Clinical trials: in Uruguay
Photobiomodulation, Endodontic Disease
Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery
The objective of this study will be to evaluate if photobiomodulation (FBM) can reduce postoperative pain in patients who will undergo endodontic surgery.
- Conditions
- Photobiomodulation, Endodontic Disease, Pain, Inflammation
- Trial name
- NCT05935306
- Testing
- Ibuprofen, Photobiomodulation simulation, Photobiomodulation
- Where
- Uruguay
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Glycemic Responses
Blood Glucose Response to Test Foods Containing Brewer's Spent Grain
The objective of this project is to determine the impact of incorporating brewers' spent grain into cookie formulations on postprandial blood glucose absorption levels following consumption.
- Trial name
- BSG-PPG (NCT07446179)
- Testing
- Food Intervention
- Where
- Uruguay
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Católica del Uruguay
Neutropenia
Biosimilarity Study of Subcutaneous Pegfilgrastim in Healthy Volunteers
This study will compare the pharmacokinetics and pharmacodynamics, after single subcutaneous application, in healthy men, between pegfilgrastim formulation, produced by Megalabs (test product) and Neulastim® (reference product)…
- Trial name
- NCT04873765
- Testing
- Pegfilgastrim Megalabs, Pegfilgastim Amgen
- Where
- Uruguay
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Megalabs
Periodontitis, Fistula
Evaluation of Photodynamic Therapy in Pieces With Presence of Fistula.
The goal of this clinical trial is to learn if adjuvant antimicrobial photodynamic therapy (aPDT) can help in the treatment in patients with pieces with apical periodontitis and the presence of fistula, in terms of reducing…
- Trial name
- aPDT (NCT06413836)
- Testing
- aPDT, Endodontic treatment
- Where
- Uruguay
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Lactulose, Polyethylene Glycol
Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults
Colonoscopy is the gold standard in bowel assessment when there is suspicion of colon and rectum pathology. Bowel cleansing is necessary to ensure an optimal visualization of colonic mucosa, allowing this form of detection and…
- Conditions
- Lactulose, Polyethylene Glycol, Bowel Preparation, Colonoscopy
- Trial name
- NCT05726344
- Testing
- Lactulose, Polyethylene Glycol 3350
- Where
- Uruguay
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Dental Caries in Children
Pandemic-adapted Caries Care Multicentre Single-group Interventional Study
The current understanding of dental caries has not been completely transferred into the clinical practice to control caries lesion progression (severity / activity) and the individual risk of caries.
- Trial name
- NCT04666597
- Testing
- Modified CariesCare International management
- Where
- 21 sites in United States, Argentina and 11 more
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Caries,Dental
Photobiomodulation on Major Salivary Glands in Children With Caries Activity
The purpose of this trial is to evaluate the efficacy of photobiomodulation of the major salivary glands on salivary parameters in children with caries activity.
- Trial name
- NCT05546528
- Testing
- Photobiomodulation
- Where
- Uruguay
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Postoperative Complications, Mortality
Latin American Surgical Outcomes Study
Methods: International, seven-day observational cohort study of complications following elective or emergency surgery. Objectives: To provide detailed data describing post-operative complications and associated mortality.
- Trial name
- LASOS (NCT05169164)
- Testing
- No intervention, observational
- Where
- Uruguay
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fresh Sockets With Buccal Resorption
Immediate Dentoalveolar Restoration Compared to Bio-oss
This randomised controlled trial compares the immediate dentoalveolar restoration and bovine demineralised bone in immediate implants placed in fresh sockets with buccal resorption.
- Trial name
- IDRBio-oss (NCT03202030)
- Testing
- Immediate dentoalveolar restoration, Demineralized bovine bone
- Where
- Uruguay
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
End Stage Liver Disease, Rejection
Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant Patients
To search for suitable pharmacodynamic biomarkers, i.e., with high specificity for calcineurin inhibition and most affected by inter-individual variability, our works aimed at exploring the pharmacodynamics of CNI, the strength…
- Conditions
- End Stage Liver Disease, Rejection, Infection, Malignancy
- Trial name
- 3PIGREF (NCT01760356)
- Where
- Uruguay
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- UDA Centro Nacional Hepato-Bilio-Pancreático
Sedentary Behavior, Mental Health Wellness 1
Influence Physical Activity Psychological Responses COVID-19 Pandemic
The on-going Wuhan coronavirus (COVID-19) outbreak has become the world's leading health headline and is causing major panic and public concerns.
- Trial name
- NCT04352517
- Testing
- Online Survey
- Where
- 3 sites in Brazil, Chile and 1 more
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Diet Habit, Weight, Body
Eating and Physical Activity Patterns of the Population Working in the Uruguayan State Electrical Company.
Stuydy of eatin and physical activity patterns in Uruguayan workers and association with obesity, overweight, and tasks.
- Trial name
- PAF (NCT04509908)
- Where
- Uruguay
- Volunteers
- 1,964 people, healthy volunteers welcome
- Sponsor
- Administración Nacional de Usinas y Transmisiones Eléctricas
Hypertension
Telemonitoring of Uncontrolled Hypertension
The proportion of hypertensive patients achieving adequate blood pressure control meeting guideline targets remains low. Of those patients on blood pressure lowering drugs, only 50% reach control. Objectives: 1.
- Trial name
- ERNESTINA (NCT02730052)
- Testing
- Omron 9200T plus Telemonitoring, Omron 9200T without Telemonitoring
- Where
- 8 sites in Argentina, Uruguay
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad de la Republica
Lead Toxicity
Iron Supplementation of Lead-exposed Infants
The purpose of this study is to compare the efficacy of iron (12.5 mg as ferrous sulfate) and placebo given for 6 months in preventing the elevation of blood lead concentration in children 6-9 months of age.
- Trial name
- NCT00374790
- Testing
- Ferrous sulfate
- Where
- Uruguay
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cornell University
Carnitine; Muscle, Functional Status
Impact on Functional Status in Older Adults Treated With L-Carnitine
This study evaluates the impact of the treatment with L-Carnitine on the function of adults over 65 years, in conjunction with regular exercise.
- Conditions
- Carnitine; Muscle, Functional Status, Old Age; Debility
- Trial name
- NCT03180424
- Testing
- L Carnitine, Supervised exercise, Exercise at home
- Where
- Uruguay
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Bio-equivalence Study, Fed Conditions
Fed Bioequivalence Study of CBZ Formulations
Controlled release Carbamazepine (CBZ) is a antiepileptic, antineuralgic and mood stabilizer drug. The CR formulation of CBZ is slowly absorbed and the elimination half life varies with time due to metabolism autoinduction.
- Trial name
- NCT02132897
- Testing
- Auration CR Tablets 400 Single Dose-Tegretol CR 400 Single Dose, Tegretol CR 400 Single Dose-Auration CR 400 Single Dose
- Where
- Uruguay
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Center for Clinical Pharmacology Research Bdbeq S.A.
Healthy
Efavirenz Comparative Bioavailability
The primary objective of this study is to determine the average bioequivalence of a generic efavirenz 600 mg tablet (test formulation)compared with Stocrin(R) 600 mg tablets (Reference formulation).The study is designed as an…
- Trial name
- efv600 (NCT01704898)
- Testing
- Efavirenz 600 Test-Stocrin 600 Reference, Stocrin 600 Reference-Efavirenz 600 Test
- Where
- Uruguay
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Clinical Pharmacology Research Bdbeq S.A.
Bioequivalency
Single Dose Bioequivalence Study of Darifenacin Tablets 7.5 mg in Fed Healthy Volunteers.
The proposed study was designed as a randomized two-sequence, two period crossover trial to assess the bioequivalence, pharmacokinetic profiling and safety of a brand generic formulation of darifenacin [Darisec(R) 7.5 mg] vs.
- Trial name
- NCT01229280
- Testing
- Darifenacin
- Where
- Uruguay
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Center for Clinical Pharmacology Research Bdbeq S.A.
Bioequivalency
Single Dose Two-periods Crossover Bioequivalence Study of Darifenacin Tablets in Healthy Volunteers.
The present study was designed to assess the bioequivalence and pharmacokinetic profiling of a brand generic formulation of darifenacin [Darisec(R)]vs. the innovator [Enablex(R)]in healthy volunteers after a high fat breakfast.
- Trial name
- NCT01227811
- Testing
- Darifenacin
- Where
- Uruguay
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Center for Clinical Pharmacology Research Bdbeq S.A.
Postpartum Hemorrhage
Controlled Cord Traction During Third Stage of Labor
Of the estimated number of 529,000 maternal deaths for the year 2000, 132,000 (25%) were caused by postpartum hemorrhage (PPH); 99% of these deaths occurred in low-income countries.
- Trial name
- CCT (NCT00781066)
- Testing
- Controlled cord traction, No controlled cord traction
- Where
- 2 sites in Uruguay
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad de la Republica