Clinical trials: Remifentanil
Ventilation Therapy; Complications, Trachea
Comparison Between VCV and FCV Through Ultra-thin Tube in Upper Airway Surgery
Ventilation through the small endotracheal tube is not an uncommon situation. The indications for it differ from elective upper airway surgery to emergency ventilation through needle cricothyrotomy.
- Trial name
- NCT05033730
- Testing
- Flow Controlled Ventilation
- Where
- Qatar
- Volunteers
- 30 people
- Sponsor
- Hamad Medical Corporation
Hyperalgesia
Hyperalgesia and Pain
Evaluation of the effects of 35%/15%/50% N2O/N2/O2 mixtures on the area of hyperalgesia induced by remifentanil in the CCES (Continuous Cutaneous Electrical Stimulation) model in 20 healthy volunteers.
- Trial name
- NCT01581450
- Testing
- Nitrous Oxide
- Where
- 2 sites in Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Air Liquide Santé International
Anesthesia, Intravenous
Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery
A phase III confirmatory trial evaluating the efficacy and safety of remimazolam (CNS7056) compared to propofol for intravenous anesthesia during elective surgery in ASA Class III/IV patients.
- Trial name
- NCT03661489
- Testing
- Remimazolam, Propofol
- Where
- Germany
- Volunteers
- 469 people
- Sponsor
- Paion UK Ltd.
Intubating Conditions, Postoperative Myalgia
Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex.
- Conditions
- Intubating Conditions, Postoperative Myalgia, Patient Satisfaction
- Trial name
- NCT01996358
- Testing
- Succinylcholine, Rocuronium 0,3, Rocuronium 0,6
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Analgesia
Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
This study will be a multicentre randomized, open-label, phase IIIb study. This study will evaluate two different techniques of sedation: an analgesia based regimen with remifentanil versus a conventional sedation based regimen…
- Trial name
- NCT00436345
- Testing
- Remifentanil, Propofol
- Where
- 6 sites in Italy
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
Sedation
Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects
The study will evaluate the pharmaco-economic consequences of the use of a remifentanil based regimen compared with a conventional sedative based regimen in terms of duration of mechanical ventilation, length of stay in ICU…
- Trial name
- NCT00158873
- Testing
- midazolam, lorazepam, fentanyl
- Where
- 15 sites in Netherlands
- Volunteers
- 224 people
- Sponsor
- GlaxoSmithKline
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia
Improving Information Extraction From EEG on Cerebral Anesthetic Drug Effects
This is an interventional, randomized controlled study in health volunteers that involves collecting data on raw EEG waves measuring various combinations of anesthetic drugs during standardized drug titration.
- Trial name
- NCT02043938
- Testing
- SedLine EEG sensor
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Anesthesia
Bispectral Index and Levels of Sedation With Propofol With/Without Remifentanil in Healthy Volunteers (SONORA)
The purpose of this study is investigate the relationship between BIS™ and propofol with/without remifentanil across a wide range of hypnotic states.
- Trial name
- SONORA (NCT04466384)
- Testing
- BIS
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Long-Eye Surgeries
Remifentanil and Remimazolam to Limit Patient Movement
Local anesthetics (LA) may be administered by injection (retrobulbar, peribulbar, subconjunctival, lid, or facial block) or by instillation (topical anesthesia), Considerable drawbacks of local anesthesia in these patients…
- Trial name
- NCT06583811
- Testing
- Remifentanil
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Egymedicalpedia
Acute Pain, Chronic Pain
Acute and Chronic Pain, Especially Neuropathic Pain, After Thoracotomy and Continuous Application of Ketamine.
Chronic Pain, especially neuropathic pain, are adverse events after posterolateral thoracotomy for lung resection. The continuous application of ketamine may have a prophylactic effect and helps to prevent chronic pain.
- Conditions
- Acute Pain, Chronic Pain, Neuropathic Pain
- Trial name
- NCT03105765
- Testing
- Ketamine
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Pain
Experimental Medicine Study to Validate Pharmacodynamic Pain Assessments in Healthy Volunteers With an Opioid Analgesic (Remifentanil)
This was a single centre, randomised, double blind, placebo controlled, two-way cross-over design study to assess the feasibility of pain PD tests and to determine the variability and effects of a known analgesic drug (the opioid…
- Trial name
- NCT02602002
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
High Sensitive Troponin T Release
Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic Surgery
It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties.
- Trial name
- NCT02217319
- Testing
- Sevoflurane, TIVA
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Intubating Conditions, Performance With Respiratory Exercise Device
Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with neostigmine.
- Conditions
- Intubating Conditions, Performance With Respiratory Exercise Device, Postoperative Myalgia
- Trial name
- NCT01966484
- Testing
- Succinylcholine, Mivacurium
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Atrial Fibrillation, Neuropathic Pain
Atrial Fibrillation and Neuropathic Pain After Thoracotomy and Continuous Application of Magnesium Sulphate.
Atrial fibrillation and chronic neuropathic pain are adverse events occurring after posterolateral thoracotomy for lung resection. The continuous application of magnesium sulphate may have a prophylactic effect.
- Trial name
- NCT02008747
- Testing
- Magnesium sulphate
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Abirritation in the ICU
A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU)
The purpose of this study is to evaluate the efficacy and safety of Tegileridine Fumarate lnjection for prolonged abirritation(48h to 72h) during mechanical ventilation in the ICU.
- Trial name
- NCT07372924
- Testing
- Tegileridine Fumarate lnjection, Remifentanil Hydrochloride for Injection
- Where
- 2 sites in China
- Volunteers
- 121 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
General Anesthesia
Remimazolam Phase II Cardiac Anesthesia Study
This phase II study in patients undergoing elective cardiac surgery will evaluate the efficacy, safety, and pharmacokinetics of remimazolam, compared with propofol and sevoflurane, during the induction and maintenance of general…
- Trial name
- NCT01937767
- Testing
- Remimazolam, Propofol, Sevoflurane
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Paion UK Ltd.
Efficacy and Safety of Mivacurium Chloride for Pediatric Patients
A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients
To evaluate the effect and safety of mivacurium chloride in pediatric patients.
- Trial name
- NCT02117401
- Testing
- mivacurium chloride, midazolam, ketamine
- Volunteers
- 1,152 people
- Sponsor
- Jiangsu Nhwa Pharmaceutical Co., Ltd.
Anesthesia
A Study to Evaluate the Safety and Efficacy of Ultiva (Remifentanil Hydrochloride) in Pediatric Participants General Anesthetised
The purpose of this study is to evaluate the efficacy and safety of JNJ-268229 (Ultiva /Remifentanil Hydrochloride) in pediatric participants between 1 and 15 years of age during maintenance of general anesthesia.
- Trial name
- NCT01998165
- Testing
- Remifentanil
- Where
- 9 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Janssen Pharmaceutical K.K.
Anesthesia
Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil
This trial is designed to quantify the pharmacodynamic (PD) and pharmacokinetic (PK) interaction(s) between an anaesthetic drug (remimazolam) and an opioid (remifentanil).
- Trial name
- NCT04670471
- Testing
- Remimazolam, Remifentanil
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Paion UK Ltd.