Clinical trials: in Tanzania
Parenting Self Efficacy, Postpartum Depression
Essential Coaching for Every Mother in Tanzania
The purpose of this study is to evaluate a text message intervention called Essential Coaching for Every Mother in Tanzania to improve mothers' access to essential newborn care information during the immediate six-week postnatal…
- Conditions
- Parenting Self Efficacy, Postpartum Depression, Postpartum Anxiety, Breastfeeding Self-Efficacy
- Trial name
- ECEMTZ (NCT05362305)
- Testing
- Essential Coaching for Every Mother
- Where
- Tanzania
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Tuberculosis, MDR
Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients
The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB) during 96 weeks of follow-up among…
- Trial name
- PHOENIx MDR-TB (NCT03568383)
- Testing
- Delamanid (DLM), Isoniazid (INH), Pyridoxine (vitamin B6)
- Where
- 31 sites in Botswana, Brazil and 11 more
- Volunteers
- 5,832 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis (TB)
A Study to Evaluate the Efficacy, Safety and Immunogenicity of MTBVAC in Adolescents and Adults Living in a TB Endemic Region.
A Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety and immunogenicity of a candidate tuberculosis (TB) vaccine, MTBVAC, against TB disease in adolescents and adults aged 14-45 years…
- Trial name
- NCT06272812
- Testing
- MTBVAC
- Where
- 16 sites in Kenya, South Africa and 1 more
- Volunteers
- 5,531 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Health Knowledge, Attitudes, Practice, Training
Evaluating the Effects of Reproductive Health Training on Provider Behavior
The goal of this randomized, controlled, single blinded trial is to evaluate the medium to long-term effects of an Afrocentric sexual health curriculum on health professional students' knowledge, attitudes, and clinical skills in…
- Trial name
- THP-2 (NCT06428058)
- Testing
- Comprehensive sexual health curriculum
- Where
- Tanzania
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Schistosomiasis, Health Education
Health Education Model Led by Community Health Volunteers.
The goal of this intervention study is to investigate the level of knowledge, attitudes, and behaviors of students on schistosomiasis in Pemba Island.
- Trial name
- NCT06312462
- Testing
- health education
- Where
- Tanzania
- Volunteers
- 978 people, healthy volunteers welcome
- Sponsor
- Pemba Ministry of Health Zanzibar
Rift Valley Fever, Hemorrhagic Fevers, Viral
RVF and Other Emerging Infectious Diseases in East and Central Africa
Rift Valley fever (RVF), a disease transmitted from livestock (cattle, sheep, goats, camels) to humans more commonly occurs in the East and Central Africa (ECA) regions where more than 15 major epidemics affecting more than one…
- Trial name
- NCT05139524
- Testing
- Evidence of past or recent RVF exposure
- Where
- 10 sites in Democratic Republic of the Congo, Kenya and 2 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Washington State University
Anemia
Multiple Micronutrient Supplementation With Digital Layering Among Adolescents in Tanzania
This study is a three-arm, individually randomized controlled trial evaluating the impact of digitally delivered nutrition education, layered onto multiple micronutrient supplementation (MMS), on anemia and related health…
- Trial name
- MMSDigitalTZ (NCT07493772)
- Testing
- Behavioral: SMS Intervention (Intervention Arm I), Behavioral: In Person Digital Arm (Intervention Arm II)
- Where
- Tanzania
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Sexual and Reproductive Health, Disability
Evaluation of a Disability-Focused Sexual and Reproductive Health Curriculum for Health Students in Tanzania
This randomized controlled trial will evaluate the efficacy of a three-day sexual and reproductive health curriculum focused on persons with disabilities and tailored to the Tanzanian context.
- Conditions
- Sexual and Reproductive Health, Disability, Health Knowledge, Attitudes, Practice, Health Education
- Trial name
- NCT07772778
- Testing
- Disability-Focused Sexual and Reproductive Health Curriculum
- Where
- Tanzania
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sexual and Reproductive Health, Health Knowledge, Attitudes, Practice
Evaluating the Effects of Reproductive Health Training on Provider Behavior - Aim 3
This study will evaluate the real-world effectiveness of a four-day Afrocentric sexual and reproductive health curriculum for health professional students in Tanzania.
- Conditions
- Sexual and Reproductive Health, Health Knowledge, Attitudes, Practice, Provider Behavior, Health Education
- Trial name
- THP-2 Aim 3 (NCT07770438)
- Testing
- Afrocentric Sexual and Reproductive Health Curriculum
- Where
- 3 sites in Tanzania
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
HIV Prevention
Private-sector Access to Testing for Health Sustainability
New and innovative strategies are urgently needed to increase the uptake of HIV prevention and sexual and reproductive health services among adolescent girls and young women (AGYW) in sub-Saharan Africa.
