Clinical trials: open to volunteers, in Latvia
Dural Defect, Cerebrospinal Fluid Leak
Immiseal™ Dural Sealant Post-Market Registry Study
This is a multicentre, prospective, open-label, single-arm, observational, post-market clinical follow-up registry study designed to observe the safety and performance of the Immiseal™ Dural Sealant System when used as an adjunct…
- Conditions
- Dural Defect, Cerebrospinal Fluid Leak, Neurosurgical Procedures
- Trial name
- NCT07651826
- Where
- Latvia
- Volunteers
- 85 people
- Sponsor
- Medprin Regenerative Medical Technologies Co., Ltd.
Neurogenic Detrusor Overactivity
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
- Trial name
- KANGUROO (NCT05491525)
- Testing
- Vibegron
- Where
- 38 sites in United States, Belgium and 14 more
- Volunteers
- 71 people
- Sponsor
- Urovant Sciences GmbH
Gingival Health, Metal Ceramic Restorations
The Effect of Fixed Dentures on Periodontal Tissues in Long-term.
The goal of this observational study is to to evaluate the periodontal condition around metal-ceramic crown. The main question to be answered is: whether the metal-ceramic crown is the cause of gum changes? The study offers to…
- Trial name
- NCT07611461
- Where
- Latvia
- Volunteers
- 75 people
- Sponsor
- Riga Stradins University
Acute Exercise, Breast Cancer Cell Lines
Tumour Cell Response to Acute Aerobic Exercise in Breast Cancer Survivors: Modulatory Effects of Exercise Type and Intensity
Cancer has emerged as a prominent cause of mortality in the 21st century, with breast cancer (BC) being the most diagnosed malignancy.
- Conditions
- Acute Exercise, Breast Cancer Cell Lines, Breast Cancer Survivors, Healthy Women
- Trial name
- TCReX (NCT07439458)
- Testing
- High intensity continuous exercise, Moderate intensity continuous exercise
- Where
- Latvia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riga Stradins University
Stroke
Home-Based Stroke Rehabilitation Using Enriched Environments (PEER-HOMEcare)
The goal of this clinical trial is to learn whether the PEERHOMEcare intervention is a feasible and acceptable methodology that may have the potential to improve recovery for adults who are recovering from stroke and receiving…
- Trial name
- PEERHOMEcare (NCT07517120)
- Testing
- Environmental Mapping Tool (using S.T.E.P.S), Daily Diary
- Where
- 3 sites in Latvia, Norway and 1 more
- Volunteers
- 45 people
- Sponsor
- Norwegian School of Sport Sciences
Dental Veneers, Resin Cements
Adhesive Cementation Materials and Techniques in Aesthetic Dentistry
AIM: To determine the most effective cementation method and resin cement material for long term success of esthetical restorations TASKS: 1.
- Conditions
- Dental Veneers, Resin Cements, Composite Restoration, Orofacial Esthetic Scale
- Trial name
- NCT07491809
- Testing
- Porcelain veneers, Direct composite
- Where
- Latvia
- Volunteers
- 60 people
- Sponsor
- Riga Stradins University
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Non-Segmental Vitiligo (NSV), Alopecia Areata
A Real World Study to Globally Assess Disease Burden in Adolescent and Adult Participants With Alopecia Areata, Vitiligo, or Hidradenitis Suppurativa
This study is to assess the burden of disease in adolescent and adult participants with moderate or severe alopecia areata (AA), non-segmental vitiligo (NSV), or moderate to severe hidradenitis suppurativa (HS) in a large global…
- Conditions
- Non-Segmental Vitiligo (NSV), Alopecia Areata, Hidradenitis Suppurativa
- Trial name
- MEASUREAAVitHS (NCT07136467)
- Where
- 116 sites in Argentina, Canada and 16 more
- Volunteers
- 2,795 people
- Sponsor
- AbbVie
Periodontal Bone Loss, Periodontitis
The Role of Granulation Tissue in Periodontal Regeneration
The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in…
- Conditions
- Periodontal Bone Loss, Periodontitis, Periodontal Disease, Periodontal Diseases
- Trial name
- NCT07254117
- Where
- Latvia
- Volunteers
- 46 people
- Sponsor
- Riga Stradins University
Coronary Artery Disease
Resorbable Magnesium Scaffolds Registry
The registry follows the ESC/EACTS guideline and further investigates the clinical performance and short-term safety of RMS (Resorbable Magnesium Scaffolds) in a real world setting within the scope of its intended use without…
- Trial name
- NCT04679740
- Testing
- Magmaris, Freesolve
- Where
- 13 sites in Australia, Germany and 5 more
- Volunteers
- 1,106 people
- Sponsor
- Biotronik AG
Tachycardia, Atrial Fibrillation
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
This registry is performed for the long-term assessment of outcome, performance and residual safety aspects of the BIOMONITOR III and possible successors in a real-life clinical set-up.
