Clinical trials: completed, in Eswatini
Neural Tube Defects, Congenital Abnormalities
Birth Outcomes In Eswatini After Transition To Dolutegravir-Based Treatment
The goal of this observational study is to assess the birth outcomes of HIV-positive women delivering in hospitals in Eswatini who are receiving dolutegravir (DTG) or other anti-retroviral (ARV) drug regimens.
- Conditions
- Neural Tube Defects, Congenital Abnormalities, Teratogens
- Trial name
- NCT05883761
- Where
- 5 sites in Eswatini
- Volunteers
- 50,075 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV/AIDS
Characteristics and Outcomes of Patients Who Received Etravirine and/or Darunavir
The objectives of this data collection activity are to: 1. Describe the baseline demographics, clinical and laboratory profile of patients who ever received darunavir (DRV) and/or etravirine (ETR), at the time of initiation on…
- Trial name
- NewHorizon (NCT04194021)
- Where
- 5 sites in Cameroon, Eswatini and 3 more
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
SARS-CoV-2 Infection, HIV Infections
Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern
The study will evaluate the clinical efficacy of different dosing regimens of the Moderna COVID-19 mRNA vaccine (100 mcg) in preventing COVID-19 disease in people who are living with HIV or have comorbidities associated with…
- Conditions
- SARS-CoV-2 Infection, HIV Infections, COVID-19
- Trial name
- CoVPN3008 (NCT05168813)
- Testing
- Moderna mRNA-1273, Moderna mRNA-1273.222, Vaccine 3 Dose
- Where
- 47 sites in Botswana, Eswatini and 5 more
- Volunteers
- 14,237 people
- Sponsor
- COVID-19 Prevention Network
Tuberculosis, Diagnoses Disease
Evaluating a New Stool Based qPCR for Diagnosis of Tuberculosis in Children and People Living With HIV
Stool4TB aims to evaluate an innovative stool-based qPCR diagnostic platform (with the capacity to become a POC diagnostic tool) in the high TB and HIV burden settings of Mozambique, Eswatini and Uganda, under the hypothesis that…
- Trial name
- Stool4TB (NCT05047315)
- Where
- 3 sites in Eswatini, Mozambique and 1 more
- Volunteers
- 1,967 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Tuberculosis
Post-Trial Tuberculosis Case Finding: A Substudy of CoVPN 3008
This substudy aims to identify cases of tuberculosis after the CoVPN 3008 clinical trial is completed.
- Trial name
- CoVPN3008TB (NCT06585683)
- Testing
- Clinical Evaluation at Day 4, Laboratory Evaluation at Day 4, Clinical Evaluation at week 26
- Where
- 41 sites in Botswana, Eswatini and 5 more
- Volunteers
- 5,694 people
- Sponsor
- COVID-19 Prevention Network
HPV Infection, Hiv
HPV Vaccination in HIV Infected and HIV Uninfected Adolescents in Eswatini
This is a multi-site, open-label non-inferiority study of the 9vHPV vaccine among a population of children, adolescents and young women living with HIV in Eswatini.
- Conditions
- HPV Infection, Hiv, HPV Vaccine
- Trial name
- NCT04982614
- Testing
- Gardasil ® 9
- Where
- 5 sites in Eswatini
- Volunteers
- 1,403 people
- Sponsor
- Columbia University
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
HIV Infections
A Cohort for Evaluation of Open-label PrEP Use and PreP Preferences Among African Women
INSIGHT is a Prospective, Observational, open-label cohort study on women in Sub-Saharan Africa on PrEP screening, informed choice, and compliance. There are no specific intervention arms or comparative treatment plans.
- Trial name
- INSIGHT (NCT05746065)
- Testing
- PrEP
- Where
- 20 sites in Eswatini, Kenya and 5 more
- Volunteers
- 3,087 people
- Sponsor
- University of Washington
COVID-19, Pneumonia, Viral
Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death
Since late December 2019, the novel human coronavirus (SARS-CoV-2) first reported in China, has spread worldwide. Vaccines to prevent SARS-CoV-2 infections have been developed in record time and several candidate vaccines have…
- Trial name
- NCT04914832
- Testing
- AZD1222
- Where
- Eswatini
- Volunteers
- 75,012 people, healthy volunteers welcome
- Sponsor
- Shabir Madhi
HIV/AIDS
Swaziland HIV Incidence Measurement Survey 2
The second Swaziland HIV Incidence Measurement Survey (SHIMS 2, 2016), is a population based HIV Impact Assessment (PHIA) that will assess the prevalence of key human immunodeficiency virus (HIV)-related health indicators.
