Clinical trials: completed, in Portugal
Parkinson's Disease
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who…
- Trial name
- ACTIVATE (NCT05819359)
- Testing
- BIA 28-6156 10 mg, BIA 28-6156 60 mg
- Where
- 95 sites in United States, Canada and 9 more
- Volunteers
- 273 people
- Sponsor
- Bial R&D Investments, S.A.
Sjogren's Syndrome
A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)
The purpose of this study is to evaluate the efficacy and safety of nipocalimab in participants with primary Sjogren's syndrome (pSS) versus placebo.
- Trial name
- NCT04968912
- Testing
- Nipocalimab, Standard of Care Treatment
- Where
- 69 sites in United States, France and 8 more
- Volunteers
- 163 people
- Sponsor
- Janssen Research & Development, LLC
Social Media Addiction, Craving to Use Social Media
tDCS for Social Media Addiction
The goal of this clinical trial is to learn whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation, can reduce "craving" and problematic levels of social media/internet use in university…
- Conditions
- Social Media Addiction, Craving to Use Social Media, Craving, Internet Addiction
- Trial name
- tDCS4SMA (NCT07410104)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Portugal
- Volunteers
- 61 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Occupational Stress or Workplace Stress, Burnout Syndrome
tDCS for Stress and Burnout in Higher Education
The goal of this clinical trial is to evaluate if transcranial direct current stimulation (tDCS) works to reduce occupational stress and burnout in university professors.
- Conditions
- Occupational Stress or Workplace Stress, Burnout Syndrome, Burnout
- Trial name
- tDCS4HESnB (NCT07411833)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Portugal
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Spinal Muscular Atrophy (SMA)
A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy
Risdiplam works by helping the body produce more survival motor neuron (SMN) protein throughout the body. This means fewer motor neurons - nerve cells that pass impulses from nerves to muscles to cause movement - are lost, which…
- Trial name
- MANATEE (NCT05115110)
- Testing
- RO7204239, Risdiplam
- Where
- 29 sites in United States, Australia and 10 more
- Volunteers
- 97 people
- Sponsor
- Hoffmann-La Roche
Fear of Falling
Dual-Task vs. Multicomponent Exercise in Institutionalized Seniors
The aging global population faces a major public health challenge regarding the growing number of older adults in long-term care facilities.
- Trial name
- DT-Fall (NCT07427225)
- Testing
- Multicomponent Exercise Program, Dual-Task Exercise Program
- Where
- Portugal
- Volunteers
- 54 people
- Sponsor
- Instituto Politécnico de Leiria
Chronic Rhinosinusitis Without Nasal Polyps
A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
The primary purpose of the study is to evaluate the efficacy of brensocatib at 10 and 40 milligrams (mg) once daily (QD) compared with placebo in improving clinical symptoms of CRSsNP.
- Trial name
- BiRCh (NCT06013241)
- Testing
- Brensocatib, Mometasone furoate nasal spray (MFNS)
- Where
- 100 sites in United States, Argentina and 13 more
- Volunteers
- 288 people
- Sponsor
- Insmed Incorporated
Ventricular Tachyarrhythmia
Lead EvaluAtion for Defibrillation and Reliability (LEADR) / Lead Evaluation for Defibrillation and Reliability in Left Bundle Branch Area Pacing (LEADR LBBAP)
The LEADR study is designed to assess the safety and efficacy of the Next Generation ICD lead. The LEADR LBBAP study is being conducted under the existing US FDA Investigational Device Exemption (IDE) for the Next Generation ICD…
- Trial name
- NCT04863664
- Testing
- Defibrillation (RV Implant), Defibrillation (LBBAP Implant)
- Where
- 55 sites in United States, Australia and 18 more
- Volunteers
- 1,007 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Dry Needling, Technique for the Treatment of the Myofascial Trigger Points, Dry Needling Technique
Dry Needling in the Management of Myofascial Trigger Points in the Orofacial Area: A Randomized Controlled Clinical Trial
A prospective, double-blinded, randomized, controlled clinical trial was conducted, in which Dry Needling (DN), sham DN (placebo), and counselling (gold standard) were compared, with specific objectives to assess both the…
- Conditions
- Dry Needling, Technique for the Treatment of the Myofascial Trigger Points, Dry Needling Technique, Temporomandibular Disorders (TMD)
- Trial name
- NCT07913984
- Testing
- Dry Needling, Counselling
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Universidade do Porto
Psychological Distress, Well-Being, Psychological
Heart Rate Variability Biofeedback in Security Forces
This exploratory study evaluates the effectiveness of a 12-session Heart Rate Variability Biofeedback (HRV-BFB) protocol in reducing distress and burnout while promoting psychological well-being among Portuguese National…
- Conditions
- Psychological Distress, Well-Being, Psychological, Burnout
- Trial name
- GNR-HRVB (NCT07386951)
- Testing
- Heart Rate Variability Biofeedback (HRV-BFB) Training
- Where
- Portugal
