Clinical trials: open to volunteers, in Norway
Hereditary Pancreatic Cancer
The PREPAIRD Study: Personalized Surveillance for Early Detection of Pancreatic Cancer in High Risk Individuals
The objective of this national and multidisciplinary project is to establish and evaluate a personalized surveillance program (SP) for early diagnosis of pancreatic cancer (PC) and its precursors in individuals with a hereditary…
- Trial name
- PREPAIRD (NCT05740111)
- Testing
- Annual surveillance
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Metastatic Colorectal Cancer
Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer
The purpose of the study is to investigate the effect and side effects of personalized cancer treatment in patients with metastatic colorectal cancer (bowel cancer).
- Trial name
- EVIDENT (NCT05725200)
- Testing
- Alectinib, Cetuximab, Crizotinib
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Perineum; Wound, Postoperative Complications
Reconstruction After Abdominoperineal Resection With Robot-assisted Harvest of VRAM Flap
Non-randomized study of robot-assisted perineal reconstruction with rectus abdominis muscle flap in patients operated with abdominoperineal resection for irradiated locally advanced rectal or anal cancer.
- Conditions
- Perineum; Wound, Postoperative Complications, Rectal Neoplasms, Rectus Abdominis Hernia
- Trial name
- NCT05689775
- Testing
- Reconstruction with robot-assisted rectus abdominis muscle flap
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Obsessive-Compulsive Disorder, Social Anxiety Disorder
Neurobiological Markers of Treatment Response for Anxiety and OCD
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided.
- Conditions
- Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05663489
- Testing
- Bergen 4-Day Treatment (B4DT)
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Cervix Cancer
Plan of the Day Radiotherapy
The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.
- Trial name
- NCT05634681
- Testing
- Plan of the day, Standard plan
- Where
- Norway
- Volunteers
- 190 people
- Sponsor
- Oslo University Hospital
Descemet Stripping Automated Endothelial Keratoplasty (DSAEK), Descemet Membrane Endothelial Keratoplasty (DMEK)
DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)
The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients…
- Trial name
- DMEC (NCT05072262)
- Testing
- Nepafenac Ophthalmic, Dexamethasone Ophthalmic
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Glaucoma
NorMIGS - a Study of Micro-invasive Glaucoma Surgery
NorMIGS is a non-randomized clinical study of intraocular pressure lowering effect and complications after Preserflo microshunt implantation versus other types of glaucoma surgery.
- Trial name
- NorMIGS (NCT05340647)
- Testing
- Preserflo microshunt, Trabeculectomy, Other MIGS
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Substance Abuse, Dental Caries
Drug-free Without Toothache. A Study of Free Dental Treatment as a Part of Substance Abuse Treatment
Objectives: The main objective of the study is to investigate 1. How many patients will attend and complete dental care if they are offered it for free during the stay at "The department of substance abuse treatment, University…
- Trial name
- RUST (NCT05606562)
- Testing
- Dental care
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Proximal Humerus Fracture, 2 Part Fracture
Two- Part Proximal Humerus - Conservative vs Operative
The proximal humerus fracture (PHFs) is the third most common fracture type in the elderly, and represents 5% of the overall fractures. The incidence is increasing.
