Clinical trials: open to volunteers, in Ireland
Focus of Study: Tailored Implementation
PIECES - Towards Large-Scale Adaptation and Tailored Implementation of Primary Cancer Prevention Programs
The PIECES project aims to evaluate the Primary Cancer Prevention Implementation Toolkit (PCP-IT), an online implementation support toolkit that aids implementation teams in improving the implementation of primary cancer…
- Trial name
- PIECES (NCT06718322)
- Testing
- Primary Cancer Prevention Implementation Toolkit (PCP-IT)
- Where
- 11 sites in Albania, Australia and 7 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hidde van der Ploeg
Critical Illness, Respiratory Failure
Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed.
- Trial name
- PREVENTION (NCT05014581)
- Testing
- Noradrenaline
- Where
- 6 sites in France, Ireland and 1 more
- Volunteers
- 420 people
- Sponsor
- University of Turin, Italy
Respiratory Distress Syndrome, Newborn, Endotracheal Intubation
An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.
This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital.
- Conditions
- Respiratory Distress Syndrome, Newborn, Endotracheal Intubation, Neonatal Intubation Performance, Prematurity
- Trial name
- NINJA (NCT06898801)
- Testing
- Just-in-time video training
- Where
- Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Cancer
E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
The primary objective is the collection of real-world data of cancer patients treated with radiotherapy, to support radiotherapy research and to provide evidence of the role of radiation oncology in a multidisciplinary approach.
- Trial name
- E²-RADIatE (NCT03818503)
- Where
- 77 sites in Austria, Belgium and 12 more
- Volunteers
- 2,000 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Infant, Premature, Diseases, Birth, Preterm
The NEU-STIM Trial
The aim of this study is to determine the effect of repetitive tactile stimulation compared to selective stimulation on oxygenation of the infant at 5 minutes after birth.
- Trial name
- NEU-STIM (NCT05942924)
- Testing
- Repeated tactile stimulation, Selective tactile stimulation
- Where
- 43 sites in Austria, Belgium and 17 more
- Volunteers
- 3,280 people
- Sponsor
- Leiden University Medical Center
Esophageal Squamous Cell Carcinoma
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer
NEEDS is a pragmatic open-label, randomised, controlled, phase III, multicenter trial with non-inferiority design with regard to the first co-primary endpoint overall survival and superiority for the experimental intervention…
- Trial name
- NEEDS (NCT04460352)
- Testing
- Neoadjuvant radiotherapy (arm A), Carboplatin, paclitaxel, Esophagectomy
- Where
- 12 sites in Canada, Ireland and 3 more
- Volunteers
- 1,020 people
- Sponsor
- Karolinska University Hospital
Amyotrophic Lateral Sclerosis, Motor Neurone Disease
Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project
Amyotrophic Lateral Sclerosis (ALS), the most common form of Motor Neuron Disease (MND), is a neurodegenerative disease. At present there are limited treatment options for this disease which progressively affects physical…
- Trial name
- TechnicALS (NCT06820008)
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- University of Dublin, Trinity College
Cervical Instabilities Spine, Spine; Instability
SYMPHONY™ OCT System for Instabilities of the Upper Thoracic and Cervical Spine
This will be a prospective, multi-centre study at a National Tertiary Referral Centre for spinal trauma and spinal cord injuries, serving a catchment area of 5 million people.
- Trial name
- NCT06816862
- Testing
- SYMPHONY™ OCT System
- Where
- Ireland
- Volunteers
- 35 people
- Sponsor
- University College Dublin
Stress, Burnout
Burnout and Resilience in Hospital-based Nursing and Medical Personnel and Trainees
Aims to look at associations between work stress, burnout and resilience in hospital-based nurses and medical professionals in several EU countries.
- Trial name
- RESIST (NCT06818539)
- Where
- Ireland
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Spinal Muscular Atrophy (SMA)
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor…
- Trial name
- NCT04174157
- Testing
- Prospective observational registry, Zolgensma
- Where
- 99 sites in United States, Greece and 9 more
- Volunteers
- 700 people
- Sponsor
- Novartis Pharmaceuticals
Airway Complication of Anesthesia
International obServational sTudy on AiRway manaGement in operAting Room and Non-operaTing Room anaEsthesia
According to WHO, more than 230 million major surgical procedures are carried out under general anaesthesia each year worldwide.
