Clinical trials: completed, in France
Anorexia Nervosa
Prognosis of Early-onset Anorexia Nervosa
The AM2P study aims to evaluate the long-term prognosis and quality of life of patients with early-onset anorexia nervosa, assessed 4 to 9 years after hospitalization.
- Trial name
- AM2P (NCT07311356)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Axial Spondyloarthritis, Ankylosing Spondylitis
A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Subjects With Active Axial Spondyloarthritis Including Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis
The purpose of the study is to demonstrate the long-term safety, tolerability and efficacy of bimekizumab in patients with active axial spondyloarthritis (axSpA, also known as radiographic axSpa (r-axSpA)) including ankylosing…
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, r-axSpa, Nr-axSpa
- Trial name
- BE MOVING (NCT04436640)
- Testing
- Bimekizumab
- Where
- 75 sites in United States, Belgium and 12 more
- Volunteers
- 508 people
- Sponsor
- UCB Biopharma SRL
Sjogren's Syndrome
A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)
The purpose of this study is to evaluate the efficacy and safety of nipocalimab in participants with primary Sjogren's syndrome (pSS) versus placebo.
- Trial name
- NCT04968912
- Testing
- Nipocalimab, Standard of Care Treatment
- Where
- 69 sites in United States, France and 8 more
- Volunteers
- 163 people
- Sponsor
- Janssen Research & Development, LLC
Alcohol Use, Cannabis Use
Evaluation of Purple Town
Purple Town is a media literacy-based prevention and harm reduction program that uses a mobile game, with or without accompanying facilitated workshops, to raise young people's awareness of the risks associated with alcohol and…
- Conditions
- Alcohol Use, Cannabis Use, Health Literacy
- Trial name
- Purple Town (NCT07919639)
- Testing
- Purple Town prevention program, Purple town mobile game
- Where
- France
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Paris Nanterre University
Uterine Cervical Neoplasms
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)
The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer.
- Trial name
- NCT04221945
- Testing
- Pembrolizumab, Cisplatin, External Beam Radiotherapy (EBRT)
- Where
- 176 sites in United States, Australia and 28 more
- Volunteers
- 1,060 people
- Sponsor
- Merck Sharp & Dohme LLC
Pleural Effusion
Thoracic Ultrasound in the Treatment of Pleural Effusion
The main objective of the study is to assess the cost-effectiveness ratio of two management strategies of pleurisy in adults : a strategy by systematic thoracic ultrasound versus a strategy without thoracic ultrasound.
- Trial name
- ECHOPLEV (NCT02505763)
- Testing
- Strategy with thoracic ultrasound
- Where
- France
- Volunteers
- 127 people
- Sponsor
- University Hospital, Toulouse
Healthy, Wheezing, Non Wheezing Acute Respiratory Episode
Measurement of Expiratory Flow Variability for the Detection of Bronchospasm in Infants Using the Ventica® Device by Revenio
Wheezing in infants and children less than 3 years of age children is a frequent feature that might be difficult to diagnose when only the caregivers reporting is available.
- Trial name
- VENTICA (NCT04702620)
- Testing
- Ventica® device from Revenio
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemorrhoids
Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofrequency
Haemorrhoidal disease is a common and benign condition (1). Anatomically, there is an external and internal component. Only internal haemorrhoidal disease is managed by radiofrequency.
- Trial name
- RAFAELOCAL (NCT05519189)
- Testing
- Ropivacaine, No peri-anal ropivacaine infiltration
- Where
- 3 sites in France
- Volunteers
- 134 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Neuromuscular Diseases (NMD), Pneumothorax
Incidence and Risk Factors of Pneumothorax in Patients With Neuromuscular Diseases
Neuromuscular diseases can cause weakness of the respiratory muscles, leading to respiratory pump failure and respiratory insufficiency.
- Trial name
- MYOPNEUMO (NCT07909018)
- Testing
- Cough assistance device and/or thoracic mobilization and/or mechanical ventilation
- Where
- France
- Volunteers
- 31,202 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Trigeminal Neuralgia Treated by Radiosurgery
Impact of Individual Radiosensitivity on Late Toxicities of Radiosurgery in Essential Trigeminal Neuralgia
Trigeminal neuralgia is intense, electric-shock-like facial pain, most often triggered by touch, chewing or speech. It results from dysfunction of the trigeminal nerve, the 5th cranial nerve.
- Trial name
- TRITON (NCT06863324)
- Testing
- Radiation induced Lymphocyte Apoptosis diagnostic test
- Where
- 2 sites in France, Monaco
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cardiac Surgery, Ischemia Limb
Safety of the IPERF Femoral Arterial Cannula in Patients Undergoing Planned Cardiac Surgery With Extracorporeal Circulation Via Femoral Approach
This is a first-in-human, prospective, single-arm, phase I clinical study evaluating the safety of the iPerf femoral arterial cannula in patients undergoing planned cardiac surgery requiring extracorporeal circulation (ECC) via a…
- Trial name
- FIH IPERF-01 (NCT07163234)
- Testing
- Cardiac surgery
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- IPERF SAS
Haematopoietic Stem Cell Transplantation, Antivirals
Specific Immune Reconstitution After Allogeneic Transplantation and Letermovir Prophylaxis
Cytomegalovirus (CMV) is a major cause of morbidity in hematopoietic stem cell transplant recipients, with both direct effects, including CMV disease, and indirect effects, such as graft-versus-host disease (GVHD) and increased…
- Conditions
- Haematopoietic Stem Cell Transplantation, Antivirals, Cytomegalovirus Infections
- Trial name
- CIRCLE (NCT07915505)
- Testing
- Letermovir, Comparator
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Limoges
Prostatic Neoplasms
177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer
The purpose of this study is to determine whether 177Lu-PSMA-617 improves the Radiographic progression-free survival (rPFS) or Overall Survival (OS) compared to a change in Androgen receptor-directed therapy (ARDT) in metastatic…
- Trial name
- PSMAfore (NCT04689828)
- Testing
- 177Lu-PSMA-617, 68Ga-PSMA-11, ARDT
- Where
- 72 sites in United States, Austria and 12 more
- Volunteers
- 469 people
- Sponsor
- Novartis Pharmaceuticals
Myositis
A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies
The purpose of this study is to evaluate the efficacy and safety of Nipocalimab versus placebo in participants with active idiopathic inflammatory myopathies (IIM).
- Trial name
- SPIREA (NCT05379634)
- Testing
- Nipocalimab, Glucocorticoids
- Where
- 57 sites in United States, Canada and 11 more
- Volunteers
- 36 people
- Sponsor
- Janssen Research & Development, LLC
Abdominoperineal Resection
Cost-utility of Two Strategies of Perineal Reconstruction After Abdominoperineal Resection for Anorectal Carcinoma
Abdominoperineal resection performed for anorectal tumors leaves a large pelvic and perineal defect causing a high rate of morbidity of the perineal wound (40 - 60 %).
- Trial name
- GRECCAR-9 (NCT02841293)
- Testing
- Biological mesh, Primary perineal wound closure
- Where
- 20 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Toulouse
Covid19
Efficacy and Tolerance of Telerobotic vs Standard Ultrasound Exam in Children
In children with Covid-19, the diagnosis of Kawasaki Disease (KD) and pneumonia should be made very quickly. However, the regional hospitals surrounding Paris don't have the required expertise.
- Trial name
- NCT04776174
- Testing
- Ultrasound using the telerobotic Melody system
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Intrauterine Fetal Death
Causes of Fetal Death: Comparison of Diagnostic Accuracy Between Extensive and Selective Protocol Testing
Intrauterine fetal death (IUFD) is defined as the occurrence of fetal death at >20 weeks' gestation. IUFD affects about 1 in 160 pregnancies (6-7 per 1000 births).
- Trial name
- EMIBICI (NCT03214328)
- Testing
- Determination of causes of fetal death
- Where
- France
- Volunteers
- 451 people
- Sponsor
- University Hospital, Rouen
Substance Related Disorder, Personality Disorders
The Impact of the Use of the MAURISSE Application in People Suffering From an Addiction.
Substance Use Disorders (SUD) are associated with cognitive schemas that lead to care attrition and mistrust towards care. Considering this, establishing a strong, trustful relationship between the patient and the healthcare team…
- Trial name
- ALMA (NCT05964296)
- Testing
- The MAURISSE application use, Usual care
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Toulouse
IgA Nephropathy
Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients
The study was designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of iptacopan (LNP023) at a dose of 200 mg b.i.d.
- Trial name
- APPLAUSE-IgAN (NCT04578834)
- Testing
- LNP023
- Where
- 177 sites in United States, Argentina and 33 more
- Volunteers
- 517 people
- Sponsor
- Novartis Pharmaceuticals
MYT1L Syndrome
MYT1L Syndrome: a Rare Paediatric Genetic Syndrome Responsible for a Neurodevelopmental Disorder
MYT1L syndrome is a rare genetic syndrome, recently described in 2011, with paediatric onset, responsible for a neurodevelopmental disorder combining psychomotor retardation, learning difficulties and/or intellectual development…
- Trial name
- MYT1L (NCT07008612)
- Testing
- Patients with a genetic syndrome linked to the MYT1L gene, Patients with a neurodevelopmental disorder of genetic origin but not linked to MYT1L
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Rouen
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