Clinical trials: in Hong Kong
Essential Thrombocythemia
Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003)
This is a Phase 2b open label study of an orally administered LSD1 inhibitor, Bomedemstat (MK-3543, formerly called IMG-7289), in patients with essential thrombocythemia.
- Trial name
- NCT04254978
- Testing
- Bomedemstat
- Where
- 26 sites in United States, Australia and 5 more
- Volunteers
- 73 people
- Sponsor
- Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)
Congenital Heart Disease, Pulmonary Hypertension
Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial
Wearable health technology, particularly smartwatches, has revolutionized personal health monitoring by enabling continuous, non-invasive tracking of various physiological parameters.
- Conditions
- Congenital Heart Disease, Pulmonary Hypertension, Heart Failure, Coronary Artery Disease
- Trial name
- WATCH-X (NCT06671171)
- Testing
- Apple Watch Series 9
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Subthreshold Depression, Positive Emotions
The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health
The goal of this clinical trial is to investigate how transcranial direct current stimulation (tDCS) affects emotion functions in young adults aged 18-35 from the local community, including both male and female participants.
- Conditions
- Subthreshold Depression, Positive Emotions, Negative Emotions, Anhedonia
- Trial name
- NCT07319143
- Testing
- Transcranial Direct Current Stimulation
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Fitness Trackers, Physical Activity
Full-scale Intervention Study: Genetic Risk Communication and Wearables
Background: Communication of information about risk of type 2 diabetes (T2D) alone has not been associated with changes in habitual behaviors among individuals of European ancestry.
- Conditions
- Fitness Trackers, Physical Activity, Exercise, Genetic Predisposition to Disease
- Trial name
- NCT05524909
- Testing
- Genetic Risk Estimate, Genetic Risk Estimate + Fitbit Functions
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Localized Prostate Cancer
WATER IV Prostate Cancer
This is a multicenter, prospective, randomized clinical trial that aims to assess the safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to high-risk localized prostate cancer who are candidates for…
- Trial name
- WATER IV PCa (NCT06651632)
- Testing
- Aquablation Therapy, Radical Prostatectomy
- Where
- 37 sites in United States, Canada and 5 more
- Volunteers
- 280 people
- Sponsor
- PROCEPT BioRobotics
Chronic Stress, Trauma Exposure
Game Intervention for Resilience
The goal of this clinical trial is to learn if a game-based intervention can enhance psychological resilience and promote positive affectivity in adults who have experienced major life stress.
- Conditions
- Chronic Stress, Trauma Exposure, Resilience, Psychological, Major Life Stress
- Trial name
- NCT07235696
- Testing
- Game-based Intervention, Psychoeducation intervention
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Preference, Patient
Preferences of Vaccination for COVID-19 Among University Students and Staff: A Discrete Choice Experiment
From March 2021, COVID-19 vaccines have been made available to Hong Kong residents, first to priority groups including healthcare professionals and the elderly, and later to all adults and adolescents.
- Trial name
- NCT05150769
- Where
- Hong Kong
- Volunteers
- 3,423 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Postpolypectomy Bleeding
Timing of Resumption of Direct Oral Anticoagulants Following Polypectomy
The goal of this prospective randomized non-inferiority trial is to compare two different resumption time of Direct Oral Anticoagulants (DOACs) after colonoscopic polypectomy.
- Trial name
- NCT06482333
- Testing
- Time for resumption of DOAC
- Where
- Hong Kong
- Volunteers
- 194 people
- Sponsor
- The University of Hong Kong
Spinal Deformity
AI-Powered Scoliosis Auto-Analysis System Multicenter Development and Validations
The investigators aim to use artificial intelligence (AI) to help clinicians in diagnosing and assessing spinal deformities.
- Trial name
- NCT05146193
- Testing
- Nude back photo
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Non-Alcoholic Fatty Liver Disease, Obesity
Optimal Exercise Frequency to Reduce Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty Liver Disease
This study aims to examine the comparative effectiveness of different exercise frequencies (once-a-week vs. thrice-a-week) for reducing liver fat in centrally obese adults with non-alcoholic fatty liver disease (NAFLD), with…
- Trial name
- NCT05741957
- Testing
- Once-a-week Exercise, Thrice-a-week Exercise, Usual Care Control
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- The University of Hong Kong
Tooth Defect
Clinical Evaluation of AI-Generated Dental Crowns
This clinical research validates a fully automatic AI algorithm for dental crown design using GANs trained on University of Hong Kong 3D prosthesis data and AI-powered FEA for stress correction, overcoming CAD/CAM limitations…
- Trial name
- NCT07562607
- Testing
- Conventional CAD/CAM Dental Crowns, AI-Designed Dental Crowns
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Caregiver Burden, Depressive Symptoms
Cluster RCT of Cognitive Behavioral Therapy to Support Caregivers of Older Adults in Hong Kong
The goal of this cluster randomized controlled trial study is to compare the effectiveness of a novel psychosocial intervention based on Cognitive Behavioral Therapy, lifestyle intervention and effective communication skills in…
- Conditions
- Caregiver Burden, Depressive Symptoms, Quality of Life, Self Efficacy
- Trial name
- NCT06473012
- Testing
- Cognitive Behavioral Therapy for Caregivers of Older Adults, Control intervention for Caregivers of Older Adults
- Where
- Hong Kong
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Peritoneal Metastases
The Application of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Surface Malignancies
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel minimally invasive drug delivery system for patients with peritoneal metastases (PM).
- Trial name
- PIPAC (NCT06367270)
- Testing
- Pressured Intraperitoneal Aerosol Chemotherapy
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Smartphone Addiction, Sedentary Behaviors
High-Intensity Exercise Snacks for Reducing Mobile Phone Addiction in Adolescents
This study is a randomized controlled trial (RCT) designed to evaluate the long-term effectiveness of "Exercise Snacks" (fragmented, high-intensity bouts of exercise) in reducing mobile phone addiction among adolescents.
- Conditions
- Smartphone Addiction, Sedentary Behaviors, Adolescent Behavior
- Trial name
- ES-MPA (NCT07338058)
- Testing
- Exercise Snacks Protocol
- Where
- Hong Kong
- Volunteers
- 386 people
- Sponsor
- Jinan University Guangzhou
Diabetes Mellitus, Monogenic Diabetes
Glucokinase Activator in Monogenic Diabetes
Evaluating a novel, allosteric glucokinase activator in monogenic diabetes secondary to inactivating glucokinase mutations: a randomised, cross-over trial
- Trial name
- RESENSE (NCT06976658)
- Testing
- Dorzagliatin
- Where
- Hong Kong
- Volunteers
- 44 people
- Sponsor
- Chinese University of Hong Kong
Gum Inflammation, Periodontal Diseases
Improving Gum Health Among Older Adults Using AI Based mHealth for Personalized OHI
Background: Many older adults in Hong Kong lack thorough tooth cleaning and regular dental check-ups, which can lead to plaque-induced gum diseases and systemic health issues.
- Conditions
- Gum Inflammation, Periodontal Diseases, Oral Hygiene, Oral Health
- Trial name
- NCT07187453
- Testing
- Personalized Oral Hygiene Advice using AI assisted mHealth Tool by Non-Dental Personnel
- Where
- Hong Kong
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Disease, Electrocardiograph
DigitHeart Echo Study
Eligible patients will be interviewed by research staff to explain the trial design and rationale. Written informed consent will be obtained from patients who voluntarily agree to participate.
- Conditions
- Heart Disease, Electrocardiograph, Echocardiography
- Trial name
- DigitHeart-SHD (NCT07558109)
- Testing
- echocardiography
- Where
- Hong Kong
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Vernal Keratoconjunctivitis
3% Diquafosol Ophthalmic Solution for Active Moderate-to-Severe Vernal Keratoconjunctivitis
The aim of the study is to investigate whether patients with moderate-to-severe VKC and keratitis will benefit from the addition of Diquafosol ophthalmic solution in terms of symptoms and signs of VKC, tear film metrics, ocular…
- Trial name
- NCT06903884
- Testing
- 3% Diquafosol ophthalmic solution and 0.1% Cyclosporin A cationic ophthalmic emulsion, 0.1% Cyclosporin A cationic ophthalmic emulsion
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- The University of Hong Kong
Chronic Hepatitis B
Efficacy of VTP-300 in Chronic Hepatitis B Infection
This is an open-label study to determine the efficacy, safety, tolerability and immunogenicity of ChAdOx1-HBV and MVA-HBV, together VTP-300, in combination with low-dose nivolumab, in patients with chronic HBV who are virally…
- Trial name
- NCT05343481
- Testing
- ChAdOx1-HBV, MVA-HBV, Nivolumab
- Where
- 18 sites in Hong Kong, Taiwan and 1 more
- Volunteers
- 121 people
- Sponsor
- Barinthus Biotherapeutics
Chronic Hepatitis b
Open-Label Study of AB-729, Nucleos(t)Ide Analogue and Pegylated Interferon Alfa-2a in Subjects With Chronic Hepatitis B Infection
This is a randomized, open label, multicenter Phase 2 study investigating the safety and antiviral activity of AB-729 in combination with ongoing NA therapy and short courses of Peg-IFNα-2a in subjects with CHB.
- Trial name
- NCT04980482
- Testing
- AB-729, Peg-IFNα-2a
- Where
- 17 sites in United States, Australia and 5 more
- Volunteers
- 43 people
- Sponsor
- Arbutus Biopharma Corporation
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