Clinical trials: open to volunteers, sponsored by Icahn School of Medicine at Mount Sinai
- Lead sponsor (exact) Icahn School of Medicine at Mount Sinai
- Status Open to volunteers
- Accepts healthy volunteers yes
Abnormal Uterine Bleeding, Analgesia
Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy
A randomized double-blind placebo controlled trial comparing the effect of a combined ketorolac and lidocaine paracervical block with a standard lidocaine paracervical block on procedure related pain with office hysteroscopies.
- Conditions
- Abnormal Uterine Bleeding, Analgesia, Paracervical Block
- Trial name
- NCT06653400
- Testing
- paracervical block, Lidocaine, ketorolac
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Parkinson Disease (PD), Type 1 Gaucher Disease
Parkinson's Disease in Type 1 Gaucher Disease
Parkinson's disease (PD) is an age-related movement disorder with a complex pathophysiology. Among the risk factors for PD, variants in beta-glucocerebrosidase (encoded by the gene GBA1) represent one of the most significant…
- Trial name
- NCT07886879
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Colorectal Neoplasms, Breast Neoplasms
Increasing Breast and Colorectal Cancer Screening in the Community
The goal of the proposed study is to conduct a pilot randomized controlled trial (RCT) of Chi gung, a community-based intervention using peer education and tailored navigation to simultaneously improve colorectal (CRC) and breast…
- Trial name
- NCT07748377
- Testing
- Chi gung: Stay Well, Live Well
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gut Microbiomes
Grape Impact on Human Gut Microbiome
This is a bio-specimen analysis and dietary intervention study that will examine whether the daily consumption of California table grape powder significantly modulates the gut microbiome and systemic immune profiles in healthy…
- Trial name
- NCT07797803
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Epilepsy
SeizEAR Safety Study
Determine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG).
- Trial name
- NCT07088835
- Testing
- SeizEAR
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Early Life Adversity, Trauma
Study of Cannabidiol and Neuroimaging on Stress
Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies.
- Conditions
- Early Life Adversity, Trauma, Stress
- Trial name
- SCANS (NCT07278505)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Colorectal Cancer Screening
Evaluating the Efficacy of the eNav Toolkit to Improve Colorectal Cancer Screening
The purpose of this research study is to evaluate the efficacy of a digital navigation tool, called the eNav to improve colorectal cancer screening uptake among patients treated at federally qualified health centers (FQHC)s.
- Trial name
- NCT06184594
- Testing
- eNav, Standard of Care
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gestational Diabetes Mellitus (GDM)
Validating CGM for GDM
This is a prospective pilot study to assess the validity of using a continuous glucose monitor (CGM) in diagnosing gestational diabetes mellitus (GDM).
- Trial name
- VALID (NCT06858787)
- Testing
- Continuous glucose monitor
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Traumatic Brain Injury, Emotion Regulation
Community-based Implementation of Online EmReg
This is a hybrid type III implementation-effectiveness trial; this study design blends elements of implementation and clinical effectiveness research, with the primary aim of determining the utility of an implementation strategy…
- Trial name
- NCT05933629
- Testing
- Online EmReg, Consultation Sessions
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcohol Drinking
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
The purpose of this study is to investigate the behavioral and neural correlates of stress exposure. Results from this study will enrich the understanding of how sociocultural, behavioral, and neural factors combine to influence…
- Trial name
- NCT05675332
- Testing
- Task-based behavioral intervention
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
Defining the Basis of Fibromuscular Dysplasia (FMD)
The purpose of this study has evolved and expanded since its inception. Originally the intent was to establish the functional, molecular and genetic profile of fibroblasts from Fibromuscular Dysplasia (FMD) patients as compared…
- Conditions
- Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection, Cervical Artery Dissection
- Trial name
- DEFINE (NCT01967511)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Multiple Sclerosis, Neuromyelitis Optica
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS)…
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NCT05982925
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Caregiver Burden, Caregiver Burnout
A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer
Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions.
- Conditions
- Caregiver Burden, Caregiver Burnout, Caregiver Stress Syndrome
- Trial name
- NCT06307535
- Testing
- Meaning-Centered Psychotherapy for Caregivers, Supportive Psychotherapy for Caregivers
- Where
- 8 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Airway Disease, Interstitial Lung Disease
WTC Chest CT Imaging Archive
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016.
- Conditions
- Chronic Airway Disease, Interstitial Lung Disease, Lung Cancer
- Trial name
- NCT03295279
- Where
- United States
- Volunteers
- 2,122 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Labor
Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE
Labor analgesia is an important component of the care of laboring patients. A known side effect of combined spinal and epidural anesthesia (a type of labor analgesia) is an increased incidence of category II fetal heart rate…
- Trial name
- NCT05873218
- Testing
- Ephedrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Neutralizing Interleukin (IL)-6
The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (MDD) and evidence of…
- Trial name
- NCT07493317
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Lesion
Gadopiclenol vs Gadoxetate MRI for Liver Lesions
The overall purpose of this study is to establish noninferiority of gadopiclenol MRI compared to gadoxetate MRI in terms of image quality and lesion detection/conspicuity in patients undergoing clinically indicated liver MRI in a…
- Trial name
- NCT06596616
- Testing
- Radiology, Gadopiclenol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Metabolic Dysfunction-associated Steatotic Liver Disease
Guerbet Liver Fibrosis
The goal of this study is to assess the value of liver dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and texture analysis post gadopiclenol for liver fibrosis staging, in comparison with MR elastography, T1…
- Trial name
- NCT06703450
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Breast Cancer, Metastasis
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
- Trial name
- NCT05095207
- Testing
- Abemaciclib, Bicalutamide
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intestinal Failure
The LIFT-ECHO Last Mile Project
This is a multi-site research study to evaluate the efficacy and effectiveness of the LIFT-ECHO program to improve clinical outcomes in patients and improve patient reported quality of life (PRQOL).
- Trial name
- NCT07094308
- Testing
- Learn Intestinal Failure Tele-ECHO Program, Standard of Care
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai