Clinical trials: Dexmedetomidine
Bone Fracture
A Comparative Study Between Intrathecal Dexmedetomidine VS Ketamine With Intrathecal Bupivacaine in Orthopedic Lower Limb Surgeries.
Orthopedic anaesthesia and acute postoperative pain management, two anesthesiology subspecialties,are getting more credit for reducing hospital stays, promoting functional recovery and improving patient satisfaction.
- Trial name
- NCT05751304
- Testing
- Dexmedetomidine, Ketamine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Coronary Disease
Expression Profiling of microRNA Following Administration of Dexmedetomidine
The purpose of the study is to find out the differential expression profiling of microRNA before and after adiministration of dexmedetomidine in patients undergoing procedures, and then investigators will do some in vitro studies…
- Trial name
- NCT03213743
- Testing
- Dexmedetomidine Injection
- Where
- China
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Postoperative Delirium
EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients
The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.
- Trial name
- ALPHA-DEX (NCT04443517)
- Testing
- Alpha Optimization, Emergence from anesthesia with Dexmedetomidine
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
Intrathecal Dexmedetomidine
Intrathecal Dexmedetomidine to Decrease Postoperative Nausea and Vomiting and Shivering.
Background: Highly selective α-2 agonist dexmedetomidine in increasingly used as an intrathecal adjuvant for caesarean section performed under subarachnoid block.
- Trial name
- NCT05892705
- Testing
- Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Post-Operative Analgesia, Opioid Use, Unspecified
Comparing Post-Operative Analgesic Effects of PCAM With Dexmedetomidine 1 mcg/ml vs PCAM With Dexmedetomidine 2 mcg/ml
PCA morphine have been a common method in providing excellent analgesia for post-operative period. However, the usage of morphine is not without any side effects such as nausea, vomiting, respiratory depression, and over…
- Conditions
- Post-Operative Analgesia, Opioid Use, Unspecified, Laparotomy Surgery
- Trial name
- NCT05288738
- Testing
- Dexmedetomidine 1 mcg/ml, Dexmedetomidine 2 mcg/ml
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Dexmedetomidine Versus Propofol for Sedation in Stereotactic Brain Biopsy
Pre-operative anxiety leads to higher sympathetic stimulation. Propofol in the main drug used during interventional or imaging techniques that need sedation.
- Trial name
- NCT03375385
- Testing
- dexmedetomidine/ propofol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Transurethral Resection of Prostate
Effect of Two Different Doses of Intrathecal Dexmedetomidine as Adjuvant in Elderly Patients Undergoing HoLEP
Transurethral resection of the prostate (TURP) is the most common Surgical intervention for elderly patients with benign prostatic hyperplasia.
- Trial name
- NCT05351489
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pain, Postoperative
Analgesic Efficacy of Ultrasound Guided Erector Spinae Block for Modified Radical Mastectomy
To compare the analgesic efficacy of dexmedetomidine and magnesium sulphate as adjuvants to levobupivacaine in erector spinae plane block in modified radical mastectomy surgery for acute and chronic pain management.
- Trial name
- NCT04732364
- Testing
- ultrasound guided erector spinae plan block using bupivacaine for modified radical mastectomy, ultrasound guided erector spinae plan block with bupivacaine and Dexmetonidine for modified radical mastectomy, ultrasound guided erector spinae plan block with bupivacaine and magnesium slphate for modified radical mastectomy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- South Egypt Cancer Institute
Brain Glioma, Midazolam
The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas
It has been shown through functional MRI (Magnetic Resonance Imaging) that patients with gliomas in eloquent areas have compensated neurological function by virtue of brain post-injury reorganization.
- Conditions
- Brain Glioma, Midazolam, Dexmedetomidine
- Trial name
- NCT03984240
- Testing
- Midazolam, Dexmedetomidine
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Hip Arthropathy, Hip Disease
Cardiac Index and General Anesthesia Without Opioid.
General anesthesia used to be based on the association of hypnotics and opioid drugs. But recent studies showed that opioids may be related to a many different complications, like respiratory distress, hyperalgesia.
- Trial name
- OFFLOW (NCT05446623)
- Testing
- Dexmedetomidine, Sufentanil
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Montauban
Anesthesia
Effect of Dexmedetomidine of Gastrointestinal Motility
Anorectal manometry requires that the patient be able to respond to command and not receive any medications which could alter muscle tone or motility.
- Trial name
- NCT04798482
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Collapse of Thoracic Vertebra, Collapse of Lumbar Vertebrae
Study of Dexmedetomidine in Spine Surgery
The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups.
- Trial name
- NCT01850017
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Total Knee Arthroplasty, Sedation
The Effect of Sedation on Rebound Pain in Knee Arthroplasty
Dexmedetomidine is often used for sedation procedures. It has also been shown to have a pain-protective effect. Researchers predicted that using dexmedetomidine for sedation in total knee arthroplasties performed under spinal…
- Trial name
- NCT06555458
- Testing
- Dexmedetomidine, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Dexmedetomidine Induced Sedation
Combined Electroencephalogram, Magnetic Resonance Imaging-Positron Emission Tomography of Dexmedetomidine Induced Sleep
The investigators are doing this research study to find out how and where dexmedetomidine, a sedative anesthetic, acts in the brain.
- Trial name
- NCT01485380
- Testing
- dexmedetomidine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Failed Conscious Sedation During Procedure
Controlled Sedation for Cataract Surgery
This study evaluates the surgeon and patient´s satisfaction who undergoes cataract surgery using either dexmedetomidine or remifentanil as sedation
- Trial name
- NCT03401606
- Testing
- remifentanil, Dexmedetomidine
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Inflammation, Cancer
Dexmedetomidine and HIPEC
Inflammation is associated with an increased risk of cancer recurrence. Various methods have been used to decrease the inflammatory response induced by the cancer and surgery.
- Trial name
- NCT04106999
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postoperative Nausea and Vomiting
Adjuvant Effect of Dexmedetomidine in Ultrasound (USG) Guided Transvers Abdominis Plane Block
A total of 60 adult patients American Society of Anesthesiologists physical status I,II, III were randomized to Group B (n = 30) receiving TAP block with 0.25% bupivacaine and Group D (n = 30) with 0.5 mcg/kg dexmedetomidine…
- Trial name
- USG (NCT02331563)
- Testing
- Dexmedetomidine, 0.25 % bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kırıkkale University
Precedex Effect to Propofol Requirement
The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway
Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough…
- Trial name
- NCT02284672
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Postoperative Delirium
Dexmetomedine for Post Operative Delirium in Elderly Patients Undergoing Elective Total Knee Replacement Under Spinal Anesthesia
Postoperative delirium is a geriatric syndrome occurring after anesthesia and surgery which manifests as acute alterations in mental status, involving changes in cognition, attention, and levels of consciousness that tend to…
- Trial name
- NCT05707741
- Testing
- dexmetomedine infusion
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Labor Pain
Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using…
- Trial name
- NCT05781854
- Testing
- Epidural analgesia with bupivacaine and dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University