Clinical trials: open to volunteers, in Philippines
Constipation, Gastrointestinal Discomfort
Efficacy of LcS-Fermented Milk on Constipation-Related Symptoms in Filipino Adults
The primary purpose of this study is to investigate whether the consumption of a probiotic drink (with Lacticaseibacillus paracasei strain Shirota (LcS)) relieves constipation-related symptoms of Filipino adults, specifically its…
- Trial name
- NCT07083596
- Testing
- Experimental: Probiotic with LcS, Control
- Where
- Philippines
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Santo Tomas
Dengue, Severe Dengue
Therapeutics for Moderate and Severe Dengue
The purpose of this multi-site, factorial randomised, platform trial is to evaluate host-directed therapeutic agents in patients hospitalised with moderate and severe dengue virus infection.
- Conditions
- Dengue, Severe Dengue, Mosquito-Borne Diseases, Vector Borne Diseases
- Trial name
- DEN-HOST (NCT07543458)
- Testing
- Dexamethasone, N-Acetylcysteine, Standard of care
- Where
- 18 sites in Bangladesh, Brazil and 8 more
- Volunteers
- 8,800 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
DESTINY-Lung03 will investigate the safety and tolerability of trastuzumab deruxtecan in combination with Immunotherapy Agents with and without chemotherapy in patients with HER2 over-expressing non-small cell lung cancer.
- Trial name
- DL03 (NCT04686305)
- Testing
- T-DXd, Durvalumab, Cisplatin
- Where
- 91 sites in United States, Australia and 17 more
- Volunteers
- 304 people
- Sponsor
- AstraZeneca
Leptospirosis
Preventive Strategies for Early and Late Complications of Leptospirosis
The goal of this clinical trial is to learn if complement factor I (CFI) works to predict development of complications in participants with leptospirosis.
- Trial name
- NCT07127718
- Testing
- Prophylactic Plasma Transfusion, Hemoperfusion, Extracorporeal Membrane Oxygenation
- Where
- 3 sites in Philippines
- Volunteers
- 678 people
- Sponsor
- National Kidney and Transplant Institute, Philippines
Poliomyelitis
Phase IV Clinical Study of Sequential Vaccination of Sabin Strain and Wild Strain Inactivated Poliovirus Vaccine
The goal of this study is to compare the immunogenicity and safety of sIPV administered via subcutaneous and intramuscular injection routes
- Trial name
- NCT07457060
- Testing
- 2wIPV+1sIPV, 1wIPV+2sIPV, 3wIPV
- Where
- 3 sites in Philippines
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Parkinson Disease, Parkinson's Disease (PD)
Developing Immersive Gamification Technology Systems For The Rehabilitation Management Of Adults With Parkinson's Disease (Phase 1 Trial)
This clinical trial aims to develop and test a prototype immersive gamification technology system (ImGTS) among healthy volunteers and to determine its acceptability, safety, and usability in a healthy population.
- Trial name
- NCT07382401
- Testing
- VR-HMD, AR-HMD, semi-CAVE
- Where
- Philippines
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augmented eXperience E-health Laboratory
Acute Radiation Dermatitis
Bacterial Cellulose-monolaurin Hydrogel for Acute Radiation Dermatitis
Acute radiation dermatitis (ARD) is almost universally experienced by patients with cancer during or after radiation therapy. This condition potentially leads to detrimental clinical outcomes as it adversely affects adherence to…
- Trial name
- NCT05079763
- Testing
- Bacterial cellulose-monolaurin hydrogel
- Where
- Philippines
- Volunteers
- 54 people
- Sponsor
- University of the Philippines
Presbyopia
Open Label, Multi-center, Phase I Study of TECLens Quantitative Refractive Crosslinking in Presbyopia-Aged Patients.
An 'on-eye' UV delivery system for corneal crosslinking can be used safely and effectively to help free presbyopic patients from the need for reading glasses.
- Trial name
- NCT07208604
- Testing
- Quantitative refractive crosslinking
- Where
- Philippines
- Volunteers
- 25 people
- Sponsor
- TECLens, Inc.
Psoriasis, Atopic Dermatitis
Novel Skin Barrier Product Versus Petrolatum for Skin Barrier Dysfunction
The goal of this clinical trial is to learn if a novel barrier topical product works to treat barrier dysfunction in adults. It will also learn about the safety of the novel barrier topical product.
- Conditions
- Psoriasis, Atopic Dermatitis, Xerosis, Contact Dermatitis
- Trial name
- NCT07183423
- Testing
- Novel barrier repair topical product, Petrolatum
- Where
- Philippines
- Volunteers
- 26 people
- Sponsor
- Makati Medical Center
Children on Chronic Peritoneal Dialysis
Comparing Conventional Continuous Ambulatory Peritoneal Dialysis Prescription (C-CAPD) With Modified-CAPD (M-CAPD) Prescription in Children With End-stage Kidney Disease From Low-resource Settings
This study aims to compare modified CAPD (M-CAPD) and conventional CAPD (C-CAPD) in terms of delivering high-quality, goal-directed PD as well as avoiding resource wastage in prevalent ESKD patients aged 2 to ≤18 years using a…
- Trial name
- NCT07134595
- Testing
- C-CAPD Prescription, M-CAPD Prescription
- Where
- Philippines
- Volunteers
- 44 people
- Sponsor
- National University Health System, Singapore
Diarrhoea;Acute, Diarrhea Travelers
Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct
The purpose of this study is to compare a single dose of rifaximin with loperamide to the current standard approach of single dose azithromycin with loperamide for the treatment of acute watery traveler's diarrhea (TD).
