Clinical trials: Bevacizumab
- Drug or intervention Bevacizumab
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Healthy
To Demonstrate Similarity of Pharmacokinetics and Evaluate Safety of CT-P16, EU-Approved Avastin and US-licensed Avastin
This study is a Phase 1 Randomized, Double-blind, Three-arm, Parallel Group, Single-dose Study to compare the PK, safety and immunogenicity of the proposed biosimilar test product CT-P16 with EU-approved Avastin and US-licensed…
- Trial name
- NCT03247673
- Testing
- CT-P16, EU-approved Avastin, US-licensed Avastin
- Where
- 3 sites in South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Celltrion
Healthy
A Study to Compare Pharmacokinetic and Safety of TRS003 to China-approved Bevacizumab and US-licensed Avastin®
This is a 12-week, randomized, double-blind, single-dose pharmacokinetic (PK) study. Approximately 114 healthy male participants (screening occurred within 28 days prior to dosing) will be randomized 1:1:1 to either TRS003…
- Trial name
- NCT03882424
- Testing
- TRS003, China-approved Bevacizumab, US-licensed Avastin
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Zhejiang Teruisi Pharmaceutical Inc.
Healthy Volunteers
Pharmacokinetic Study Comparing MB02 And US And EU Avastin® In Healthy Male Volunteers
Randomized, double blind, parallel group, single dose, 3 arm study to investigate and compare the pharmacokinetics (PK), safety and immunogenicity profile of MB02 with US and EU Avastin® in healthy male subjects.
- Trial name
- NCT04238663
- Testing
- MB02 (Bevacizumab Biosimilar), EU approved Avastin®, US licenced Avastin®
- Where
- Germany
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- mAbxience Research S.L.
Healthy Volunteers
To Demonstrate Equivalent Pharmacokinetic Properties of HD204 and Bevacizumab (Avastin®) in Healthy Male Subjects
The purpose of this study is to compare the pharmacokinetics, as well as to evaluate the safety, tolerability and immunogenicity of HD204, US-Avastin and EU-Avastin in healthy male subjects after intravenous administration of a…
- Trial name
- NCT03390673
- Testing
- HD204, Avastin
- Where
- 2 sites in New Zealand
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Prestige Biopharma Limited
Healthy Volunteers
A Study Comparing the Pharmacokinetic Similarity of MB02-SP, MB02-DM and US Licensed-Avastin®.
Randomized, double blind, parallel group, single dose, 3 arm study to investigate and compare the PK, safety and immunogenicity profile of MB02-DM with MB02-SP and US-Avastin® in healthy male subjects.
- Trial name
- NCT04408989
- Testing
- MB02-SP, MB02-DM, US licenced Avastin®
- Where
- 2 sites in New Zealand
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- mAbxience Research S.L.
Locally Recurrent and Metastatic Breast Cancer
Phase 2 Study of AMG 386 Plus Paclitaxel With or Without Bevacizumab as First Line Therapy in Her2-Negative Breast Cancer Patients
This is a phase 2, randomized, placebo controlled, multi-center study to estimate the treatment effect and evaluate the safety and tolerability of AMG 386 in combination with paclitaxel and paclitaxel/bevacizumab in the treatment…
- Trial name
- NCT00511459
- Testing
- AMG 386, Bevacizumab, Paclitaxel
- Where
- 77 sites in United States, Australia and 11 more
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Amgen
Healthy
A Pharmacokinetic Study Comparing PF-06439535 And Bevacizumab In Healthy Male Volunteers (REFLECTIONS B739-01)
This study is to prove that the handling (also referred to as pharmacokinetics) of the following drugs PF-06439535, Avastin® (bevacizumab) that is licensed for use in the United States (bevacizumab-US) and Avastin® (bevacizumab)…
- Trial name
- NCT02031991
- Testing
- PF-06439535, Avastin
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Pharmacokinetics and Safety Study of ASKB1202 in Chinese Healthy Subjects
This trial will investigate the pharmacokinetic,immunogenicity and safety biosimilarity of ASKB1202 compared to bevacizumab sold in China and Europe.
- Trial name
- NCT03115762
- Testing
- bevacizumab, ASKB1202
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Jiangsu Aosaikang Pharmaceutical Co., Ltd.
Healthy
Compare IBI305 and Bevacizumab on Pharmacokinetics/Safety/Immunogenicity on Healthy Male
To confirm the PK similarity of IBI305 and bevacizumab in healthy volunteers .
- Trial name
- NCT03083990
- Testing
- IBI305(Bevacizumab Biosimilar), Avastin(Bevacizumab)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Healthy
Bioequivalence and Safety Study of Bevacizumab-biosimilar (RPH-001) Compared to Bevacizumab-innovator
The purpose of this to assess pharmacokinetic bioequivalence between two bevacizumab products, RPH-001 (TRPHARM) and EU sourced Avastin® (Roche), after single IV administration at 5 mg/kg fixed dose.
- Trial name
- NCT03131700
- Testing
- RPH001, Avastin®
- Volunteers
- healthy volunteers welcome
- Sponsor
- TRPHARM
Healthy
Pharmacokinetic Equivalence and Safety Study of RPH-001 and Avastin®
The purpose of this study is to confirm pharmacokinetic equivalence and compare clinical safety profile of RPH-001 and Avastin®.
- Trial name
- NCT03659305
- Testing
- RPH-001, Avastin
- Where
- Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- R-Pharm
Healthy Male
A Study Comparing SIBP-04 and Bevacizumab in Healthy Male Subjects
This is a randomised, double-blind, positive drug parallel controlled clinical trial in China. In the trial, it is planned to enroll 88 subjects, randomized to two treatment groups in a ratio of 1:1 to receive the test drug and…
- Trial name
- NCT04135898
- Testing
- SIBP-04, Bevacizumab
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Retinal Vein Occlusion, Macular Edema
A Retrospective Study of Anti-Vascular Endothelial Growth Factor (VEGF) Injections for Retinal Vein Occlusion or Diabetic Macular Edema
This retrospective data review study will evaluate anti-VEGF injections for retinal vein occlusion (RVO) or diabetic macular edema (DME).
- Trial name
- NCT01918371
- Testing
- Anti-VEGF
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Allergan
Non-small Cell Lung Cancer
Clinical Trial in Chinese Healthy Volunteers of GB222
The primary objective of this study is to evaluate the similarity of the primary pharmacokinetic (PK) parameter AUC0-t of GB222 and bevacizumab after single administration; the secondary objective is to observe the safety and…
- Trial name
- NCT04175158
- Testing
- GB222, Bevacizumab
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Genor Biopharma Co., Ltd.
Healthy Male Subjects
Study of Bevacizumab With Different Manufacturing Process in Healthy Male Subjects
The purpose of this study is to evaluate the pharmacokinetic similarity of bevacizumab with different manufacturing process in healthy male subjects.
- Trial name
- NCT05005455
- Testing
- bevacizumab with new manufacturing process., bevacizumab with old manufacturing process.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
NSCLC
Study of Bevacizumab(BAT1706) and Comparators in Healthy Subjects
The purpose of this study is to establish PK similarity in the treatment of BAT1706 and comparators.
- Trial name
- NCT03030430
- Testing
- BAT1706 injection, EU-sourced Avastin, US-sourced Avastin
- Where
- New Zealand
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Bio-Thera Solutions
Pharmacokinetics, Safety Issues
A Phase I Study Comparing Pharmacokinetics and Safety of Bevacizumab
The aim of the Clinical study is to evaluate the pharmacokinetic and safety profile of a new formulation of Bevacizumab (Zutrab®, Argentinian origin) when compared to two already marketed formulations of Bevacizumab Avastin®…
- Trial name
- NCT03919448
- Testing
- Bevacizumab
- Where
- Argentina
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Healthy
Phase I - Pharmacokinetic Comparability Study in Healthy Male Volunteers
Double-blind, single-dose, three-treatment, parallel group design PK comparability study of MYL-1402O solution manufactured for Mylan compared to US and EU marketed Avastin® solution (bevacizumab).
- Trial name
- NCT02469987
- Testing
- MYL-1402O, US marketed Avastin(R), EU marketed Avastin(R)
- Where
- Netherlands
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Mylan Inc.
Healthy
Pharmacokinetic, Safety, Tolerability, and Immunogenicity Study of SB8 in Healthy Male Subjects
Pharmacokinetics, Safety, Tolerability, and Immunogenicity of Three Formulations of Bevacizumab
- Trial name
- NCT02453672
- Testing
- SB8, EU sourced Avastin®, US Sourced Avastin®
- Where
- Belgium
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Samsung Bioepis Co., Ltd.
Healthy Male Subjects
A Study to Compare the Pharmacokinetics of JHL1149 and Bevacizumab (Avastin) in Healthy Male Volunteers
This is a Phase I, Double-blind, Randomized, Parallel-group, Single-dose, Three-Arm Study to Compare the Pharmacokinetics and to Evaluate the Tolerability, Safety and Immunogenicity of JHL1149 and Bevacizumab (Avastin) Sourced…
- Trial name
- NCT03576651
- Testing
- JHL1149, Bevacizumab
- Where
- Bulgaria
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- JHL Biotech, Inc.