Clinical trials: in Brazil
Healthy Volunteers - Male and Female
Neuroergonomic Analysis of a Brain-Computer Interface Device (BCI)
This study evaluates the mental workload and user experience associated with a Brain-Computer Interface (BCI) device called Exobots.
- Trial name
- NCT07922265
- Testing
- EEG-Based Brain-Computer Interface Device
- Where
- 2 sites in Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Paraná
Hematologic Test, Agranulocytosis
Hematological Safety of Dipyrone Versus Paracetamol After Dental Extractions
The goal of this clinical trial is to compare the safety of dipyrone and paracetamol when used for pain relief after dental extractions in adults.
- Conditions
- Hematologic Test, Agranulocytosis, Side Effects, Blood Pressure Monitoring
- Trial name
- NCT07918040
- Testing
- Dipyrone administration, Paracetamol (drug), blood sampling
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Matheus Furtado de Carvalho
Behavior
Acute Effects of Mat Pilates on Blood Pressure Response to Mental Stress in Higher Education Teachers
This study will investigate the acute effects of a moderate-intensity Mat Pilates session on blood pressure responses to mental stress in higher education teachers.
- Trial name
- NCT07872592
- Testing
- Acute Exercise, Control
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
HIV Infections
Long-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus)
The purpose of this study is long-term evaluation of long-acting injectable cabotegravir (CAB LA) for HIV pre-exposure prophylaxis (PrEP) in eligible participants who have completed DAIDS (Division of AIDS) sponsored studies HPTN…
- Trial name
- PALISADE (NCT06134362)
- Testing
- CAB LA
- Where
- 33 sites in Argentina, Botswana and 10 more
- Volunteers
- 2,998 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Aging Problems
Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or…
- Trial name
- VAMP-Aging (NCT07563725)
- Testing
- Laser Speckle Contrast Imaging, Handgrip Dynamometry (Muscle Strength), Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
HIV-1
Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of the potent, broadly neutralizing anti-HIV monoclonal antibodies (mAb) PGT121.414.LS alone and in combination with VRC07-523LS soon after birth in…
- Trial name
- NCT06517693
- Testing
- PGT121.414.LS, VRC07-523LS
- Where
- 19 sites in United States, Brazil and 4 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Behavior
Acute Effect of Aerobic Exercise on Cardiovascular Reactivity During a Mental Stress Test in Teachers
This study will investigate the acute effect of a single session of moderate-intensity aerobic exercise on blood pressure responses to mental stress in teachers.
- Trial name
- NCT07911865
- Testing
- Acute Exercise, Control
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
YPAP Model
Testing the Youth Physical Activity Promotion Model (YPAP) in Brazilian Adolescents
This cross-sectional observational study aims to test the original conceptual diagram of the Youth Physical Activity Promotion Model (YPAP) in Brazilian adolescents.
- Trial name
- NCT07511738
- Where
- Brazil
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Oily Skin
Evaluation of Dermal Acceptability and Comedogenic and Acnegenic Potential of a Cosmetic Product
This is a single-center, single-blind clinical study designed to evaluate the dermatological safety of a cosmetic product and to demonstrate the absence of comedogenic and acnegenic potential.
- Trial name
- NCT07768800
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Sensitive Skin
Dermal Acceptability Evaluation in Sensitive Skin
The goal of this clinical trial is to evaluate the dermatological safety and acceptability of a cosmetic product in participants with sensitive skin.
- Trial name
- NCT07848347
- Testing
- moisturizing cream
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Chemotherapy Induced Alopecia, Chemotherapy Side Effects
Pharmacokinetic Study of DA-020
Pharmacokinetic Study of DA-020
- Trial name
- NCT07402330
- Testing
- DA-020 (0.1%), DA-020 (0.2%), DA-020 (0.5%)
- Where
- 2 sites in Brazil, Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Applied Biology, Inc.
Sensitive Skin
Dermal and Ophthalmological Acceptability Assessment in Sensitive Skin
This is a single-center, single-blind clinical study designed to evaluate the safety of the investigational product through dermatological and ophthalmological clinical assessments.
- Trial name
- ADOPS (NCT07771998)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Tension-Type Headache, Orofacial Pain
Laser Therapy on Tension-type Cephalea and Orofacial Pain in Post-covid-19 Patients
Considering the auxiliary potential effect of photobiomodulation in controlling persistent CTT and TMD-related pain in patients who have been diagnosed with COVID-19, and are recovered from the viral infection, we intend to…
- Conditions
- Tension-Type Headache, Orofacial Pain, COVID-19
- Trial name
- NCT05430776
- Testing
- Photobimodulation
- Where
- 2 sites in Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Healthy Adult Participants
Single-dose Effects of Ayahuasca Compared to Esketamine on Experimentally Induced Pain
This was a randomized, parallel, double-blind clinical trial with healthy volunteers
- Trial name
- NCT07910838
- Testing
- Ayahuasca, Esketamine 0.2 mg/kg
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Xerosis, Dry Skin
Dermatological Acceptability and Efficacy in Improving Xerosis, Skin Hydration, and Barrier Function
The goal of this clinical trial is to evaluate the dermatological safety and efficacy of a moisturizing product in participants with moderate to severe xerosis of the lower limbs.
- Trial name
- NCT07820943
- Testing
- moisturizing cream
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Tuberculosis, MDR
Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients
The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB) during 96 weeks of follow-up among…
- Trial name
- PHOENIx MDR-TB (NCT03568383)
- Testing
- Delamanid (DLM), Isoniazid (INH), Pyridoxine (vitamin B6)
- Where
- 31 sites in Botswana, Brazil and 11 more
- Volunteers
- 5,832 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ulcerative Colitis (UC)
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B).
- Trial name
- NCT06619990
- Testing
- XmAb942
- Where
- 114 sites in United States, Argentina and 17 more
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Diabetes Mellitus (Type 2), Prediabetes
Evaluation of the Effectiveness of Implementing a Screening Strategy for the Diagnosis of Prediabetes and Type 2 Diabetes Mellitus in Primary Health Care in a Brazilian Municipality
Primary objective: To evaluate the effectiveness of the ARISE strategy on the proportion of individuals with confirmed T2DM diagnosis, per protocol criteria based on the PCDT-DM2 (Clinical Protocol and Therapeutic Guidelines for…
- Trial name
- ARISE (NCT07846319)
- Testing
- ARISE Strategy
- Where
- 2 sites in Brazil
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- epHealth
Implant-supported Single Crowns, Osseointegration
Influence of Prosthetic Characteristics of Implant-Supported Crowns on Peri-implant Health and Osseointegration: A Comparison Between Digital and Conventional Workflows
The objective of this prospective cohort study is to evaluate marginal bone loss and peri-implant health in patients with single dental implants requiring prosthetic rehabilitation, comparing conventional and digital methods for…
- Conditions
- Implant-supported Single Crowns, Osseointegration, Peri-Implant Health
- Trial name
- NCT07897487
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Male Intimate Harmonization Methods
Male Intimate Harmonization: Efficacy, Satisfaction, and Safety
Dissatisfaction with penile size and aesthetics may negatively affect men's self-esteem and quality of life, representing a relevant factor in psychological and sexual health.
- Trial name
- NCT07901465
- Testing
- Botulinum toxin
- Where
- Brazil
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Antony Barbosa Institute
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