- Conditions
- Tachycardia, Atrial Fibrillation, Syncope, Bradycardia
- Trial name
- BIOSTREAM-ICM (NCT04075084)
- Where
- 31 sites in Australia, Czechia and 7 more
- Volunteers
- 1,400 people
- Sponsor
- Biotronik SE & Co. KG
Sport Injury
Smart Textile Solutions as Biofeedback Method for Injury Prevention for Latvian Football Youth League Players
Lower limb injuries are the most common in youth football leagues, accounting for 72% to 93% of all injuries. The leading prevention program in football today is the FIFA 11+ warm-up program, which reduces the risk of injury by…
- Trial name
- NCT06551454
- Testing
- Smart Textile Solution Biofeedback Method
- Where
- Latvia
- Volunteers
- 80 people
- Sponsor
- Riga Stradins University
Periodontitis, Adult, Furcation Defects
A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of Furcations
Patients diagnosed with stage III or IV periodontitis who exhibit mandibular first or second molars with Class II, Subclass A, or B buccal and/or lingual mandibular furcation defects (horizontal probing depth of ≥ 3 mm ) will be…
- Conditions
- Periodontitis, Adult, Furcation Defects, Furcation of Root of Tooth, Periodontitis Complex
- Trial name
- NCT06684769
- Testing
- Emdogain® FL, Labrida BioClean®
- Where
- Latvia
- Volunteers
- 40 people
- Sponsor
- Riga Stradins University
Diabetes Mellitus
Post-Market Clinical Follow-Up of the CT3 Series Continuous Glucose Monitoring System: A 14-Day Observational Study Assessing Accuracy, Safety, and Glucose Control in Patients With Type 1 and Type 2 Diabetes Mellitus
Post market Clinical follow-up of the CT3 Series Continuous Glucose Monitoring System: A 14-Day Observational Study Assessing Accuracy, Safety, and Glucose Control in patients with Type 1 and Type 2 Diabetes Mellitus
- Trial name
- NCT07122180
- Testing
- CT3 Series Continuous Glucose Monitoring System:
- Where
- Latvia
- Volunteers
- 72 people
- Sponsor
- MDCECRO LLC
Diabetes Mellitus Type 2
Enhancing the Efficacy and Tolerability of Metformin by add-on Polyherbal Formulation: a Gut Microbiome Study
Study population: Type 2 diabetes patients Design of the study: Randomized, two-arm, placebo-controlled, and prospective crossover cohort study.
- Trial name
- Metherb (NCT06846138)
- Testing
- Polyherbal Formulation (PHF), Metformin (Standard Treatment for Type 2 Diabetes)
- Where
- Latvia
- Volunteers
- 66 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Developmental Coordination Disorder
Influence of Sensory Stimulation on Sensory Parameters and Motor Function in Children With Developmental Coordination Disorder
The goal of this clinical trial is to evaluate whether intensive sensory stimulation therapy can improve upper limb motor skills and sensory function in children aged 12-16 years with severe symptoms of Developmental Coordination…
- Trial name
- NCT06959329
- Testing
- Active and passive physical therapy without intensified sensory stimulation, Active and passive physical therapy with intensified sensory stimulation
- Where
- 2 sites in Latvia, Poland
- Volunteers
- 80 people
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Fibrosis, Liver
The Gastric Bypass Stent System as a Treatment for Hepatic Fibrosis in Obese Patients in European Region
The Gastric Bypass Stent System is intended to be used in weight loss treatment for obesity and holds potential as a non-invasive technique for managing hepatic fibrosis.
- Trial name
- NCT06561529
- Testing
- Gastric Bypass Stent System
- Where
- 2 sites in Latvia
- Volunteers
- 10 people
- Sponsor
- MDCECRO LLC
Helicobacter Pylori Infections, Atrophic Gastritis
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality
Currently no ideal preventive modalities are available for reducing gastric-cancer caused mortality in organized population-based application.
- Conditions
- Helicobacter Pylori Infections, Atrophic Gastritis, Gastric Cancer
- Trial name
- GISTAR (NCT02047994)
- Testing
- Triple therapy
- Where
- Latvia
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Tricuspid Regurgitation
Study of Transcatheter Tricuspid Annular Repair
The purpose of the study is to evaluate the safety and performance of the MIA Minimally Invasive Annuloplasty Device in patients with chronic functional tricuspid regurgitation.
- Trial name
- STTAR (NCT03692598)
- Testing
- MIA, Minimally Invasive Annuloplasty Device - Surgical, MIA, Minimally Invasive Annuloplasty Device - Percutaneous
- Where
- 6 sites in Denmark, Hungary and 3 more
- Volunteers
- 60 people
- Sponsor
- Micro Interventional Devices
H. Pylori Infection
European Registry on the Management of Helicobacter Pylori Infection
The great diversity of regimens and treatment lines, the different efficacy of these, mostly due to the increase in bacterial antibiotic resistance and regional differences, requires a continuous critical analysis of clinical…
- Trial name
- NCT02328131
- Where
- 30 sites in Austria, Belgium and 28 more
- Volunteers
- 10,000 people
- Sponsor
- Javier P. Gisbert