- Trial name
- PATHS (NCT06820697)
- Testing
- Low HIVST kit subsidy, High HIVST kit subsidy
- Where
- Tanzania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Parents
Father-Inclusive Parenting Intervention in Mwanza, Tanzania
This cluster-randomized controlled trial aims to evaluate the impact of a couples-based parenting program, "Familia Bora," on mothers' and fathers' parenting, couples' relationships, gender, and early child development in the…
- Trial name
- NCT07025447
- Testing
- Familia Bora
- Where
- 2 sites in United States, Tanzania
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- Emory University
Human Papilloma Virus
A Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls
Cervical cancer is the most common cancer in women aged 15-44 years in East Africa, and mortality rates are very high. HPV vaccines are most effective if given to girls who have not yet acquired HPV infection.
- Trial name
- DoRIS (NCT02834637)
- Testing
- bivalent HPV vaccine, nonavalent HPV vaccine
- Where
- Tanzania
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HPV Infection, Vaccine Preventable Disease
Adding Male Single Dose HPV Vaccination to Female HPV Vaccination in Tanzania
Add-Vacc is an unblinded cluster-randomised trial (CRT) with two arms: (i) the national HPV vaccination programme (girls aged ~14 years, control arm) and (ii) the national programme plus single-dose male HPV vaccination given to…
- Trial name
- Add-Vacc (NCT04953130)
- Testing
- Gardasil® HPV vaccine
- Where
- Tanzania
- Volunteers
- 10,400 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
AmbassADDOrs for Health Study
The goal of the study is to evaluate Malkia Klabu ("Queen Club") in Tanzania, a loyalty program intervention that creates adolescent girls and young women (AGYW)-friendly drug shops where AGYW can access HIV prevention services…
- Trial name
- ADDO (NCT05357144)
- Testing
- Loyalty card program at drug shops & supply of HIVST and SRH products, Comparison drug shops
- Where
- 2 sites in Tanzania
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cervical Cancer
Supporting the National Expansion of HPV-based Cervical Cancer Screening in Tanzania Among Women Living With HIV
Cervical cancer is caused by persistent infections with one of ~13 carcinogenic human papillomavirus (HPV) types and causes substantial morbidity and mortality worldwide.
- Trial name
- NCT06402383
- Testing
- Vaccination Provision, Vaccination Provision 2
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Dr. Karen Yeates
Perinatal Death, Hypertension, Pregnancy-Induced
Pregnancy in the Context of Urbanicity and Climate Change. The Overall Aim of the Project is to Co-create, Implement, and Test New Clinical Guidelines in Order to Improve the Quality of Care in Antenatal Clinics in the Context of Urbanisation and Climate Change in Dar es Salaam, Tanzania.
Tanzania's population is growing quickly, and Dar es Salaam is one of the fastest-growing cities in the world. At the same time, the city is increasingly affected by very hot weather, flooding, and air pollution.
- Conditions
- Perinatal Death, Hypertension, Pregnancy-Induced, Abortion, Spontaneous, Stillbirth
- Trial name
- NCT07751432
- Testing
- CC-ANC intervention group.
- Where
- Tanzania
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Esophageal Squamous Cell Carcinoma, Esophageal Squamous Dysplasia
Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma
In the current protocol, we propose a study to evaluate a novel, combined esophageal sponge-methylation biomarker strategy for the early detection of esophageal squamous cell carcinoma (ESCC) as well as its precursor, esophageal…
- Trial name
- NCT05028725
- Testing
- EsophaCap Sponge, Chromoendoscopy, EsoCAN assay
- Where
- 2 sites in Tanzania
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension
Engaging Religious Leaders to Reduce Blood Pressures in Tanzanian Communities
The investigators hypothesize that communities in which religious leaders are provided with education about blood pressure and how to measure blood pressure will have lower overall average blood pressures than communities in…
- Trial name
- NCT05416372
- Testing
- Religious Engagement in Health Intervention
- Where
- Tanzania
- Volunteers
- 16,046 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
HIV, PrEP
Pharmacy-based Provision of Pre-exposure Prophylaxis (PrEP) for Adolescent Girls and Young Women in Tanzania
Implementation study comparing standard pre-exposure prophylaxis (PrEP) services to four models of pharmacy-based PrEP access for young women aged 18-24 (YW) in Tanzania.
- Trial name
- MWOTAJI (NCT07687888)
- Testing
- Pharmacy-based PrEP services, Distribution of HIV self-test kits
- Where
- Tanzania
- Volunteers
- 2,818 people, healthy volunteers welcome
- Sponsor
- Mzumbe University - Centre of Excellence in Health Monitoring and Evaluation