- Trial name
- STARGATE (NCT05759299)
- Testing
- Advanced airway management
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 10,500 people
- Sponsor
- University of Turin, Italy
Rectum Neoplasm, Rectum Polyp
CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery
Cancer of the lowermost part of the intestine (the rectum) is a common disease and both this disease and its treatment can have major impact on patients.
- Conditions
- Rectum Neoplasm, Rectum Polyp, Rectal Cancer
- Trial name
- NCT05793554
- Where
- Ireland
- Volunteers
- 600 people
- Sponsor
- Mater Misericordiae University Hospital
Degenerative Cervical Myelopathy
Rehab in Mild Stable DCM: Feasibility RCT Comparing Structured Rehabilitation to Clinical Surveillance
The goal of this feasibility RCT is to establish the feasibility of undertaking a RCT investigating the effectiveness of a multi component structured rehabilitation intervention aiming at reducing physical disability in people…
- Trial name
- RehabmildDCM (NCT06781658)
- Testing
- Structured rehabilitation intervention, Clinical Surveillance
- Where
- Ireland
- Volunteers
- 24 people
- Sponsor
- Royal College of Surgeons, Ireland
HIV Infections
Pharmacokinetics of Antiretroviral Agents in HIV-infected Pregnant Women.
Due to the potential for pregnancy-induced changes in the pharmacokinetics of medication, one cannot assume that the currently licensed doses of the medication to be tested under this protocol lead to adequate exposure in an…
- Trial name
- PANNA (NCT00825929)
- Where
- 21 sites in Belgium, Germany and 5 more
- Volunteers
- 176 people
- Sponsor
- Radboud University Medical Center
Stress, Wellbeing
Impact of Aromatherapy on Wellbeing and Relaxation in Gynae Oncology Patients Post Treatment
The goal of this pilot study is to learn if aromatherapy helps to reduce stress and improve relaxation and wellbeing in gynaecological cancer patients after they have finished their treatment for cancer.
- Conditions
- Stress, Wellbeing, Relaxation
- Trial name
- NCT06590077
- Testing
- Aromatherapy
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University of Dublin, Trinity College
Breast Cancer
Testing the Effectiveness of a Work Rehabilitation Intervention for Women with Breast Cancer
Women with breast cancer make up a significant proportion of cancer survivors, with more than 43,750 women living with breast cancer in Ireland.
- Trial name
- CanWork (NCT06723899)
- Testing
- CanWork
- Where
- 2 sites in Ireland
- Volunteers
- 248 people
- Sponsor
- University of Dublin, Trinity College
Disorder of Consciousness, Paralysis
Awareness Detection and Communication in Disorders of Consciousness
STUDY OVERVIEW Brain injury can result in a loss of consciousness or awareness, to varying degrees. Some injuries are mild and cause relatively minor changes in consciousness.
- Conditions
- Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke
- Trial name
- NCT03827187
- Testing
- Motor imagery based EEG-BCI
- Where
- 18 sites in Ireland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Ulster
Solid Tumor
Feasibility of Switching Fluoropyrimidine Due to Cardiotoxicity Study
The purpose of the present study is to evaluate cardiotoxicity during re-challenge of a different modality of fluoropyrimidine (primary end-point S-1 and secondary any other fluoropyrimidine) after having perceived cardiotoxicity…
- Trial name
- CardioSwitch (NCT04260269)
- Testing
- Fluoropyrimidine
- Where
- 13 sites in Denmark, Finland and 5 more
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Chronic Musculoskeletal Pain
Community-based Exercise for Older Adults With Chronic Musculoskeletal Pain
Chronic pain management services in Ireland are severely under-resourced. There is a key opportunity for community-based exercise to address some of the needs of people early in their chronic pain journey and potentially prevent…
- Trial name
- ComEx Pain (NCT06535633)
- Testing
- Intervention arm: Exercise class
- Where
- Ireland
- Volunteers
- 72 people
- Sponsor
- University of Limerick
Psychosis
A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction
Antipsychotic drugs are used to treat a range of psychiatric disorders including schizophrenia, bipolar disorders, and psychotic depression.
- Trial name
- MetaboMicrobe (NCT06729671)
- Testing
- Bifidobacterium longum APC1472 hydroxypropylmethylcellulose (HPMC) capsule, maltodextrin
- Where
- 2 sites in Ireland
- Volunteers
- 70 people
- Sponsor
- University College Cork