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Human Immunodeficiency Virus Type 1
A Roll-over Study With Rilpivirine for Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Who Participated in Rilpivirine Pediatric Studies
The purpose of this study is to provide continued access to rilpivirine (RPV) for participants who were treated with RPV in a clinical development pediatric study with rilpivirine and who, at the time of roll-over, experience and…
- Trial name
- NCT02494986
- Testing
- Rilpivirine
- Where
- 8 sites in Portugal, South Africa and 3 more
- Volunteers
- 48 people
- Sponsor
- Janssen Sciences Ireland UC
Premalignant Conditions, Malignant Lesions
To Evaluate the Best Metric for Inspection Time During a Diagnostic and/or Surveillance Upper Gastrointestinal Endoscopy (Age ≥ 18 Years, Informed Consent), Between Total Inspection Time Versus Withdrawal Time, for the Identification of Malignant Lesions
Gastric cancer is the fifth cause of cancer-related mortality worldwide. Gastric carcinogenesis involves the progression from premalignant conditions such as atrophic gastritis and intestinal metaplasia to premalignant lesions…
- Conditions
- Premalignant Conditions, Malignant Lesions, Gastric, Esophageal
- Trial name
- NCT06696209
- Testing
- Analysis of the withdrawal time of the Upper Gastrointestinal Endoscopy, Analysis of the total time of the Upper Gastrointestinal Endoscopy, Upper gastrointestinal endoscopy: Common Practices
- Where
- Portugal
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Pulmonary Hypertension, Heart Failure
Study for Evaluation of Safety and Efficacy of PADN to Treat Combined Post- and Pre- Capillary Pulmonary Hypertension Associated With Chronic Heart Failure（PADN-CpcPH-PILOT）
The goal of this pilot study is to evaluate the safety and efficacy of pulmonary artery denervation (PADN) in Combined Post- and Pre- Capillary Pulmonary Hypertension Associated with Chronic Heart Failure.
- Trial name
- NCT05996562
- Testing
- Pulmonary Artery Denervation
- Where
- 7 sites in Georgia, Italy and 3 more
- Volunteers
- 30 people
- Sponsor
- Pulnovo Medical (Wuxi) Co., Ltd.
Esophageal Squamous Cell Carcinoma (ESCC), Gastroesophageal Junction Carcinoma (GEJC)
Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)
The purpose of this study is to assess the efficacy and safety of treatment with definitive chemoradiotherapy (dCRT) + pembrolizumab (MK-3475) compared to treatment with dCRT + placebo with respect to Event-free Survival (EFS)…
- Conditions
- Esophageal Squamous Cell Carcinoma (ESCC), Gastroesophageal Junction Carcinoma (GEJC), Esophageal Adenocarcinoma (EAC)
- Trial name
- NCT04210115
- Testing
- pembrolizumab, cisplatin, 5-FU
- Where
- 170 sites in United States, Argentina and 25 more
- Volunteers
- 703 people
- Sponsor
- Merck Sharp & Dohme LLC
Sjogren's Syndrome
A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity
Primary Objective: To evaluate the effect of dazodalibep on systemic manifestations of Sjögren's Syndrome (SS) in participants with moderate-to-severe systemic disease activity. Secondary Objectives: 1.
- Trial name
- NCT06104124
- Testing
- Dazodalibep
- Where
- 206 sites in United States, Argentina and 24 more
- Volunteers
- 651 people
- Sponsor
- Amgen
Obesity
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease.
- Trial name
- NCT06077864
- Testing
- survodutide
- Where
- 542 sites in United States, Argentina and 33 more
- Volunteers
- 5,530 people
- Sponsor
- Boehringer Ingelheim
Plaque Psoriasis
A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque Psoriasis
The goal of this clinical trial is to learn if ESK-001 works to treat moderate to severe plaque psoriasis. The main questions it aims to answer are: Does ESK-001 reduce the severity of people's psoriasis? How safe is ESK-001 in…
- Trial name
- ONWARD1 (NCT06586112)
- Testing
- Envudeucitinib, Apremilast
- Where
- 156 sites in United States, Australia and 8 more
- Volunteers
- 912 people
- Sponsor
- Alumis Inc
Dynamic Balance, Range of Motion, Articular
Using BlazePod® for Pre-Season Screening of Lower Limb Injury Risk
Preventing lower limb injuries is a key concern in sports and physical activities. Even though injury prevention programs and pre-season screening have improved recently, these injuries still happen often.
- Trial name
- NCT07505537
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Healthy People Programs
Effects of 20-week Mat-Pilates & Dual-Task Training on Strength, Balance, Cognition, and Fall Risk in Older Adults
Our aims are to evaluate the impact of 20-week combined Pilates and dual-task exercises on physical fitness, balance, cognitive function, bone density in older adults.
- Trial name
- Pilates&ST (NCT07119762)
- Testing
- Pilates sections
- Where
- Portugal
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Healthy Aging
Fractal-based Gait Training in Older Adults
The purpose of the study is to investigate the influence of walking with external visual cues on brain adaptations.
- Trial name
- NCT06507137
- Testing
- Fractal, Isochronous
- Where
- Portugal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
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