Clinical trials: open to volunteers, in Norway
Gut Microbiota Diversity and Composition, Gut Microbiota Modulation
Effects of Barley and Kefir on Gut Microbiota in Physically Active Adults
The purpose of this randomized controlled clinical trial is to investigate whether a four-week dietary intervention consisting of a daily meal with barley and kefir can influence gut microbiota diversity and composition in…
- Conditions
- Gut Microbiota Diversity and Composition, Gut Microbiota Modulation, Probiotic, Prebiotic
- Trial name
- GUTS (NCT07864779)
- Testing
- Barley, Kefir
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western Norway University of Applied Sciences
Prostate Cancer
Prostate Risk Or Radiology Assessment Non-inferiority Design, Upfront MRI or Risk Calculator in Men With Suspected Prostate Cancer
Thousands of men take a PSA test to investigate whether they have prostate cancer every year. For the vast majority, the test is normal and further investigations are not necessary.
- Trial name
- PRORAND (NCT07422597)
- Testing
- European Study of screening for prostate cancer risk calculator
- Where
- 3 sites in Norway
- Volunteers
- 1,016 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Heart Failure
Investigating Myocardial Remodelling in the Failing Human Heart
Despite improvements in therapy, heart failure is a disease with high mortality and accelerating prevalence. To improve patient care, it is necessary to better understand the features and underlying mechanisms of myocardial…
- Trial name
- RELAX (NCT05303896)
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Healthy Adult
AdHuman - Impact of Food Additives in Humans
Food additives, in particular hydrocolloids (thickening, gelling and stabilising agents), are widely used in the food supply. Concerns about carrageenan have led the food industry to replace it with alternative hydrocolloids, yet…
- Trial name
- AdHuman (NCT07879079)
- Testing
- Carrageenan baked in bread, Xanthan and guar-gum baked in bread, Gellan baked in bread
- Where
- Norway
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Siv K Bohn
Gastrointestinal Irritation, Nutrition, Healthy
Effects of Wheat Flour Milling Method on Glycemic Response and Gastrointestinal Symptoms
The goal of this clinical trial is to learn if the way wheat flour is ground - by stone milling (an older method) or roller milling (used for most flour today) - changes blood sugar levels after eating bread, in healthy adults…
- Trial name
- STONEMILL (NCT07858110)
- Testing
- Stone-milled wheat flour bread, Roller-milled wheat flour bread (sourdough)
- Where
- Norway
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Heart Failure
Deep Learning-Based Automated Pressure-Strain Loop Analysis
Noninvasive left ventricular pressure-strain loop analysis estimates myocardial work from longitudinal strain, brachial systolic blood pressure, and cardiac valve-event timing.
- Trial name
- NCT07850726
- Testing
- Sustained Isometric Handgrip Exercise, Semi-Supine Bicycle Exercise
- Where
- Norway
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Prostate Cancer Screening
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland.
- Trial name
- MUSIC-Screen (NCT06626022)
- Testing
- MRI, ExactVu
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families
Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is two to three years.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Nervous System Diseases, Spinal Cord Diseases
- Trial name
- ALS-LTMV (NCT05744310)
- Testing
- Long term mechanical ventilation support, No long term mechanical ventilation support
- Where
- 9 sites in Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Universal Behavioral Supports
Social and Emotional Learning in Norwegian Kindergarten
This project evaluates the effectiveness of the Norwegian version of Second Step Early Learning (Småsteg), a program of 28 weeks that emphasizes learning, friendship skills, and managing several strong feelings (e.g., scared…
- Trial name
- NCT06975267
- Testing
- Norwegian version of Second Step Early Learning, Free play
- Where
- Norway
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Prostate Cancer
Immediate Curative vs Conservative Treatment in Older Men With M0, High-risk Prostate Cancer
It is currently unclear if immediate curative treatment (radiotherapy or surgery) of high-risk prostate cancer without metastasis in older men (>=75 years) generates the same survival benefits as in younger patients or if the…
- Trial name
- GrandP/SPCG19 (NCT05448547)
- Testing
- Radiotherapy or surgery, initial observation, Hormone therapy
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- Sven Löffeler
Polyps Colorectal, Colonoscopy
Optical Diagnosis of Neoplasia Using Artificial Intelligence
Computer-aided diagnosis (CADx) for colonoscopy aims to enhance optical diagnosis but often underperforms when used alongside humans due to under-reliance on AI.
- Conditions
- Polyps Colorectal, Colonoscopy, Optical Biopsy, Colorectal Cancer Control and Prevention
- Trial name
- FAIR (NCT07158203)
- Testing
- CADx simultaneously, CADx delayed
- Where
- 2 sites in Norway, Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Eating Disorders in Adolescence, Body Dissatisfaction
Young Athlete Body Project - Prevention of Body Dissatisfaction and Eating Disorders Among Adolescent Athletes
Body dissatisfaction is common among adolescents and is a well-established risk factor for the development of eating disorders. Young athletes may be particularly vulnerable because they are exposed to appearance-related…
- Conditions
- Eating Disorders in Adolescence, Body Dissatisfaction, Mental Health
- Trial name
- YABP (NCT07795333)
- Testing
- Young Athlete Body Project
- Where
- 2 sites in Norway
- Volunteers
- 1,740 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Loneliness, Social Isolation in Older Adults
The ALIVE-Project: Activity, Life Satisfaction, Inclusion, Vitality, Elderly Women
Many older women live alone and may experience loneliness, reduced social participation, and declining physical health. Regular physical activity can improve health and independence, but it is not known whether exercising in a…
- Conditions
- Loneliness, Social Isolation in Older Adults, Physical Inactivity, Healthy Ageing
- Trial name
- ALIVE (NCT07789080)
- Testing
- Supervised Group Exercise in Fitness Clubs, Individual exercise
- Where
- Norway
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Percutaneous Transluminal Angioplasty, Atherosclerosis of Arteries of the Extremities, Unspecified
Skin Microcirculation in Patients With Lower Limb Atherosclerosis
The aim of this study is to explore the ability of the non-invasive device ODI-Tech® to monitor changes in microvascular blood flow in patients with lower limb ischemia undergoing the procedure percutaneous transluminal…
- Trial name
- SMILLA (NCT07312383)
- Testing
- Examination with the ODI-Tech medical device
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ODI Medical AS
Mild Cognitive Impairment, Alzheimer Disease, Late Onset
Multimodal Assesment of Alzheimer Patients
The goal of this study is to learn more about the changes in the brains of patients with cognitive impairment (MCI) and Alzheimer's Disease (AD). The main questions the study aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Late Onset, Cognitive Impairment, Dementia
- Trial name
- MultiAD (NCT06448403)
- Testing
- MRI Scanning, 64-channel EEG, Polysomnography
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Alzheimer Disease, Neurodegenerative Diseases
Memory Deterioration in Alzheimer Disease
Semantic AD
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Magnetic Resonance Imaging, Memory Impairment
- Trial name
- MemAD (NCT07118137)
- Testing
- 7T MRI, EEG, Blood samples
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Chronic Migraine
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- NCT06485336
- Testing
- Atorvastatin 40mg
- Where
- 6 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Insomnia Disorder, Circadian Rhythm Sleep Disorder
The Sleep Clinic Outcome and Practice Study
The goal of this clinical trial is to explore the outcome and practice treatment for sleep-wake disturbances in a Sleep Clinic. The main questions it aims to answer are: What is the practice (timing and duration of treatment…
- Trial name
- SUP (NCT06669507)
- Testing
- Chronotherapy, Cognitive Behavioral Therapy for Insomnia
- Where
- Norway
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Episodic Migraine
Prophylactic Treatment With Atorvastatin for Episodic Migraine.
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- EStatinMig (NCT06248671)
- Testing
- Atorvastatin 40mg, Atorvastatin 20mg
- Where
- 6 sites in Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Patient Monitoring, Wearable Devices
Continuous Vital Sign Monitoring in a Surgical Ward
Unsafe patient care remains a major contributor to global morbidity and mortality. In surgical wards, postoperative patients are typically monitored intermittently using the National Early Warning Score (NEWS-2), leaving periods…
- Conditions
- Patient Monitoring, Wearable Devices, Telemonitoring, Patient Safety
- Trial name
- NCT07690267
- Testing
- Continuous Vital Sign Monitoring (CVSM)
- Where
- Norway
- Volunteers
- 9,600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus