Clinical trials: diabetes and obesity, open to volunteers
Type 1 Diabetes (T1D)
Utilizing Community Health Workers as Diabetes Technology Coaches for Children With Type 1 Diabetes Using Automated Insulin Delivery
This study uses community health workers (CHW) as diabetes technology coaches for African American children using automated insulin delivery systems but have an HbA1c of 8% or higher.
- Trial name
- CHWs AID Youth (NCT07154251)
- Testing
- Community Health Worker
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University Hospitals Cleveland Medical Center
Diabetes Mellitus, Type 2, Lifestyle Risk Reduction
Patient-Driven Lifestyle Modification Using FreeStyle Libre in Type 2 Diabetes Patients
We aim to provide medical nutritional therapy to patients with type 2 diabetes who are on oral hypoglycemic agents or on basal insulin only and monitor the glycemic response with flash glucose monitoring or self-monitoring of…
- Trial name
- PDF (NCT04932928)
- Testing
- FreeStyle Libre, Blood glucose meter
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Hospital
Childhood Obesity, Insulin Resistance
Leipzig Adipose Tissue Childhood Cohort
In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents.
- Trial name
- NCT02208141
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Obesity
Regional Lipolysis Insulin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults.
- Trial name
- NCT06392854
- Testing
- Insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabete Type 2
Pocket-X Gel Non-surgical Periodontal Therapy
Evaluate from a clinical and microbiological point of view the effect of an adjunctive therapy based on a thermal-gelling device Pocket-X® Gel (Hyaluronic acid, Poloxamer, 2-Phenoxyethanol, Octedine HCL, Water), in the…
- Trial name
- DEFECT_PERIO (NCT07372677)
- Testing
- Gel therapy after non surgical therapy
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Cognitive Intervention, Mild Cognitive Impairment
Cognitive Intervention for Cognitive Impairment
Mild cognitive impairment is characterized by cognitive dysfunction without impairment in instrumental activities of daily living, with aging being the primary risk factor.
- Conditions
- Cognitive Intervention, Mild Cognitive Impairment, Elderly Adults, Diabetes Mellitus
- Trial name
- NCT07747675
- Testing
- cognitive intervention
- Volunteers
- 102 people
- Sponsor
- Instituto Mexicano del Seguro Social
Gestational Diabetes, Diagnosis
Outcomes After Unified Versus Standard GDM Diagnosis
Gestational diabetes mellitus (GDM) is a condition that can affect pregnant women during pregnancy and may cause complications for the mother and the baby.
- Conditions
- Gestational Diabetes, Diagnosis, Pregnancy
- Trial name
- UPDATE-GDM (NCT06401629)
- Testing
- NPRP criteria, IADPSG criteria
- Volunteers
- 2,650 people
- Sponsor
- Qatar University
Postoperative Pain
Incidence and Clinical Features of Breakthrough Pain After Brachial Plexus Block in Diabetic Patients
This observational study aims to determine the incidence and clinical characteristics of rebound-breakthrough pain after ultrasound-guided brachial plexus block in adult patients with type 2 diabetes mellitus.
- Trial name
- NCT07833930
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Type 1 Diabetes (T1D), Registry
UK Islet Autoantibody Registry
Type 1 diabetes (T1D) is a life-long condition where the immune system destroys part of the body (the pancreas) which makes the chemical, insulin. Insulin is needed to control blood sugar levels.
- Conditions
- Type 1 Diabetes (T1D), Registry, Pre-diabetes, Screening
- Trial name
- UKIAb Registry (NCT07125365)
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Oxford
Monogenic Obesity
A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and Adults
This study is researching an experimental drug called mibavademab. The study is focused on patients with a condition called monogenic obesity.
- Trial name
- NCT07220772
- Testing
- Mibavademab
- Where
- 3 sites in Germany, Turkey (Türkiye)
- Volunteers
- 4 people
- Sponsor
- Regeneron Pharmaceuticals
Type 1 Diabetes (T1D)
Impact of Dietary Knowledge Related to Functional Insulin Therapy in Type 1 Diabetes on the Risk of Eating Disorders
Background: The management of type 1 diabetes (T1D) relies on exogenous insulin administration to compensate for the lack of endogenous insulin production.
- Trial name
- DIABEA (NCT07021456)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Obesity, Skeletal Muscle
Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity
The use of glucagon-like peptide receptor agonists (GLP-1 RAs) may have clinically important effects on skeletal muscle mass (SMM), and physical function.
- Conditions
- Obesity, Skeletal Muscle, Brain Connectivity
- Trial name
- NCT07091500
- Testing
- Exercise training, Semaglutide, Therapy Cessation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes
Multicenter, Prospective, Observational Study on the Treatment of Type 2 Diabetes With Proline Plus Empagliflozin Tablets
This study is a post-marketing, multicenter, prospective, observational study designed to evaluate the efficacy and safety of Proline Plus Empagliflozin Tablets in the real-world clinical treatment of type 2 diabetes mellitus.
- Trial name
- NCT07023172
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obstructive Sleep Apnea, Metabolic Dysfunction-Associated Steatotic Liver Disease
Association Between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea
Association between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea
- Trial name
- OSA/MAFLD (NCT07716995)
- Volunteers
- 127 people
- Sponsor
- Assiut University
Overweight, Fatty Liver Disease
The Evaluation of Orange Peel Fermentation on Body Fat Lowering Efficacy in Adults
To assess whether orange peel fermentation has the effect of reducing body fat in adults
- Trial name
- NCT04496895
- Testing
- orange peel fermentation
- Where
- Taiwan
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Healthy Overweight/Obese
The Metabolic Effects of Oral Tributyrin Administration
The goal of this double-blinded randomized clinical cross-over trial is to investigate the metabolic and appetite regulating effects of oral tributyrin (a butyrate pro-drug) administration vs placebo.
- Trial name
- TRIMET (NCT07463495)
- Testing
- tributyrin, Control
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
HIV Infections, Drug Interaction
Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older.
Several cohort studies have recently shown a significant increase in the mean age of PLWH ( People Living With HIV) and in the prevalence of people in advanced age in the various cohorts, as a result of the marked increase in the…
- Conditions
- HIV Infections, Drug Interaction, Elderly Infection, Comorbidities and Coexisting Conditions
- Trial name
- NCT06717581
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Overweight and/or Obesity
Brief Inhibitory Training for Eating - Intervention
The purpose of this study is to conduct a proof-of-concept intervention of daily inhibitory control (IC) training. Aim 1 is to examine the feasibility, acceptability, and barriers of an IC training EMI in adolescents' daily life.
- Trial name
- BITE-I (NCT07592728)
- Testing
- Daily inhibitory control training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- George Mason University
Oral Disease, Cardiovascular Diseases
Oral Health in Adults: Social Gradients and Correlation With Cardiovascular Health
Non-communicable diseases (NCDs) are rising in prevalence because of aging, unhealthy diet and sedentary lifestyle, and common NCDs are caries and periodontitis (here oral diseases) and cardiovascular disease (CVD).
- Conditions
- Oral Disease, Cardiovascular Diseases, Diabetes
- Trial name
- HUSK (NCT05758467)
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Non-Nutritive Sweetener, Type 1 Diabetes
Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)
This project will apply a novel non-nutritive sweetener (NNS) dietary assessment tool with measurement of circulating NNS levels in a pediatric population, allowing correlation of NNS exposure to clinically meaningful…
- Conditions
- Non-Nutritive Sweetener, Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
- Trial name
- NCT07434544
- Testing
- Cherry Sports Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
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