Clinical trials: completed, in Nepal
Wound Closure Technique, Wound Dehiscence, Surgical
Comparison of Cosmetic Outcome and Patient Satisfaction Between Staples and Suture Technique for Wound Closure Following Upper Limb Surgeries
Surgical wound closure is an essential component of postoperative care that influences wound healing, infection rates, cosmetic appearance, and patient satisfaction.
- Trial name
- NCT07633977
- Testing
- Staples, Sutures
- Where
- Nepal
- Volunteers
- 80 people
- Sponsor
- Kathmandu University School of Medical Sciences
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Distal Radius Fracture, Brachial Plexus Block
Efficacy and Safety of Hematoma Block Versus Brachial Plexus Block for Closed Reduction of Extra-Articular Distal Radius Fracture: A Prospective Study
Distal radius fractures are one of the most common types of fractures, affecting mostly youngsters and the elderly. Safety, ease of use, affordability, and effectiveness all play a role in analgesia during reduction.
- Conditions
- Distal Radius Fracture, Brachial Plexus Block, Hematoma Block
- Trial name
- NCT07625787
- Testing
- Brachial Plexus Block, Hematoma Block
- Where
- Nepal
- Volunteers
- 90 people
- Sponsor
- Kathmandu University School of Medical Sciences
Diabetes, Gestational, Telemedicine
Development and Testing of a Mobile Health Application for Management of Gestational Diabetes
Adequate control and management of gestational diabetes mellitus (GDM) during pregnancy is critical to mitigate its short- and long-term health consequences in women and their children and may serve as a key strategy to curb the…
- Trial name
- NCT04198857
- Testing
- Develop a mobile app that supports self- management and treatment for Nepalese GDM patients
- Where
- Nepal
- Volunteers
- 214 people
- Sponsor
- Rutgers, The State University of New Jersey
Cataract, Glaucoma
Village-Integrated Eye Worker Trial II - Pilot
The vast majority of blindness is avoidable. The World Health Organization (WHO) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment.
- Conditions
- Cataract, Glaucoma, Age Related Macular Degeneration, Diabetic Retinopathy
- Trial name
- VIEW II Pilot (NCT03278587)
- Testing
- Community-based screening program, Cataract camp program, Community health worker program
- Where
- Nepal
- Volunteers
- 87,992 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fracture Femur, Fracture Tibia
Standard Versus Short Course Prophylactic Antibiotic in Femur and Tibia Shaft Fractures Managed With Intramedullary Interlocking Nail
Long-bone fractures, particularly of femur and tibia, are common following fall injury and road traffic accidents.1,2 The standard treatment is "intramedullary nailing," where a metal rod is inserted into the center of the bone…
- Conditions
- Fracture Femur, Fracture Tibia, Surgical Site Infection (SSI), Antibiotic
- Trial name
- NCT07554079
- Testing
- Short Course Antibiotics, Standard Course Antibiotics
- Where
- Nepal
- Volunteers
- 56 people
- Sponsor
- Kathmandu University School of Medical Sciences
Glaucoma
Micro vs. Standard Trabeculectomy Study
The purpose of this study is to determine the reduction in intraocular pressure and cumulative incidence of complications between the standard and micro trabeculectomy surgeries 3 months after surgery.
- Trial name
- NCT02598765
- Testing
- Standard Trabeculectomy, Microtrabeculectomy
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Newborn Morbidity, Newborn Asphyxia
Cluster Randomized Controlled Trial Applying Helping Baby Breathe in Nepal
The cluster randomized controlled trial will be conducted in the selected health facilities/birthing centers of Sarlahi district in Nepal. Further from the selected health facilities.
- Conditions
- Newborn Morbidity, Newborn Asphyxia, Delivery Preterm
- Trial name
- SaLiN (NCT06213207)
- Testing
- Simulator based training to manage asphyxia and essential newborn care using neonatalie
- Where
- Nepal
- Volunteers
- 95 people
- Sponsor
- Integrated Development Foundation Nepal
Cervical Cancer, Stigma
Effectiveness of a Cervical Cancer Stigma Reduction Intervention Program on Cancer Stigma Score and Cervical Cancer Screening Uptake in Nepal
It is an interventional study to assess the effectiveness of the cervical cancer stigma reduction intervention on cancer stigma score and cervical cancer screening uptake in Nepal
- Conditions
- Cervical Cancer, Stigma, Screening
- Trial name
- NCT05489978
- Testing
- "Cervical Cancer Stigma Reduction Intervention"
- Where
- Nepal
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Kathmandu University School of Medical Sciences
Laparoscopic Cholecystectomy, Ultrasonography
Ultrasonography vs Intraoperative Laparoscopic Cholecystectomy for Gall Stone Disease
This research is designed to correlate between intraoperative status of gallstone disease patients with their USG findings. The key question it aims to answer is: Does the ultrasonography predict laparoscopic cholecystectomy will…
- Conditions
- Laparoscopic Cholecystectomy, Ultrasonography, Difficult Surgery
- Trial name
- NCT07530874
- Testing
- laparoscopic cholecystectomy
- Where
- Nepal
- Volunteers
- 130 people
- Sponsor
- Nepal Medical College and Teaching Hospital
HIV
HIV Prevention and Care Engagement in Nepal
This intervention focuses on increasing HIV testing, HIV medication adherence and reducing intersectional stigma. Our Sweekar intervention will implement 5 months of group-based activities to address the social stigma and HIV…
- Trial name
- NCT07528573
- Testing
- Sweekar intervention
- Where
- Nepal
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Internet Addiction Prevention Among Higher Secondary School Students
Effect of TPB-Based Educational Intervention on Preventing Internet Addiction in Students
This quasi-experimental study evaluated a Theory of Planned Behavior-based educational intervention among higher secondary students in Kathmandu, Nepal.