- Trial name
- TrEAT_TD2 (NCT05677282)
- Testing
- Rifaximin 550 MG, Azithromycin 500 MG, Loperamide
- Where
- 4 sites in Djibouti, Honduras and 2 more
- Volunteers
- 150 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Hypertension
Prospective Observational Study On The Impact Of Nebilet In Blood Pressure Control In Hypertensive Patients (HYIMPACT)
The HYIMPACT study (IMPACT of Nebilet® in Blood Pressure Control in Patients with Hypertension) is a multinational, multicenter, observational, prospective, longitudinal real-world evidence study designed to assess the…
- Trial name
- HYIMPACT (NCT06938516)
- Where
- 49 sites in Indonesia, Malaysia and 5 more
- Volunteers
- 4,537 people
- Sponsor
- A.Menarini Asia-Pacific Holdings Pte Ltd
Coronavirus, SARS-CoV-2 Infection
Next Generation T-cell Vaccine Against Coronavirus Disease (COVID-19)
The study aims to investigate the safety and immunogenicity of one dose vs two doses of a T-cell priming next-generation vaccine against Coronavirus disease.
- Conditions
- Coronavirus, SARS-CoV-2 Infection, COVID-19
- Trial name
- NCT05633446
- Testing
- PepGNP-COVID19 (One vaccination), Water for injection (One vaccination), PepGNP-COVID19 (Two vaccinations)
- Where
- 2 sites in Philippines
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gylden Pharma Ltd
Healthy Women of Child Bearing Potential
Metabolic Availability of Methionine in Mung Beans
The goal of this study is to determine the protein quality of Philippine mung beans. The main objective of this study is to determine the metabolic availability of methionine in mung beans that the body can use.
- Trial name
- NCT06184984
- Testing
- Metabolic availability of methionine in mung beans
- Where
- Philippines
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Food and Nutrition Research Institute, Philippines
Child Malnutrition
The Impact of Community Health Workers on Child Malnutrition in the Philippines
This study will focus on a new community health worker (CHW) program called 'Flourish', which is implemented by Philippine non-governmental organization (NGO) International Care Ministries (ICM).
- Trial name
- NCT05774314
- Testing
- Community Health Worker Intervention
- Where
- 4 sites in Philippines
- Volunteers
- 7,650 people, healthy volunteers welcome
- Sponsor
- International Care Ministries, Philippines
Alzheimer Disease
Monitoring Drug Efficacy in Patients with Alzheimer's Disease
This study will explore the different factors associated with drug response to acetylcholinesterase (AChE) inhibitor (donepezil) and NMDA receptor antagonist (memantine) in patients with Alzheimer's Disease.
- Trial name
- MEMORI-AD (NCT05801380)
- Testing
- AChE inhibitor monotherapy, AChE inhibitor and NMDA receptor antagonist combination therapy
- Where
- Philippines
- Volunteers
- 60 people
- Sponsor
- University of the Philippines
Systemic Lupus Erythematosus
Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region
Lupus Low Disease Activity State (LLDAS) study is an international, multi-centre prospective study, developed by the Asia Pacific Lupus Collaboration (APLC) to investigate whether the attainment of LLDAS is associated with…
- Trial name
- APLCLLDAS (NCT03138941)
- Where
- 20 sites in Australia, China and 9 more
- Volunteers
- 5,000 people
- Sponsor
- Monash University
Stunted Growth
Amino Acid Supplementation in Children with Stunting
The goal of this intervention study is to determine the effects of indispensable amino acid (IAA) supplementation on children of either sex, aged 18 to 36 months.
- Trial name
- NCT06676215
- Testing
- IAA mix supplement, Complementary food comprised of rice and legumes
- Where
- Philippines
- Volunteers
- 60 people
- Sponsor
- Food and Nutrition Research Institute, Philippines
Rare Malignant Neoplasm
Marker Assisted Selective ThErapy in Rare Cancers: Knowledge Database Establishing registrY Asia
This is a registry study that aims to collect patients' data with advanced-stage rare cancer in Asia-Pacific region. Data includes clinical information, details of treatment, prognosis, pathological diagnosis and genetic…
- Trial name
- MASTERKEY ASIA (NCT05217407)
- Testing
- Genomic sequence
- Where
- 18 sites in Japan, Malaysia and 5 more
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Center, Japan
Cardiovascular Diseases, Risk Factor, Cardiovascular
Prospective Urban Rural Epidemiology Study
To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g.
- Conditions
- Cardiovascular Diseases, Risk Factor, Cardiovascular, Health Behavior, Environmental Exposure
- Trial name
- PURE (NCT03225586)
- Where
- 34 sites in Argentina, Bangladesh and 23 more
- Volunteers
- 200,000 people
- Sponsor
- Population Health Research Institute