Clinical trials: sponsored by Chinese University of Hong Kong
Metabolic Dysfunction-associated Steatotic Liver Disease
Digital Pathology and AI for Liver Outcomes in MASLD
The aim of this multi-center, retrospective epidemiologic study is to confirm the prognostic performance of the Digital Pathology (DP) FibroNest Phenotypic Fibrosis Composite Score (Ph-FCS), derived from standard digital…
- Trial name
- DPAILO-1 (NCT06344364)
- Testing
- Digital Pathology FibroNest Phenotypic Fibrosis Composite Score (Ph-FCS)
- Where
- 3 sites in Hong Kong, Spain
- Volunteers
- 1,241 people
- Sponsor
- PharmaNest, Inc
Bladder Neoplasm
Virtuoso Improving Anatomic Bladder Lesion Excision (VIABLE) Trial
A robotic assisted surgery for bladder lesion excision.
- Trial name
- NCT06940648
- Testing
- The study is to evaluate the use of the Virtuoso Endoscopy System to perform safe and effective bladder lesion excisions.
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Virtuoso Surgical, Inc.
High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities
The goal of this clinical trial is to learn if an investigational vaginal suppository therapy works to treat low-grade cervical lesions (ASC-US and LSIL) associated with high-risk human papillomavirus (hr-HPV) infection in women.
- Conditions
- High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion, ASC-US, HPV Infection
- Trial name
- NCT07572396
- Testing
- EGCG and Quinine Sulfate Vaginal Suppository
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Amplexd Therapeutics, Inc.
Diabete Type 2
Safety, Tolerability and Preliminary Efficacy of Sublingual Liraglutide in Patients With Type 2 Diabetes Mellitus
This is a phase Ib/IIa, single ascending dose study of the safety, tolerability and preliminary efficacy of sublingual (SL) Liraglutide in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT05268237
- Testing
- Liraglutide
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Biolingus
Allergy to Fish, Allergy to Shrimp
Pilot Study on Traditional Chinese Medicine and Food Allergy
Recently, there has been an increasing interest in using traditional Chinese medicine for food allergy. The Harvard group has successfully demonstrated the Food Allergy Herbal Formula - FAHF2 completely blocked peanut-induced…
- Conditions
- Allergy to Fish, Allergy to Shrimp, Allergy to Crab
- Trial name
- TCMFA (NCT02490813)
- Testing
- Treatment - Chinese Herbal Formula - X
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hong Kong Sanatorium & Hospital
Influenza Type A, Influenza Type B
Influenza A+B Test Kit Performance Study
Prospective clinical study on the performance of an Influenza A+B rapid test kit. The main goal is to establish the sensitivity and specificity (i.e. how accurate the test is) when compared to a gold standard.
- Trial name
- NCT03895268
- Testing
- ALiA Analyser, Influenza A+B Test Kit
- Where
- Hong Kong
- Volunteers
- 600 people
- Sponsor
- Sanwa BioTech Limited
Hepatocellular Carcinoma
Efficacy Study of Pegylated Recombinant Human Arginase 1 as a Second-line Therapy in Patients With Advanced Liver Cancer
The purpose of the study is to evaluate the efficacy and safety of PEG-BCT-100 as the second-line therapy following sorafenib in advanced HCC patients.
- Trial name
- NCT02089763
- Testing
- pegylated recombinant human arginase
- Where
- Hong Kong
- Volunteers
- 27 people
- Sponsor
- Bio-Cancer Treatment International Limited
Asthma, Mastocytosis
Mast Cell Activation Test in Allergic Disease
Activation of mast cells in the immune system is known to cause allergic reactions sometimes with severe systemic symptoms. The investigators have recently developed a blood-based mast cell activation diagnostic test in which…
- Conditions
- Asthma, Mastocytosis, Mast Cell Activation Syndrome, Food Allergy
- Trial name
- NCT03406325
- Where
- Hong Kong
- Volunteers
- 19 people
- Sponsor
- Hong Kong Sanatorium & Hospital
Healthy
Clinical Bioequivalence Study on Two Paracetamol Tablet Formulations
The objective of the study is to compare the bioavailability of a generic product of paracetamol (immediate-release) with that of a reference product when administered to healthy volunteers under fasting condition.
- Trial name
- NCT03562780
- Testing
- Fortolin Tab 500mg, Panadol Caplet 500mg
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fortune Pharmacal Co., Ltd.
Healthy
Clinical Bioequivalence Study on Two Metoprolol Tablet 100mg Formulations
The purpose of the study is to compare the bioavailability of a generic product of metoprolol with that of a reference product when administered to healthy volunteers under fasting conditions.
- Trial name
- NCT03082352
- Testing
- BF-Metoprolol Tablet 100mg, Betaloc Tablet 100mg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited
Healthy
Clinical Bioequivalence Study on Two Lisinopril Tablets 20mg Formulations
The objective of the study is to compare the bioavailability of a generic product of lisinopril with that of a reference product when administered to healthy volunteers under fasting condition.
- Trial name
- NCT03599466
- Testing
- BF-Lisinopril Tablets 20mg, Zestril Tab 20mg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited
Hypoxic-Ischemic Encephalopathy, Hypoxia Neonatal
Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia
The study is to investigate the feasibility and safety of autologous umbilical cord blood transfusion to treat the newborn infants with presence of clinical indications of neonatal hypoxic-ischemia encephalopathy (HIE) and…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hypoxia Neonatal, Cerebral Ischemia of Newborn, Anemia, Neonatal
- Trial name
- NCT03352310
- Testing
- autologous umbilical cord blood (UCB), standard care
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Mononuclear Therapeutics Ltd.
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Great China Fatter Liver Consortium (GC_FLC) Study to Assess the Progress of NAFLD/NASH in Chinese
Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease ranging from simple steatosis to cirrhosis of the liver.
- Trial name
- NCT03282305
- Volunteers
- 5,000 people
- Sponsor
- Great China Fatty Liver Consortium Limited
Healthy
Clinical Bioequivalence Study on Two Methyldopa Tablet 250mg Formulations
The objective of the study is to compare the bioavailability of a generic product of methyldopa with that of a reference product when administered to healthy volunteers under fasting condition.
- Trial name
- NCT03210025
- Testing
- BF-Methyldopa 250mg Tablet, Metopa Tab 250mg
- Where
- Hong Kong
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited
Healthy
Clinical Bioequivalence Study on Two Amlodipine Tablet 10mg Formulations
The purpose of the study is to compare the bioavailability of a generic product of amlodipine with that of a reference product when administered to healthy volunteers under fasting conditions.
- Trial name
- NCT02707913
- Testing
- BF-Amlodipine Tablet 10mg, Norvasc Tablet 10mg
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited
Healthy
Clinical Bioequivalence Study on Two Gliclazide 80mg Tablet Formulations
The purpose of the study is to compare the bioavailability of a generic product of gliclazide (Product Name: BF-Gliclazide Tablet 80mg, Manufactured by Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical…
- Trial name
- NCT02643329
- Testing
- BF-Gliclazide Tablet 80mg, Diamicron 80mg Tablet
- Where
- Hong Kong
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited
Neoplasm, Hepatocellular Carcinoma
Study of Pegylated Human Recombinant Arginase for Liver Cancer (BCT-100-002)
The purpose of this study is to determine whether recombinant human arginase (PEG-BCT-100) is safe and effective in the treatment of advanced hepatocellular carcinoma (HCC).
- Trial name
- BCT-100-002 (NCT01092091)
- Testing
- Pegylated Recombinant Human Arginase I
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Bio-Cancer Treatment International Limited
Neoplasm, Hepatocellular Carcinoma
Study of Pegylated Human Recombinant Arginase for Liver Cancer
The purpose of this study is to determine whether recombinant human arginase (PEG-BCT-100) is safe and effective in the treatment of advanced hepatocellular carcinoma (HCC).
- Trial name
- NCT00988195
- Testing
- Pegylated Recombinant Human Arginase I, Doxorubicin
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Bio-Cancer Treatment International Limited
Advanced Hepatocellular Carcinoma
XIAP Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)
AEG35156 is a second generation antisense which targets XIAP mRNA to lower XIAP levels and the apoptotic threshold of cancer cells, enhancing their sensitivity to intrinsic death and chemotherapy.
- Trial name
- NCT00882869
- Testing
- AEG35156 antisense IV infusion, Sorafenib
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- Aegera Therapeutics