- Trial name
- SHIMS2 (NCT04117984)
- Where
- Eswatini
- Volunteers
- 15,429 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV (Human Immunodeficiency Virus)
Link4Health: A Combination Strategy for Linkage and Retention, Swaziland
Despite increased HIV (Human Immunodeficiency Virus) infection testing in Africa, many patients never enroll in subsequent HIV care after testing or remain in care after an initial enrollment.
- Trial name
- L4H (NCT01904994)
- Testing
- POC (point-of-care) CD4+ (cluster of differentiation 4) Count, Accelerated ART (antiretroviral therapy) Initiation, Basic Care and Prevention Package
- Where
- 20 sites in Eswatini
- Volunteers
- 2,201 people
- Sponsor
- Columbia University
Malaria
Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland
This is a cluster randomised controlled trial comparing the impact of two community based malaria interventions: reactive case detection (RACD) vs reactive targeted presumptive treatment (focal mass drug administration, fMDA) on…
- Trial name
- fMDA (NCT02315690)
- Testing
- dihydroartemisinin-piperaquine (DHAp), reactive case detection
- Where
- Eswatini
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV
Advancing Community Level Action for Improving MCH/PMTCT
The goal of the ACCLAIM (Advancing Community-Level Action for Improving MCH/PMTCT) project is to increase community demand for, uptake of, and retention in Maternal and Child Health (MCH) and/Prevention of Mother-to-child…
- Trial name
- ACCLAIM (NCT01971710)
- Testing
- Community leader engagement, Community days, Community Peer Groups
- Where
- 3 sites in Eswatini, Uganda and 1 more
- Volunteers
- 187,335 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV Infections, HIV/AIDS
Evaluating the Feasibility of Point of Care Birth Testing in Eswatini
This study aims to assess the feasibility and utility of birth testing using point-of-care (POC) testing in maternity settings in Eswatini.
- Conditions
- HIV Infections, HIV/AIDS, Pediatric HIV Infection, Transmission, Perinatal Infection
- Trial name
- NCT04206878
- Testing
- Point-of-care birth test
- Where
- Eswatini
- Volunteers
- 3,316 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV Infections
Family-centered HIV Care, Viral Suppression and Retention in HIV-positive Children, Swaziland
The study will evaluate the effect of implementing a family-centered care (FAM-CARE) program (where all HIV-positive family members are seen together as a unit and receive care together) on viral suppression and retention in…
- Trial name
- FAM-CARE (NCT03397420)
- Testing
- FAM-CARE
- Where
- Eswatini
- Volunteers
- 742 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV, Contraception
The Evidence for Contraceptive Options and HIV Outcomes Trial
The ECHO Study is an open-label randomized clinical trial that will compare three highly effective, reversible methods of contraception (including a non-hormonal method) to evaluate whether there is a link between use of any of…
- Trial name
- ECHO (NCT02550067)
- Testing
- DMPA, LNG, Copper IUD
- Where
- 12 sites in Eswatini, Kenya and 2 more
- Volunteers
- 7,830 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Negative People Identified at Substantial Risk for HIV Infection
PrEP Demonstration Study in Swaziland
This stepped-wedge cluster-randomized trial is embedded in an 18-month observational cohort study that has the aim to assess the operationalization of oral Pre-Exposure Prophylaxis (PrEP) in Swaziland as an additional HIV…
- Trial name
- NCT03254550
- Testing
- PrEP Promotion Package
- Where
- 6 sites in Eswatini
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
Malaria
Combination Antimalarials in Uncomplicated Malaria
The purpose of this study is to study the efficacy of sulfadoxine-pyrimethamine on its own and compare this with efficacy of a new combination antimalarial therapy, either sulphadoxine-pyrimethamine plus artesunate or…
- Trial name
- NCT00203801
- Testing
- Sulfadoxine-pyrimethamine, Artesunate plus sulfadoxine-pyrimethamine, Artemether-lumefantrine
- Where
- 7 sites in Eswatini, Mozambique and 1 more
- Volunteers
- 700 people
- Sponsor
- University of Cape Town
HIV/AIDS
MaxART: Early Access to ART for All in Swaziland
The purpose of this study is to evaluate the feasibility, acceptability, clinical outcomes, affordability, and scalability of offering early antiretroviral treatment to all HIV-positive individuals in Swaziland's…
- Trial name
- MaxART (NCT02909218)
- Testing
- Early Access to ART for All
- Where
- Eswatini
- Volunteers
- 3,485 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
HIV/AIDS
Swaziland Safe Generations
The purpose of this study is to understand how best to provide care and treatment services to human immunodeficiency virus (HIV) positive pregnant women and their babies in Swaziland.
- Trial name
- NCT01891799
- Testing
- Option B+
- Where
- 12 sites in Eswatini
- Volunteers
- 2,518 people
- Sponsor
- Columbia University