- Trial name
- NCT07504978
- Testing
- Educational Intervention Package based on the Theory of Planned Behavior
- Where
- Nepal
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Manish Rajbanshi
Chronic Kidney Diseases, Dialysis-dependent Kidney Failure
Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease
The TRACK trial is an investigator-initiated, multicentre, prospective, randomised, quadruple-blind (participant, healthcare provider, data collector, outcomes assessor), placebo-controlled trial.
- Conditions
- Chronic Kidney Diseases, Dialysis-dependent Kidney Failure, Cardiovascular Disease
- Trial name
- TRACK (NCT03969953)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- 88 sites in Australia, Belgium and 10 more
- Volunteers
- 1,753 people
- Sponsor
- The George Institute
Undernutrition
Enhancing Milk Consumption by Vulnerable Household Members in Rural Nepal
Diet quality is generally poor in rural Nepal, especially among vulnerable household members. Consumption of milk (and other animal source foods [ASF]) could contribute to improvements in diet quality.
- Trial name
- NCT05525429
- Testing
- Nutrition Education
- Where
- Nepal
- Volunteers
- 1,873 people
- Sponsor
- Tufts University
Temporomandibular Disorders (TMD), Temporomandibular Joint Disorder
A Retrospective Randomized Controlled Study Comparing the Effectiveness of Low-level Laser Therapy and Ultrasound Therapy in Reducing Pain and Increasing Maximum Mouth Opening in Forty-six Patients With Temporomandibular Disorders
Temporomandibular disorders (TMDs) are the most common cause of non-dental orofacial pain, involving the temporomandibular joint (TMJ), masticatory muscles, or associated structures.
- Trial name
- NCT07378462
- Testing
- Low-Level Laser Therapy, Ultrasound therapy
- Where
- Nepal
- Volunteers
- 46 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Domestic Violence
Testing the Effectiveness of a Safety-promoting Intervention in Antenatal Care
Domestic violence during pregnancy can directly or indirectly cause maternal and fetal morbidity and even mortality. The investigators have validated the Abuse Assessment Screen to the Nepali context for use with a color-coded…
- Trial name
- NCT05199935
- Testing
- Video, Control
- Where
- 2 sites in Nepal
- Volunteers
- 2,230 people
- Sponsor
- Norwegian University of Science and Technology
Typhoid Fever
The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)
Typhoid and paratyphoid (enteric) fever affects more than 11 million children and adults globally each year including 7 million in South Asia.
- Trial name
- ACT-South Asia (NCT04349826)
- Testing
- Azithromycin, Cefixime
- Where
- Nepal
- Volunteers
- 2,150 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Hypertension
Female Community Health Volunteers Led Hypertension Prevention and Control in Nepal
Brief Summary Hypertension is a major public health problem in Nepal, with substantial gaps in awareness, treatment, and control, particularly in rural and semi-urban settings.
- Trial name
- NCT06163859
- Testing
- Intervention Group
- Where
- Nepal
- Volunteers
- 520 people
- Sponsor
- Kathmandu University School of Medical Sciences
Pneumonia, Childhood Pneumonia
Diagnostic Accuracy of Lung Ultrasound for Pneumonia Diagnosis in Children
Chest X-ray is historically being used as an imaging standard to aid to the diagnosis of childhood pneumonia, however, the evidence does not support it as a perfect imaging tool.
- Trial name
- LUS (NCT07331311)
- Testing
- LUS as a chest imaging tool
- Where
- Nepal
- Volunteers
- 320 people
- Sponsor
- Nagasaki University
CBD Stone
Re-use of Ambu aScope During Exploration of the Common Bile Duct for Stones in Low-Resource Settings- a Retrospective Study
Various methods confirm stone clearance during surgical exploration of bile duct, but choledochoscopy is considered the most effective. However, choledochoscopes are expensive and often unavailable in low-resource settings.
- Trial name
- NCT07285447
- Testing
- Ambu aScope for visualization of biliary tree during exploration of CBD for stone
- Where
- Nepal
- Volunteers
- 75 people
- Sponsor
- B.P. Koirala Institute of Health Sciences