Clinical trials: Wounds and Injuries, Ankles
Ankle Sprains
The Efficacy of Hypertonic Dextrose Injection to Anterior Talofibular Ligament Sprain
Anterior talofibular ligament is the most injured ligament in ankle sprain. Investigators will include ankle sprain patients who have ankle pain or instability more than 3 months.
- Trial name
- NCT03868995
- Testing
- Tendon injection
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- Taipei Medical University WanFang Hospital
Ankle Sprain
Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain
The safety and the efficacy of the Esflurbiprofen Hydrogel Patch will be assessed in comparing with placebo in the treatment of acute pain due to ankle sprain
- Trial name
- NCT02729207
- Testing
- Esflurbiprofen Hydrogel Patch
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Ankle Sprains
Development of Chronic Ankle Instability After Acute Ankle Sprain
The goal of this observational prospective cohort study is to determine key clinical predictors for chronic ankle instability and return to sports in patients who suffered an acute ankle sprain.
- Trial name
- NCT05637008
- Where
- Belgium
- Volunteers
- 265 people
- Sponsor
- Universiteit Antwerpen
Ankle Fractures
Efficacy and Clinical Feasibility of the Ankle Muscle Power (AMP) Program for Return to Duty After an Ankle Fracture
The goal of this clinical trial is to compare two different standardized physical therapy rehabilitation programs on outcomes after an ankle fracture.
- Trial name
- AMP (NCT07173088)
- Testing
- Ankle Muscle Power (AMP) program, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brian W. Noehren
Operative Incision
Effect of Intraoperative Ankle Nerve Blocks on Postoperative Discharge in Patients Undergoing Orthopaedic Foot Surgery
Postoperative pain is an important clinical issue which negatively affects patient's satisfaction, delays discharge and repeated admission after discharge in orthopedic surgery.
- Trial name
- NCT03550677
- Testing
- general anesthesia, ankle block
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Ankle Injuries, Foot Injuries
Ankle Trauma: an Emergency Nurse Assessment Study
The ankle and/or foot injuries incidence is high. Lateral ankle sprains are most common diagnosis, while fractures represent less than 15% of final diagnosis.
- Conditions
- Ankle Injuries, Foot Injuries, Diagnosis, Treatment
- Trial name
- ATENA (NCT04126837)
- Testing
- Diagnosis and treatment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Osteochondral Lesion of Talus, Chondral Defect
AMIC vs. MFx in the Ankle
This clinical investigation is a prospective, double blind, single-centre, randomised controlled trial comparing arthroscopic autologous matrix induced chondrogenesis (AMIC®) to microfracture alone in the treatment of…
- Conditions
- Osteochondral Lesion of Talus, Chondral Defect, Microfracture
- Trial name
- AMARTA (NCT05741983)
- Testing
- Microfracture (MFx), Chondro-Gide®
- Where
- United Kingdom
- Sponsor
- Geistlich Pharma AG
Sprain
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury
Transdel Pharmaceuticals is investigating a topical cream formulation consisting of 10% ketoprofen for the local treatment of pain associated with mild to moderate acute soft tissue injury in this confirmatory Phase 3 trial.
- Trial name
- NCT01223053
- Testing
- Ketoprofen 10% cream
- Sponsor
- Imprimis Pharmaceuticals, Inc.
Ankle Fractures
Vertical Distance Between Medial and Lateral Malleolus in Normal Population
Determine variation in vertical distance between the medial and lateral malleolus in the normal population subjected to X-rays for any other causes than ankle fracture Determine the effect of weight bearing on this variation
- Trial name
- NCT04826289
- Testing
- X rays
- Where
- Egypt
- Volunteers
- 580 people
- Sponsor
- Assiut University
Ankle; Injury, Superficial, Multiple (With Foot)
The Foot and Ankle Ability Measure (FAAM) is Translated From English to Turkish and Assess the Validity and Reliability in Athletic Population Who Have Foot and Ankle Disorders.
Sport activity induces a relevant risk for lower extremities especially ankle and foot structures. Athletes who participate in basketball, volleyball and soccer are predisposed.
- Trial name
- NCT03259750
- Testing
- Foot and Ankle Ability Measure Turkish version (FAAM-T) questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Serkan Usgu
Surgical Site Infection, Complication of Surgical Procedure
Topical Antibiotics in Surgical Site
Ankle fractures are one of the most common injuries in traumatology. It is the fourth most common fracture in general population after hip, wrist, and hand fractures.
- Trial name
- NCT05363462
- Testing
- Vancomycin 1000 MG
- Where
- Mexico
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Severe Distal Tibia Injury, Severe Ankle Injury
Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol
The primary aim this prospective longitudinal observational outcomes study is to compare 18 month functional outcomes and health related quality of life (HRQoL) of patients undergoing salvage versus amputation following severe…
- Conditions
- Severe Distal Tibia Injury, Severe Ankle Injury, Severe Foot Injury, Major Soft Tissue Loss
- Trial name
- OUTLET (NCT01606501)
- Where
- 33 sites in United States
- Volunteers
- 664 people
- Sponsor
- Major Extremity Trauma Research Consortium
Ankle Sprain
Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint Pain
The purpose of this study is to evaluate the efficacy of diclofenac potassium 25 mg tablet compared with placebo taken three times a day in subjects with acute ankle sprains under 'in-use' conditions, in particular with regard to…
- Trial name
- NCT01666197
- Testing
- diclofenac potassium 25 mg tablet
- Where
- 4 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Novartis
Ankle Injuries, Foot Injury
Monster Screw System Post-Market Clinical Follow-Up Study
Post-market clinical follow-up study on the Monster Screw System
- Trial name
- NCT05190159
- Testing
- Monster Screw System
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Paragon 28
Chronic Ankle Instability
Elite Athletes With Chronic Ankle Instability Using Spraino®: A Cohort Study
Fear of re-injury and deficiencies in ankle joint function are common conditions amongst high performance (elite) athletes with chronic ankle instability (CAI), who participate in indoor sports.
- Trial name
- NCT03706729
- Testing
- Spraino
- Where
- 2 sites in Denmark
- Sponsor
- University of Southern Denmark
Foot Injuries and Disorders, Ankle Injuries and Disorders
Dexamethasone vs. Dexmedetomidine for Popliteal Nerve Block in Pain Management After Pediatric Ankle and Foot Surgery
Effect of perineurial dexamethasone and dexmedetomidine on popliteal nerve block duration for pediatric, ankle or foot surgery
- Trial name
- NCT06233565
- Testing
- 0.9%sodium chloride, Dexamethasone, Dexmedetomidine
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Athletes in Cutting Sports
Enovis High Ankle Sprain Brace Testing
The goal of this clinical trial is to learn if a new ankle brace impacts athletic motions. The main questions it aims to answer are: Does it impact motions such as running and cutting? Is it comfortable? Researchers will compare…
- Trial name
- NCT06719609
- Testing
- Ankle tape, Standard lace-up ankle brace, Standard high ankle-sprain (HAS) brace
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Ankle Sprains
Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI
The investigator's purpose is to compare the effects of talocrural joint mobilization with movement versus thrust mobilization on functional performance in subjects reporting chronic ankle instability (CAI).
- Trial name
- NCT03918473
- Testing
- Mobilization with Movement, Thrust Mobilization
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Ankle Fractures, Knee Fractures
Performance and Safety Follow-up of Bioabsorbable Headless Inion CompressOnTM Screws in the Fixation of Bone Fractures in Ankle, Knee and Elbow of Pediatric and Adolescent Patients
The study in question is a post market clinical follow up (PMCF) study to follow up the safety and performance of bioabsorbable headless compression screw Inion CompressOn in fracture fixation of the ankle, knee and elbow of…
- Conditions
- Ankle Fractures, Knee Fractures, Elbow Fractures
- Trial name
- NCT07473947
- Testing
- Fracture fixation operation
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Inion Oy
Ankle Rehabilitation, Ankle Instability
Ankle Evertor and Invertor Strength Training
The aim of this study was to investigate the effects of a 12-week ankle evertor and invertor strength training program performed on a specially designed device, which allows isolated strengthening of evertor and invertor muscles.
- Conditions
- Ankle Rehabilitation, Ankle Instability, Ankle Sprain, Ankle Injuries and Disorders
- Trial name
- NCT07820449
- Testing
- Ankle Evertor and Invertor Strength Training
- Where
- Slovenia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana