Clinical trials: open to volunteers, in Singapore
Arteriovenous Graft Stenosis
Scoring Balloon and High Pressure Balloon in the Treatment of Arteriovenous Graft Stenosis
This is a multicenter, prospective, randomized controlled clinical study. Patients with hemodialysis arteriovenous graft fistula stenosis will be recruited to explore whether the scoring balloon is superior to the high pressure…
- Trial name
- DKTAVG (NCT06503692)
- Testing
- DKutting PTA Scoring Balloon Dilatation Catheter, Peripheral Balloon Catheter
- Where
- 7 sites in China, Singapore
- Volunteers
- 140 people
- Sponsor
- DK Medical Technology (Suzhou) Co., Ltd.
Haematological Cancer, Healthy
Pulsed Electromagnetic Fields in Preventing Physical Deconditioning in Patients Undergoing Prolonged Hospitalization
The goal of this clinical trial is to examine if pulsed electromagnetic fields (PEMF) can prevent or decrease physical deconditioning associated with prolonged hospitalisation and immobility of haematology patients.
- Trial name
- PEMF (NCT06744764)
- Testing
- PEMF (1mT), PEMF (0mT)
- Where
- 2 sites in Singapore
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Nasopharyngeal Carcinoma
ChemoRT With and Without Dental Stent for Taste Protection in NPC Patients
Primary objective: Evaluate and compare incidence of acute and long-term taste dysfunction in chemoradiation plus dental stent group vs.
- Trial name
- NCT06733948
- Testing
- Dental stent, No dental stent
- Where
- 2 sites in Singapore
- Volunteers
- 50 people
- Sponsor
- National University Hospital, Singapore
Glaucoma
Nicotinamide Supplementation in Glaucoma
The goal of this clinical trial is to learn if nicotinamide (NAM, vitamin B3) supplementation can delay glaucoma progression 30% above that achieved with conventional glaucoma treatment using topical medication.
- Trial name
- TAMING (NCT06731582)
- Testing
- Nicotinamide Tablet
- Where
- 2 sites in Singapore
- Volunteers
- 520 people
- Sponsor
- Singapore Eye Research Institute
Head and Neck Cancers, Acute Radiation Dermatitis
StrataXRT vs Standard Clinical Practice for the Prevention of Acute Dermatitis in Head and Neck Cancers Patients
This is a phase IV, prospective, double-blind, randomized controlled trial with 2 study arms. The study population will be patients receiving chemoradiation for head and neck carcinomas, the majority of whom will be outpatients…
- Trial name
- NCT03394417
- Testing
- StrataXRT
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Systemic Lupus Erythematosus
Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region
Lupus Low Disease Activity State (LLDAS) study is an international, multi-centre prospective study, developed by the Asia Pacific Lupus Collaboration (APLC) to investigate whether the attainment of LLDAS is associated with…
- Trial name
- APLCLLDAS (NCT03138941)
- Where
- 20 sites in Australia, China and 9 more
- Volunteers
- 5,000 people
- Sponsor
- Monash University
Bleeding Ugi
PillSense for Suspected Upper Gastrointestinal Bleeding
This study aims to evaluate the efficacy and safety of a novel blood sensing capsule (PillSense), to help emergency doctors better evaluate if patients have active upper digestive tract bleeding, to determine if they can be…
- Trial name
- BLEED (NCT06500468)
- Testing
- PillSense System
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Tan Tock Seng Hospital
Heart Failure, Cardiometabolic Syndrome
Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body
Positron emission tomography with 18F fluorodeoxyglucose (FDG) is the conventional imaging technique to provide information regarding tissue glucose uptake and has been highly clinically successful.
- Conditions
- Heart Failure, Cardiometabolic Syndrome, Cancer Diagnosis, Cardiovascular Diseases
- Trial name
- POLARIC-13 (NCT06645691)
- Testing
- Hyperpolarized 13C-pyruvate
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Myopia, Myopia Progression
Evaluation of Performance of MiYOSMART Photochromic and Clear Spectacle Lenses in Myopic Children
This clinical study aims to evaluate the non-inferiority of the photochromic DIMS spectacles lenses performance (PDIMS) compared to clear DIMS spectacles lenses (DIMS) in myopia management.
- Trial name
- PDIMS (NCT06717035)
- Testing
- EYE001
- Where
- Singapore
- Volunteers
- 202 people
- Sponsor
- Singapore National Eye Centre
Ulcerative Colitis (UC)
AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis
This international multicentre prospective study aims to develop a new simple score using enhanced endoscopic techniques which focus on the vascular features of the colon and reliably distinguish between a quiescent and a mild…
- Trial name
- MONET (NCT06709209)
- Testing
- Colonoscopy after bowel cleansing, Intestinal biopsies, blood sampling
- Where
- 11 sites in Belgium, Germany and 4 more
- Volunteers
- 300 people
- Sponsor
- University College Cork
Glioma, Malignant
FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma
The goal of this clinical trial is to evaluate the performance characteristics of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET in differentiating pseudoprogression from tumour progression in patients with equivocal conventional…
- Trial name
- FET PET in HGG (NCT06172595)
- Testing
- FET PET
- Where
- 2 sites in Singapore
- Volunteers
- 22 people
- Sponsor
- Singapore General Hospital
Gestational Diabetes Mellitus (GDM), Glucose Intolerance During Pregnancy
Early Screening for Gestational Diabetes Mellitus in a Low Risk Population
This new feasibility pilot study aims to refine the design and protocols for a larger trial that will investigate the potential benefits of early oral glucose tolerance test (OGTT) screening in a population traditionally defined…
- Trial name
- EaGeR (NCT06704035)
- Testing
- Early OGTT Results Revealed
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Cancer, Malignancy
Allogeneic NKG2DL-targeting CAR γδ T Cells (CTM-N2D) in Advanced Cancers (ANGELICA)
CAR-T is a pioneering cancer treatment which has found success in some cancers. This treatment is made first by taking blood cells from the patient.
- Conditions
- Cancer, Malignancy, Refractory Cancer, Relapsed Cancer
- Trial name
- ANGELICA (NCT05302037)
- Testing
- Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells (CTM-N2D)
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- CytoMed Therapeutics Pte Ltd
Myocardial Infarction, Acute
UNdeRstAnding Novel Variants in AcutE MyocardiaL Infarction in Young Adults
Cardiovascular disease (CVD) imposes significant mortality and morbidity worldwide. However, large gaps in our knowledge of CVD still exist.
- Trial name
- UNRAVEL (NCT06698341)
- Testing
- Blood Draw
- Where
- Singapore
- Volunteers
- 1,200 people
- Sponsor
- National Heart Centre Singapore
Disorder, Heart
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on…
- Conditions
- Disorder, Heart, Postoperative, Cardiac Surgery
- Trial name
- TRICS-IV (NCT04754022)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 54 sites in United States, Australia and 14 more
- Volunteers
- 1,440 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus Type 2
App-based Motivational Interviewing and Artificial Intelligence in Diabetes Management
There is an urgent need for better control and prevention of complications in type 2 diabetes mellitus (T2DM). Behavioural change is critical, and while literature suggests that motivational interviewing (MI) may be effective in…
- Trial name
- EmpowerPlus (NCT06214520)
- Testing
- App-based Motivational Interviewing & Human health coaching, Empower+ App & Smartwatch wearable tracker
- Where
- 3 sites in Singapore
- Volunteers
- 525 people
- Sponsor
- Singapore General Hospital
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Outcomes of a Novel Technique Minimal Scar Mastectomy
Nipple sparing mastectomy is oncologically safe and has a good cosmetic outcome. However, nipple sparing mastectomy was conventionally performed with reconstruction.
- Trial name
- NCT06676761
- Testing
- nipple sparing mastectomy without reconstruction
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- KK Women's and Children's Hospital
Spontaneous Coronary Artery Dissection
SCAD : a Registry of Spontaneous Coronary Artery Dissection
Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors.
- Trial name
- SCAD (NCT06601270)
- Testing
- There are no interventions as the study is purely observational.
- Where
- 73 sites in Argentina, Austria and 22 more
- Volunteers
- 1,500 people
- Sponsor
- European Society of Cardiology
Cardiovascular Diseases, Metabolic Syndrome
Redirecting Immune, Lipid and Metabolic Drivers of Early Cardiovascular Disease: The RESET Cohort Study
Project RESET is a Singapore National Medical Research Council Large Collaborative Grant funded program that brings together a nationwide community of cardiovascular, metabolic, and digital health researchers, as well as…
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease
- Trial name
- RESET (NCT06211868)
- Testing
- Digital wearable and AI-human symbiotic lifestyle intervention
- Where
- Singapore
- Volunteers
- 3,000 people
- Sponsor
- National University Hospital, Singapore
Nasopharyngeal Carcinoma
tReatment Individualisation By EBV stratificatiON in Nasopharyngeal Carcinoma: an Umbrella Platform Study (RIBBON-Umbrella)
This is a prospective platform study that will investigate the outcomes of patients with locoregionally-advanced nasopharyngeal carcinoma (LA-NPC) or recurrent-metastatic nasopharyngeal carcinoma (RM-NPC) who are assigned to…
- Trial name
- NCT05517135
- Testing
- Arm 1, Arm 2, Arm 3
- Where
- Singapore
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Centre, Singapore