Clinical trials: completed, in Nepal
Domestic Violence, Mental Health
Testing Family Intervention to Address Mental Health and Domestic Violence Among Women
Domestic Violence (DV) is a major public health problem in low- and middle-income countries (LMICs) including Nepal, where women often live in extended, multigenerational households, and violence can be perpetrated by the husband…
- Trial name
- DV-MH (NCT07872228)
- Testing
- Multi-component family intervention
- Where
- Nepal
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Possible
Intracranial Hypertension, Traumatic Brain Injury
Invasive Versus Non-Invasive Intracranial Pressure-Guided Management in Neurosurgical Patients
Raised intracranial pressure (pressure inside the skull) is a serious complication for patients with brain injuries, strokes, or tumors. Managing this pressure is critical to prevent further brain damage.
- Conditions
- Intracranial Hypertension, Traumatic Brain Injury, Subarachnoid Haemorrhage (SAH), Intracerebral Haemorrhage
- Trial name
- NCT07853963
- Testing
- External Ventricular Drain (EVD) Placement and ICP Monitoring, Optic Nerve Sheath Diameter (ONSD) Ultrasonography
- Where
- Nepal
- Volunteers
- 40 people
- Sponsor
- Kathmandu Medical College and Teaching Hospital
Gender-Based Violence, Intimate Partner Violence
GBV Response Training for Health Assistant Students in Nepal
This study evaluated a six-day Gender-Based Violence (GBV) response training for PCL General Medicine (Health Assistant) students in Nepal.
- Conditions
- Gender-Based Violence, Intimate Partner Violence, Health Professions Education
- Trial name
- GBV-HA-RT (NCT07851883)
- Testing
- Six-Day GBV Response Training (WHO LIVES-based)
- Where
- Nepal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Axon Infotech Research Academy Pvt. Ltd.
Stent Related Symptoms
Comparison of Stent-Related Symptoms: Regular Double J Stent vs. Comfi J Stent
A prospective, single-blinded, randomized controlled trial conducted at a single center to compare stent related symptoms between two different stents using Ureteral Stent Symptom Questionnaire (USSQ) scores , Visual Analog Scale…
- Trial name
- COMFIJ (NCT06830902)
- Testing
- Regular Double J stent, Comfi J stent
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Bir Hospital
Knee Arthroscopy, Visualization
Intra-Articular Adrenaline Versus Tourniquet in Knee Arthroscopy: A Cohort Study
Arthroscopy has become one of the most commonly performed orthopedic surgeries in the world due to it being a minimally invasive technique. Clear visualization is crucial for both safe and efficient arthroscopic procedures.
- Conditions
- Knee Arthroscopy, Visualization, Adrenaline, Tourniquet
- Trial name
- NCT07813715
- Testing
- Tourniquet, Adrenaline
- Where
- Nepal
- Volunteers
- 169 people
- Sponsor
- Kathmandu University School of Medical Sciences
Mental Health, Non Communicable Diseases
Adapting Behavioral Interventions for Dementia to Address NCDs and Mental Health
This pilot study aims to adapt the BEhavioral Community-based COmbined Intervention for MEntal Health and Noncommunicable Diseases (BECOME) to address the unique needs of individuals with dementia or mild cognitive impairment…
- Conditions
- Mental Health, Non Communicable Diseases, Dementia
- Trial name
- BECOME-D (NCT07543341)
- Testing
- BECOME-D Intervention
- Where
- Nepal
- Volunteers
- 12 people
- Sponsor
- Possible
Knee Osteoarthritis, Osteoarthritis (OA)
Clinical Outcomes of Intraarticular Platelet-Rich Plasma Injection in Knee Osteoarthritis
This prospective single-arm interventional study was designed to assess the short-term clinical outcomes of intra-articular platelet-rich plasma (PRP) injections in patients with Kellgren-Lawrence grade II and III knee…
- Conditions
- Knee Osteoarthritis, Osteoarthritis (OA), Degenerative Joint Disease of Knee, Knee Pain
- Trial name
- NCT07828561
- Testing
- Platelet-Rich Plasma (PRP)
- Where
- Nepal
- Volunteers
- 59 people
- Sponsor
- KIST Medical and Teaching Hospital
UGI Bleed
Comparison of Risk Scores in Upper Gastrointestinal Bleeding
The goal of this prospective observational study is to compare the Glasgow-Blatchford Score (GBS), AIMS65, and pre-endoscopic Rockall Score in predicting outcomes among patients with upper gastrointestinal bleeding (UGIB).
- Trial name
- NCT07819942
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Kathmandu Medical College and Teaching Hospital
Corneal Ulcer
Village Integrated Eye Workers Trial
VIEW is a community-randomized trial designed to determine whether it is possible to prevent corneal ulcers on a large scale. The study compares the incidence of corneal ulceration between villages in which volunteers are trained…
- Trial name
- VIEW (NCT01969786)
- Testing
- Corneal ulcer prevention program
- Where
- Nepal
- Volunteers
- 223,671 people
- Sponsor
- University of California, San Francisco
Problematic Internet Use, Internet Addiction
Group Cognitive-Behavioral Intervention for Problematic Internet Use in Nepalese University Students
Problematic internet use, using the internet in ways that interfere with daily life, is a growing concern among university students in Nepal, where studies report prevalence rates between 21.5% and 35.4%.
- Trial name
- NCT07806344
- Testing
- Group Cognitive-Behavioral Intervention for Problematic Internet Use
- Where
- Nepal
- Volunteers
- 59 people
- Sponsor
- Tribhuvan University, Nepal
Acute Coronary Syndromes (ACS), Adherence
Adherence to Secondary Prevention Drugs and Influencing Factors After Acute Coronary Syndrome in Patients at a Tertiary Center in Nepal
This study aimed to assess adherence to secondary prevention medications among patients in Nepal following an Acute Coronary Syndrome (ACS) event and to identify factors affecting adherence.
- Trial name
- NCT07288502
- Testing
- My Experience of Taking Medicines (MYMEDS) questionnaire
- Where
- Nepal
- Volunteers
- 109 people
- Sponsor
- Institute of medicine, Maharagjung medical campus
Intracranial Hemorrhages, Atrial Fibrillation
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
To assess whether edoxaban (60/30 mg daily) compared to non-antithrombotic medical therapy (either no antithrombotic therapy or antiplatelet monotherapy) reduces the risk of stroke (composite of ischemic, hemorrhagic and…
- Trial name
- ENRICH-AF (NCT03950076)
- Testing
- Edoxaban, Non-anticoagulant medical therapy
- Where
- 152 sites in United States, Argentina and 13 more
- Volunteers
- 948 people
- Sponsor
- Population Health Research Institute
Mental Health
Stress Management Training for Nursing Professionals in a Tertiary Care Center in Nepal
The goal of this clinical trial is to learn if stress management programs can help alleviate existing and prevent future symptoms of stress in nursing professionals working in a tertiary care center in Nepal.
- Trial name
- NCT06438016
- Testing
- Stress Management Training
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Dhulikhel Hospital
Spinal Anesthesia
Comparison of Efficacy of 0.5% Hyperbaric Bupivacaine and 0.75%Isobaric Ropivacaine for Spinal Anaeshesia
Spinal anaesthesia is a preferred technique used for lower abdominal and lower limb surgeries as it provides faster and profound sensory and motor blockade.
- Trial name
- NCT07777055
- Testing
- spinal anesthesia
- Where
- Nepal
- Volunteers
- 64 people
- Sponsor
- Tribhuvan University, Nepal
ICU Mortality
Comparison of Simplified Acute Physiology Score (SAPS II) , Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation) APACHE II Scoring Systems for Predicting Mortality of Critically Ill Patients Admitted in a Tertiary Hospital Intensive Care Unit.
This is a descriptive analytical prospective study to compare the performance of SOFA score, SAPSII score and APACHE II score in ICU mortality prediction.
- Trial name
- SAPS II SOFA (NCT07780617)
- Where
- Nepal
- Volunteers
- 201 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Postnatal Care
Use of mHealth Intervention in Improving Utilization of Postpartum Care
Despite implementation of many activities related to maternal health, maternal mortality ratio is still unacceptably high in Nepal, 239/100,000 in live births.
- Trial name
- mHealth (NCT06409208)
- Testing
- mHealth intervention (video and reminder SMSs)
- Where
- Nepal
- Volunteers
- 300 people
- Sponsor
- Dhulikhel Hospital
Mental Disorders
Reducing Stigma Among Healthcare Providers to Improve Mental Health Services
A growing number of trials have demonstrated treatment effectiveness for people with mental illness (PWMI) by non-specialist providers, such as primary care and community health workers, in low-resource settings.
- Trial name
- RESHAPE-mh (NCT02793271)
- Testing
- RESHAPE, PRIME/mhGAP
- Where
- Nepal
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Brandon A Kohrt, MD, PhD
Health Informatics Education
Health Informatics Education Effectiveness in Nepal
This study evaluates the effectiveness of a blended Health Informatics (HI) course (HI471) on knowledge retention and technology awareness among health science students in Nepal.
- Trial name
- HI-EDU (NCT07690241)
- Testing
- Health Informatics-471 Blended Course
- Where
- Nepal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Axon Infotech Research Academy Pvt. Ltd.
Post Partum Depression
Sensing Technologies for Maternal Depression Treatment in Low-Resource Settings
In certain low- and middle- income country settings, there is a disproportionate level of untreated postpartum depression that presents both acute and long-term risks to a mother's well-being.
- Trial name
- StandStrong (NCT06253676)
- Testing
- Problem Management Plus (PM+)
- Where
- Nepal
- Volunteers
- 121 people
- Sponsor
- George Washington University
Oral Hygiene, Visually Impaired Persons
Effectiveness of Audio-Tactile Performance Technique With Sing-Along Lyrics on Oral Hygiene Instruction to Visually Impaired Individuals
The goal of this match-pair randomized study is to compare the effectiveness of the standard Audio-Tactile Performance (ATP) technique with a song-based adaptation (ATP/S) in teaching oral hygiene in visually impaired individuals…
- Trial name
- NCT07585448
- Testing
- ATP, ATP with song
- Where
- 2 sites in Nepal
- Volunteers
- 40 people
- Sponsor
- Mahidol University