Clinical trials: Escitalopram
Effort Based Decision Making, Prosocial Behavior
Effort and Antidepressant Study Test
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task…
- Conditions
- Effort Based Decision Making, Prosocial Behavior, Apathy
- Trial name
- EAST (NCT06696482)
- Testing
- Escitalopram 10mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Addiction
Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer
No medication existed for BQ dependence. No clinical trials existed for the drug therapy. Previous study showed that BQ possessed the antidepressant effect via pathway of monoamine oxidase A (MAO-A).
- Trial name
- NCT03010761
- Testing
- escitalopram, Moclobemide
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Phobic Disorders
Study of Escitalopram in the Treatment of Specific Phobia
This pilot study is designed to assess the efficacy of escitalopram in the treatment of specific phobia in adult outpatients.
- Trial name
- NCT00121069
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Connor, Kathryn M., M.D.
Depression
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
This study will evaluate changes in brain energy metabolism due to treatment with escitalopram in people with major depressive disorder.
- Trial name
- NCT00183677
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Volunteers
The Effects of Increased Central Serotonergic Activity on Information Processing
It is of great clinical relevance to know if selective serotonin re-uptake inhibitors affect information processing. Our hypothesis was that aspects of information processing would be disturbed whereas others would improve.
- Trial name
- NCT00206934
- Testing
- Escitalopram, escitaolpram
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
A Clinical Trial to Investigate the Pharmacokinetics and the Effect on ECG of Escitalopram in Elderly Volunteers
An Open-label, single dosing clinical trial to investigate the pharmacokinetics and the effect on ECG of escitalopram after oral administration in elderly volunteers.
- Trial name
- NCT02122939
- Testing
- Escitalopram
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Molecular Mechanisms of Pharmacological Action, Depression
Citalopram and Self Emotional Processing
This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mental Disorder
- Trial name
- NCT04169230
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects
Psilocybin is a classic serotonergic hallucinogen acting on the 5-HT2A receptor. It is used recreationally and in psychiatric research.
- Trial name
- NCT03912974
- Testing
- Escitalopram
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Pupillary Changes as a Potential Biomarker for Escitalopram in Relation to CYP2C19 Polymorphism
To study the impact of CYP2C19 polymorphism on escitalopram pharmacokinetics and pharmacodynamics measured as changes in pupil diameter
- Trial name
- NCT00397059
- Testing
- Escitalopram
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Stroke, Ischemic
Dose-finding Study of Selective Serotonin Reuptake Inhibitors to Enhance Neuroplasticity
The brain is able to change throughout life in response to learning, or injury, or to adapt to changes in the environment, which is known as neuroplasticity.
- Trial name
- NCT04221256
- Testing
- Administration of SSRI escitalopram, Paired Associative stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Burke Medical Research Institute
Major Depressive Disorder
A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET
This study was a non-randomized, open-label clinical study to assess Serotonin transporter occupancy in the brain of healthy adults using 11C-DASB positron emission tomography (PET)
- Trial name
- NCT06476509
- Testing
- LV232 40mg, Escitalopram 20 mg, LV232 60mg
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Healthy
Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs
To evaluate the corrected QT interval change(automatic-reading) after single oral administration of escitalopram, quetiapine and moxifloxacin versus placebo in healthy Korean Adults.
- Trial name
- NCT01871701
- Testing
- Escitalopram, Quetiapine, Moxifloxacin
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Young and Elderly Volunteers
Effects of Intravenous (IV) Citalopram on Emotional Brain Activity in Healthy Young and Elderly Adults
Antidepressant medications known as selective serotonin reuptake inhibitors (SSRIs) are most commonly prescribed to treat depression and anxiety.
- Trial name
- NCT01216449
- Testing
- Intravenous Citalopram, Normal Saline
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Rotman Research Institute at Baycrest
Major Depression
Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism
Reduction of volume of the hippocampus has been associated with major depression in many studies. It has been suggested that antidepressants may protect against hippocampus volume loss in humans associated with multiple episodes…
- Trial name
- NCT00704860
- Testing
- Open label pharmacotherapy
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Affective Disorder
Towards Neurobiology-based Diagnosis and Treatment of Affective Disorders
The project is a multi-center, prospective cohort study. The study's total targeted enrollment is 400 first-episode patients with major depressive disorder (MDD) and 400 healthy controls.
- Trial name
- NCT03294525
- Testing
- Escitalopram Pill, Duloxetine, Mirtazapine Pill
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University
Sleep Disorders
Characteristics of Sleep Patterns in Young Adults With and Without Insomnia
This study will compare the symptoms, experiences, and laboratory sleep characteristics of young adults with and without insomnia.
- Trial name
- NCT00177216
- Testing
- Zolpidem, Escitalopram
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Controls
Serotonin and Motor Plasticity
With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy…
- Trial name
- NCT03162185
- Testing
- Escitalopram
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Depressive Disorder
Pharmacotherapy and Psychotherapy for MDD After Remission on Psychology and Neuroimaging
The purpose of this study is to determine the level of residual symptoms and psychosocial factors affecting recovery of psychosocial functions in MDD patients who reach remission, and investigate the recovery process of…
- Trial name
- NCT01831440
- Testing
- medicine combined CBT, medicine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Treatment-Resistant Depression
Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology
The goal of this clinical trial is to learn about the characteristics, identify early and intervene effectively in time in Treatment-Resistant Depression.
- Trial name
- NCT05777876
- Testing
- non-invasive transcranial deep brain stimulation, Motor cortex stimulation, non-invasive transcranial deep brain stimulation with closed-loop
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diabetes, Depression
Depression-Diabetes Mechanisms: Urban African Americans
African-Americans suffer from increased prevalence of both type 2 diabetes and diabetes complications, reflecting a combination of psychobehavioral factors as well as metabolic dysfunction.
- Trial name
- NCT00209170
- Testing
- Beating the Blues, Escitalopram
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University