827)
- Testing
- Lifestyle management, Acupuncture, Metformin
- Where
- 2 sites in China, Sweden
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity, Overweight
Overweight and Obesity in Preschoolers
Obesity interventions in early childhood are recommended as they have been proven to be more effective than interventions later in life.
- Trial name
- MLEurope (NCT03800823)
- Testing
- Parent group, mHealth component, Standard care
- Where
- 3 sites in Romania, Spain and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
PPH
Postpartum Hemorrhage Reduction With Oral Tranexamic Acid: a Clinical Trial
This is a multicentre randomized placebo-controlled double-blinded phase IV study among 1000 women in Sweden and South Africa on the effect of oral tranexamic acid on PPH after vaginal delivery.
- Trial name
- PROTECT (NCT06025916)
- Testing
- Tranexamic acid
- Where
- Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Autoantibodies
Follow-up Study of Individuals with Autoantibodies Against Ro/SSA and La/SSB
In this study, individuals with autoantibodies against Ro/SSA and La/SSB will be followed with regard to clinical manifestations and immunological parameters to identify immunological changes, environmental factors, and early…
- Trial name
- ProgreSS (NCT06594861)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Prostate Cancer
Stockholm3 Use Prior to MRI for Prostate Cancer Detection in a Clinical Care Pathway: a Multi-centered Validation
Men meeting local clinical standard of care to undergo a prostate MRI for suspicion of prostate cancer will be included. Blood sample will be drawn on the day of MRI or immediately prior to MRI for measurement of the prostate…
- Trial name
- S3M-MRI (NCT06573736)
- Testing
- Stockholm3
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
COVID-19, Childhood Cancer
COVID-19 and Childhood Cancer
The investigators will first examine the impact of the COVID-19 pandemic on childhood cancer patients in Sweden and Denmark, both regarding susceptibility to severe COVID-19 among long-term childhood cancer survivors, and, for…
- Conditions
- COVID-19, Childhood Cancer, Childhood Leukemia, Acute Lymphoblastic
- Trial name
- NCT06482281
- Where
- Sweden
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Exercise Induced CD8+ T Cell Recruitment and Characterization of Function and Phenotype of These Cells
Functional Characterization of CD8+ T Cells After Supramaximal Exercise
Healthy human subjects perform supramaximal exercise with venous blood samples obtained before and up to 60 minutes after the exercise bout.
- Trial name
- NCT06484101
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet