Clinical trials: Wound Closure
Venous Leg Ulcer, Diabetic Foot
AQUACEL® Ag+ Extra™ vs Cutimed® Sorbact®
Study is to provide a blinded assessment of wound closure status utilizing photographs collected as per standard of care (SOC) during the AAA RCT (WC-22-435).
- Trial name
- NCT07308678
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- ConvaTec Inc.
Colostomy Stoma
NM-IL-12 (rHuIL-12) in Subjects With Open Surgical Wounds
The purpose of this study is to determine the safety and tolerability of NM-IL-12 relative to standard of care (SOC; control) in subjects with open surgical wounds.
- Trial name
- NCT02544061
- Testing
- NM-IL-12
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Neumedicines Inc.
Incidence of Surgical Site Infection, Morality
Changing the Surgical Team for Wound Closure and Surgical Site Infection
Surgical site infection is a frequent complication after abdominal surgery. The wound closure is done at the end of the procedure when the attention of the entire team may be affected because of tiredness and reduced attention of…
- Conditions
- Incidence of Surgical Site Infection, Morality, Fascial Hernia
- Trial name
- NCT04503642
- Testing
- Changing the surgical team for wound closure
- Where
- Switzerland
- Volunteers
- 1,160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Surgical Wound, Tissue Adhesion
Skin Closure With Tissue Adhesives vs. Subcuticular Suture After Robotic Urogynecologic Procedures
To compare skin closure via subcuticular suture versus tissue adhesive (Dermabond) in urogynecological robotic surgeries. The primary outcome is incision cosmesis at the 12 week follow up visit.
- Trial name
- NCT03891004
- Testing
- Subcuticular Skin Closure, Tissue Adhesives
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- St. John Hospital & Medical Center
Wound Healing Disorder, Impaired Wound Healing
Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments
This clinical study is performed in several German, Dutch and Belgian hospitals to evaluate the efficacy of Vacuum Assisted Closure® (V.A.C.®) for the treatment of postsurgical abdominal wound healing impairments after surgery.
- Conditions
- Wound Healing Disorder, Impaired Wound Healing, Abdominal Wound Healing Disorder, Abdominal Wound Healing Impairment
- Trial name
- SAWHI (NCT01528033)
- Testing
- Vacuum Assisted Closure®, Standard conventional wound therapy
- Where
- 15 sites in Belgium, Germany
- Volunteers
- 539 people
- Sponsor
- University of Witten/Herdecke
Surgical Wound Infection
Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection
1. Infection control and health-care-associated infections and Safety of medical service providers 2. Evidence based management of common medical and surgical problems
- Trial name
- NCT05276687
- Testing
- Betadine, Vancomycin
- Volunteers
- 80 people
- Sponsor
- Assiut University
Wound Complication
Tissue Reinforcement of Incisional Closure Among High Risk Patients
Half of all individuals will undergo abdominal surgery in their lifetime. Following abdominal surgery, 30% of patients will suffer a major chronic complication with their wound closure in the first post-operative year.
- Trial name
- NCT03148496
- Testing
- Biologic Mesh, Small Bites, Large Bites
- Where
- 2 sites in United States
- Volunteers
- 163 people
- Sponsor
- The University of Texas Health Science Center, Houston
Ovarian Cancer
PROV-MESH: Prophylactic Ovarian Cancer MESH
Incisional hernia is a common complication after midline laparotomy and may significantly impact quality of life, morbidity, and healthcare costs.
- Trial name
- PROV-MESH (NCT07676370)
- Testing
- Prophylactic Mesh Placement, Negative Pressure Wound Therapy (NPWT), Standard Fascial Closure
- Where
- Spain
- Volunteers
- 152 people
- Sponsor
- Hospital Vall d'Hebron
Injury Caused by Animal Bites, Wound Infection
Incisional Negative Pressure Therapy to Prevent Animal Induced Wound Infection
Animal injuries are a significant public health issue, with the most common being bites or scratches from cats and dogs. Every year, over 40 million people in China are bitten or scratched by cats and dogs, which can lead to…
- Trial name
- NCT06558942
- Testing
- incisional negative pressure wound technology
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Thermal Injury, Deep Partial-Thickness Burn
Safety and Efficacy Study of Autologous Engineered Skin Substitute to Treat Partial- and Full-Thickness Burn Wounds
The purpose of this research study is to test how well the investigational treatment, Engineered Skin Substitutes (ESS-W), works for covering and treating burn wounds.
- Conditions
- Thermal Injury, Deep Partial-Thickness Burn, Full-Thickness Burn
- Trial name
- NCT01655407
- Testing
- Autologous Engineered Skin Substitute, Split-Thickness Autograft (AG)
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Amarantus BioScience Holdings, Inc.
Total Hip Replacement, Wound Complication
Hip DAA Closure Techniques
This study aims to analyze the difference in rates of wound complications using two different closure techniques in Direct anterior approach for primary total hip replacement.
- Trial name
- NCT06006572
- Testing
- wound closure subcuticular running stitch using 3-0 monocryl suture without skin adhesive, wound closure subcuticular running stitch using 3-0 monocryl suture with two layers of skin adhesive
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Carpal Tunnel Syndrome
A Comparison of Tissue Adhesive Material and Suture as Wound-closure Techniques Following Carpal Tunnel Decompression
Participants will be randomly assigned to suture-based wound closure (n=50) or tissue adhesive-based wound closure (n=50) with two-component skin adhesive Glubran Tiss 2®.
- Trial name
- NCT05747989
- Testing
- two-component skin adhesive, Glubran Tiss 2, skin is stitched with transcutaneous nylon sutures
- Where
- Croatia
- Volunteers
- 98 people
- Sponsor
- University of Split, School of Medicine
Surgery
Hemopatch Safety and Efficacy Evaluation Versus Standard Practice for Sealing the Dura in Cerebrospinal Fluid Leaks
Posterior fossa surgeries are generally complicated by difficulties in creating a watertight dural closure, which often requires the use of dural substitutes.
- Trial name
- NCT04419597
- Testing
- HEMOPATCH, Standard of care
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Arthroplasty, Knee Replacement, Wound Healing
Zip® Surgical Skin Closure Device vs. Staples for Skin Closure in Subjects Having Undergone Bilateral Knee Arthroplasty
Study designed to compare the Zip Surgical Skin Closure device vs. conventional staples for wound closure following bi lateral knee replacement surgery.
- Trial name
- NCT02460172
- Testing
- Zip Surgical Skin Closure, Steel Staples
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ZipLine Medical Inc.
Pain
Lidocaine Analgesia For Removal Of Wound Vac Dressings
The purpose of this prospective study is to compare pain levels and pain medication dose requirements in patients with topical negative pressure (TNP) dressings removed in a standard manner (i.v. or p.o.
- Trial name
- NCT01126359
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Utah
Surgical Site Infection
Wound Infection in Obese Women After Cesarean Delivery
The purpose of this study is to determine the surgical site infection rate and patient satisfaction for absorbable versus non absorbable suture in closure of skin at cesarean section in obese women.
- Trial name
- NCT01679379
- Testing
- Absorbable suture group, Non absorbable suture group
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
C.Delivery; Penetration, Pregnant Uterus, by Instrument, Obesity
Cesarean Wound Closure in Women With BMI 40 or Greater
The purpose of this randomized controlled prospective trial is to guide physicians on the most effective evidenced based skin closure during a cesarean section for the obese gravida, defined as a BMI of 40 or greater.
- Trial name
- NCT02549131
- Testing
- Randomizing to Suture or Staple closure of Cesarean section
- Where
- 2 sites in United States
- Volunteers
- 232 people
- Sponsor
- Pediatrix
Wound; Abdomen, Abdominal Wall
The Biomechanical Effects of Flaccid Paralysis Induced by Botulinum Toxin a After Damage Control Laparotomy
Damage control laparotomy (DCL) is a life saving maneuver used with success in trauma and acute general surgery patients. The technique involves source control of sepsis and hemorrhage with an abbreviated laparotomy.
- Trial name
- NCT01495962
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Infection Abdominal
Delayed Primary Closure Using Negative Pressure Wound Therapy
Surgical site infection rates for contaminated or dirty laparotomy wounds can be as high as 45%. Surgical management of dirty and contaminated wounds has been controversial in the literature and between surgeons.
- Trial name
- NCT04042259
- Testing
- Abthera, Open adbdomen for post-laparotomy without NPWT device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin