Clinical trials: sponsored by Karolinska Institutet
Insulin Sensitivity
Insulin Sensitivity and Beta Cell Function After Carbohydrate Loading in Hip Replacement Surgery
The purpose of this study is to determine whether preload of carbohydrate or water before elective hip replacement improve insulin sensitivity and or beta cell function in human.
- Trial name
- NCT01774084
- Testing
- Experimental: PreOp, NutriciaNordica AB
- Where
- 2 sites in Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Resting Metabolic Rate
Modulation of Metabolic Rate by Inorganic Nitrate
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
- Trial name
- NCT02022176
- Testing
- Glucose Uptake, Resting metabolic rate, Nitrite infusion
- Where
- Sweden
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity, Anaesthesia
CPAP/PSV Preoxygenation in Obese Patients
The purpose of this study is to determine whether continuouse positive airway pressure (CPAP), during induction of anaesthesia in morbidly obese patients, result in higher levels of oxygen in the blood.
- Trial name
- NCT01780571
- Testing
- CPAP 5 cm H2O + PSV 5 cm H2O
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dental Caries
Optimised Fluoride Prevention by Double Rinse With Fluoride and Calcium
Aim: to determine the optimal Ca2+ concentration with 905 ppm F as NaF. Study design: Experimental study in 10 volunteers. Single blind mouth rinse with calcium lactate solution (150; 75; 0 mM Ca-lactate) is immediately followed…
- Trial name
- Fluor-Ca (NCT01473537)
- Testing
- calcium lactate solution
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Problem Behaviors Among Students, Classroom Learning Environment
Effects of Prevention in School (PS): a Swedish School-wide Positive Behavior Support Program at the Primary Prevention Level
Prevention in School (PS) is a modified School-Wide Positive Behavior Support Program at the universal prevention level, developed by Swedish researchers for the school years 4 -9.
- Trial name
- NCT01670591
- Testing
- PS - Prevention in School
- Where
- Sweden
- Volunteers
- 3,207 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy
A PET Study to Determine Alterations in Serotonin Levels in Human Brain After a Single Dose of Escitalopram
Healthy males were examined with positron emission tomography (PET) and the radioligand 11C-AZ10419369, before and after administration of a single dose escitalopram.
- Trial name
- NCT01638689
- Testing
- Escitalopram
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Myositis
Physical Exercise as a Targeted Therapy in Patients With Chronic Rheumatic Muscle Inflammation
The objectives of this study are to test if hypoxia in muscle tissue is an important factor contributing to clinical symptoms in chronic rheumatic muscle inflammation and to evaluate if a 12 week endurance exercise program will…
- Trial name
- NCT01184625
- Testing
- Physical Exercise
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Youth Drinking
Effects of the Örebro Prevention Program on Youth Drinking
The Örebro prevention program is a brief (6 x 30 minutes)program administered to parents of 13-16 year old youths in regular parental meetings.
- Trial name
- NCT01213108
- Testing
- Örebro prevention program, Business as usual
- Where
- Sweden
- Volunteers
- 1,752 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Alcohol Abuse
Effects of Motivational Interviewing in Prison
Motivational Interviewing (MI) is a communication style demonstrated to decrease drug and alcohol use. A five session MI intervention (BSF) was implemented in the Swedish correctional system.
- Trial name
- NCT01184612
- Testing
- Motivational Interviewing; MI
- Where
- Sweden
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Type 2 Diabetes, Impaired Glucose Tolerance
Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons
A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity.
- Trial name
- SMIDIG (NCT00852982)
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hormone Replacement Therapy
Effects of Estradiol on Menopausal Breast
The purpose of this study is to evaluate the effects on breast in postmenopausal women randomized to either oestradiol in combination with DRSP or E2 in combination with NETA during six months.
- Trial name
- BrAVA (NCT00785317)
- Testing
- Angemin vs Activelle
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Decision Making, Computer-Assisted
Study of the Impact of Virtual Patient Designs on the Reasoning Pattern and Therapeutic Decision Making
There is a lack of evidence of the impact of the information provided in the introduction screen on the students diagnostic and therapeutic decisions.
- Trial name
- VPtdl-rct1 (NCT00474474)
- Testing
- Virtual patient is NOT introduced
- Where
- Sweden
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet