Clinical trials: completed, in United States
Blood Glucose, GLP-1
Slowly Digestible Carbohydrates for GLP-1 Secretion
The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults.
- Conditions
- Blood Glucose, GLP-1, Satiety, Second Meal Intake
- Trial name
- NCT07572513
- Testing
- Raw Corn Starch
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Purdue University
Venous Embolism of Lower Extremities (Diagnosis), Arterial Embolism and Thrombosis
Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System
The purpose of Case-Specific Health Care Professional (HCP) Clinical Survey of Liberant™ Thrombectomy System, also known as the Liberant Clinical Assessment, is to collect first-in-human clinical data to confirm the safety and…
- Conditions
- Venous Embolism of Lower Extremities (Diagnosis), Arterial Embolism and Thrombosis, Acute DVT of Lower Extremity, Chronic DVT of Lower Extremity
- Trial name
- NCT07335341
- Testing
- Liberant Thrombectomy System
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Medtronic Endovascular
Colorectal Cancer Screening, Diabetes Mellitus, Type 2
Aim 3, Optimizing CRC Screening in Patients With Diabetes in Safety-net Primary Care Settings
This mixed methods study evaluates the effectiveness and feasibility of a multi-level (patient, team, organizations) intervention to optimize CRC screening for patients with diabetes in primary care safety-net settings.
- Trial name
- NCT05785780
- Testing
- Targeted CRC Screening Toolkit
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Hypoglycemia
Differing Levels of Hypoglycemia
Hypoglycemia can produce a spectrum of pro-inflammatory and pro-atherothrombotic changes. To date no studies appear to have investigated the effects of differing levels of hypoglycemia on the vasculature and pro-atherothrombotic…
- Trial name
- NCT02445781
- Testing
- Glucose clamp
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cognitive Decline
Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
The aim of this study is to investigate the modulation effects of Baduanjin (BDJ), a simple and innovative mind-body exercise, on cognitive function, resting state functional connectivity, and brain morphometry in individuals…
- Trial name
- BDJ (NCT04009382)
- Testing
- Baduanjin Exercise, Cognitive Fitness Program
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Participants
A Study to Assess the Mass Balance, Pharmacokinetics, and Metabolite Profiles of a Single Oral Dose of [14C]-INCB161734 in Healthy Male Participants
This study is conducted to assess the mass balance, pharmacokinetics, and metabolite profiles of a single oral dose of [14C]-INCB161734 in healthy male participants.
- Trial name
- NCT07814404
- Testing
- INCB161734
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Substance Use Disorder, Opioid Use Disorder, Moderate
EXHIT ENTRE Comparative Effectiveness Trial
This study is a multi-site open-label randomized comparative effectiveness trial of a 28-day formulation of extended-release buprenorphine (XR-BUP) versus treatment as usual (TAU) for hospitalized patients with a moderate or…
- Conditions
- Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- EXHITENTRE (NCT04345718)
- Testing
- Extended Release Buprenorphine, Treatment as Usual
- Where
- 6 sites in United States
- Volunteers
- 344 people
- Sponsor
- Gavin Bart
Acute Neurological Injury, Emotional Distress
Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a Neuroscience…
- Trial name
- NCT05157880
- Testing
- Recovering Together
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Massachusetts General Hospital
Crohn's Disease
Dietary Therapy and Gut Microbiome in Crohn's Disease and Ulcerative Colitis
The study is proposed as a 2-year single site, open-label clinical trial of enteral nutrition or the specific carbohydrate diet in patients with active CD or UC.
- Trial name
- NCT02412553
- Testing
- Specific carbohydrate diet, Elemental diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Pulmonary Hypertension, Interstitial Lung Disease
Aerobic Exercise in Patients With Pulmonary Hypertension
This study will determine if a rehabilitation exercise program can help people with pulmonary hypertension (PH) increase their physical activity.
- Trial name
- NCT00678821
- Testing
- Aerobic exercise
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Major Depressive Disorder
XEN1101 for Major Depressive Disorder
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a novel treatment target for mood disorders through the administration of the KCNQ-selective channel opener XEN1101 (Xenon…
- Trial name
- NCT04827901
- Testing
- XEN1101
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- James Murrough
Stigma, Activity Space
Health Outcomes by Neighborhood - Baltimore
Background: Researchers have been studying patterns of mood and drug use in specific neighborhoods. This study will look at environmental factors that may affect drug use, addiction, and treatment seeking in Baltimore…
- Conditions
- Stigma, Activity Space, Social Networks, HIV Status
- Trial name
- NCT01571752
- Where
- United States
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Diabetic Foot Osteomyelitis
A Feasibility Trial to Investigate the Safety and Between-group Effect Size of STIMULAN VG and Standard of Care (SoC) in Participants With Diabetic Foot Osteomyelitis
The purpose of this trial is to evaluate the safety and between-group effect size of STIMULAN VG compared to SoC treatment in patients with diabetic foot osteomyelitis (DFO).
- Trial name
- BLADE-VG2 (NCT05539963)
- Testing
- STIMULAN VG, Systemic Antibiotics
- Where
- 10 sites in United States
- Volunteers
- 61 people
- Sponsor
- Biocomposites Ltd
Prurigo Nodularis
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN)
The purpose of this study is to evaluate the safety and tolerability of Ruxolitinib cream in participants with Prurigo Nodularis (PN).
- Trial name
- TRuE-PN2 (NCT05764161)
- Testing
- Ruxolitinib Cream, Vehicle Cream
- Where
- 76 sites in United States, Australia and 11 more
- Volunteers
- 190 people
- Sponsor
- Incyte Corporation
Autism Spectrum Disorder
Cannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)
This trial aims to study the efficacy and safety of cannabidivarin (CBDV) in children with ASD.
- Trial name
- NCT03202303
- Testing
- Cannabidivarin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Recurrent Hodgkin Lymphoma, Refractory Hodgkin Lymphoma
Ibrutinib and Brentuximab Vedotin in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
This phase II trial studies how well ibrutinib and brentuximab vedotin work in treating patients with Hodgkin lymphoma that has returned (relapsed) or does not respond to treatment (refractory).
- Trial name
- NCT02744612
- Testing
- Brentuximab Vedotin, Ibrutinib
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- City of Hope Medical Center
Alzheimer's Disease, Mild Cognitive Impairment
Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3
Investigate the long-term impact of amount and duration of Tailored Lighting Intervention (TLI) obtained from Aims 1 and 2 on sleep, cognition, circadian marker, mood, and behavior in AD/ADRD patients.
- Trial name
- NCT06595030
- Testing
- Active Lighting Intervention, Control Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus, Type 2
Prospective Studies of the Natural History of Diabetes Mellitus and Its Complications in the Gila River Indian Community
This project is a continuation of an extensive longitudinal population-based epidemiological investigation of the etiology and determinants of type 2 diabetes (and its complications) and formerly arthritis.
- Trial name
- NCT00339482
- Where
- United States
- Volunteers
- 12,647 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes Mellitus
GLP-1 and Hypoglycemia
Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels.
- Trial name
- NCT01858896
- Testing
- Glucagon-Like Peptide- 1 (GLP-1) infusion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Muscle Soreness
A Study to Evaluate the Analgesic Properties of Topically Applied Menthol in Marathon Participants
The purpose of the research study is to better understand the factors that impact pain experience in adult (18+ years) marathon runners participating in the 2026 Chicago Marathon and to better understand if topically applied…
- Trial name
- NCT07873242
- Testing
- Observational, Non-Interventional Study
- Where
- United States
- Volunteers
- 687 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
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