- Trial name
- NCT04106674
- Testing
- Open reduction internal stabilisation (ORIF)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Breast Cancer, Chronic Fatigue Syndrome
Monitoring of Chronic Conditions in Breast Cancer
REBECCA-1 is an observational study. Clinical research is undergoing a revolutionary change. The use of electronic patient records (EHR), digital registers, smartphones etc will create "real-world data" (RWD) that provides great…
- Trial name
- REBECCA-1 (NCT05587777)
- Where
- Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Recurrent Rectal Cancer
Induction Chemotherapy for Locally Recurrent Rectal Cancer
This is a multicentre, open-label, parallel arms, phase IIII study that randomises patients with locally recurrent rectal cancer in a 1:1 ratio to receive either induction chemotherapy followed by neoadjuvant chemoradiotherapy…
- Trial name
- PelvEx II (NCT04389086)
- Testing
- Combination drug, Chemoradiotherapy, Surgery locally recurrent rectal cancer
- Where
- 14 sites in Belgium, Netherlands and 3 more
- Volunteers
- 364 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Inflammatory Joint Diseases
The Norwegian Antirheumatic Drug Register
NOR-DMARD is a register-based longitudinal observational study of which the main objectives are to study the effectiveness of treatment of inflammatory joint diseases with biological disease modifying anti-rheumatic drugs…
- Trial name
- NOR-DMARD (NCT01581294)
- Where
- 6 sites in Norway
- Volunteers
- 15,000 people
- Sponsor
- Diakonhjemmet Hospital
Exercise Induced Laryngeal Obstruction (EILO)
HelpILO - RCT on EILO Treatment
Exercise induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by continuous visualization…
- Trial name
- NCT04620343
- Testing
- A: Breathing advice with bio-feedback, B: Breathing advice with bio-feedback, Inspiratory muscle training (IMT), C: Breathing advice with bio-feedback, Speech Therapy
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Haukeland University Hospital
Testicular Germ Cell Cancer, Seminoma
MicroRNA as Markers in Testicular Cancer
The main objective of this study is establish the performance of miR371 in management of testicular cancer
- Conditions
- Testicular Germ Cell Cancer, Seminoma, Non-Seminoma Testicular Cancer, Stage I Testicular Cancer
- Trial name
- NCT04914026
- Testing
- Biomarker analysis
- Where
- 6 sites in Norway, Sweden
- Volunteers
- 350 people
- Sponsor
- Haukeland University Hospital
Geriatric Disorder, Depression
Quality Register for Geriatric Psychiatry
QualGeP (KVALAP) is a quality register in Viken Research network for Geriatric Psychiatry. The objectives of the register are to enhance our knowledge of old persons with severe psychiatric disorders, and to secure an optimal…
- Trial name
- KVALAP (NCT01415310)
- Where
- Norway
- Volunteers
- 19,000 people
- Sponsor
- Geir Selbaek
Left Bundle-Branch Block
Prediction of Outcome by Echocardiography in Left Bundle Branch Block
Patients with left bundle branch block have an increased risk for the development of heart-failure and death. However, risk factors for unfavorable outcomes are still poorly defined.
- Trial name
- EchoLBBB (NCT04293471)
- Where
- Norway
- Volunteers
- 2,000 people
- Sponsor
- University Hospital of North Norway
Prostatic Neoplasms
Surgery Versus Radiotherapy for Locally Advanced Prostate Cancer
This prospective, open randomized phase III surgical trial seeks to study whether radical prostatectomy (with or without the combination of external radiation) improves prostate-cancer specific survival in comparison with primary…
- Trial name
- SPCG-15 (NCT02102477)
- Testing
- Prostatectomy/Surgery, Radiotherapy with adjuvant androgen deprivation therapy
- Where
- 30 sites in Denmark, Finland and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Olof Akre
Warm Antibody Autoimmune Hemolytic Anemia
A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia
The primary objective of this study is: To evaluate the long-term safety of fostamatinib in subjects with warm antibody autoimmune hemolytic anemia (wAIHA).
- Trial name
- NCT04138927
- Testing
- Fostamatinib disodium
- Where
- 37 sites in United States, Australia and 16 more
- Volunteers
- 90 people
- Sponsor
- Rigel Pharmaceuticals
Stroke, Acute, Dementia
The Immune Response to Stroke
Some patients develop cognitive decline after a stroke, but we don't always understand the mechanisms. It has been proposed that a proportion of the patients develop an autoimmune immune response, and that this could potentially…
- Trial name
- NCT05277129
- Testing
- Analysis of post-stroke immune responses
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Oslo
Thyroid Nodule, Thyroid Cancer
HRQOL in Thyroid Cancer and Thyroid Tumours
Background: Most patients with thyroid cancer have a long life expectancy, and it has been assumed among health professionals that therefore the quality of life (QOL) is good.
- Conditions
- Thyroid Nodule, Thyroid Cancer, Quality of Life
- Trial name
- NCT03676348
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital