Clinical trials: Worm Infestation
Schistosoma Hematobium Infection, Schistosomiasis Mansoni
Safety and Efficacy of Mirazid for Schistosomiasis Treatment
Clinical Trial Phase:Phase III Primary Objectives: Compare Mirazid and Praziquantel cure rates for both Schistosoma species. Compare Mirazid and Praziquantel effect in lowering the intensity of infection for both Schistosoma…
- Trial name
- PHAR0211 (NCT01529710)
- Testing
- Myrrh
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Pharco Pharmaceuticals
Onchocerciasis
A Pharmacokinetic and Safety Study of Moxidectin to Identify an Optimal Dose for Treatment of Children 4 to 11 Years
The primary purpose of this study is to determine a dose of moxidectin for children 4 to 11 years that is equivalent to an 8 mg dose administered for treatment of onchocerciasis in people 12 years and over.
- Trial name
- NCT03962062
- Testing
- Moxidectin
- Where
- Ghana
- Volunteers
- 36 people
- Sponsor
- Medicines Development for Global Health
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults
Na-GST-1 and Na-APR-1 are proteins expressed during the adult stage of the Necator americanus hookworm life cycle that are thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02126462
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Na-GST-1/Alhydrogel®, Hepatitis B vaccine
- Where
- Gabon
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Healthy Volunteers
A Safety Study of Mebendazole in Children 2 to 10 Years of Age
The purpose of this study is to assess the safety and tolerability of mebendazole 500-mg chewable tablet formulation in a pediatric population.
- Trial name
- NCT01173562
- Testing
- Mebendazole
- Where
- Tanzania
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Onchocerciasis, Loiasis
Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa
This study aims at evaluating the diagnosis performances of the LTS-2 DEC patch for onchocerciasis compared to the gold standard which are the skin snips.
- Conditions
- Onchocerciasis, Loiasis, Diagnoses Disease, Neglected Diseases
- Trial name
- EOLoa (NCT04035174)
- Testing
- LTS-2 DEC patch, Skin snips
- Where
- Cameroon
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Research on Filariasis and Other Tropical Diseases, Cameroon
Echinococcosis, Hepatic
Hypernatremia in Hydatid Cyst Treatment
Hypertonic saline (HS) is one of the most widely used scolocidal agents in the treatment of hydatid cysts. Hypernatremia is one of the complications associated with the use of HS.
- Trial name
- NCT05090020
- Testing
- Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Neurocysticercosis
Phase I Trial Evaluating the Safety and Pharmacokinetics of Oxfendazole
The objectives of the Phase I study are to evaluate the safety and tolerance of increasing single oral doses of oxfendazole in healthy volunteers.The secondary objectives assess the pharmacokinetic profile of oxfendazole and…
- Trial name
- NCT02234570
- Testing
- Oxfendazole
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Trichuris Trichiura; Infection, Hookworm Infections
Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm
The rationale of the study is to provide evidence on the efficacy and safety of Emodepside in adults infected with Trichuris trichiura and hookworm.
- Trial name
- EMODEP_PEMBA (NCT05017194)
- Testing
- Emodepside
- Where
- Tanzania
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
Hookworms digest hemoglobin from erythrocytes for use as an energy source via a proteolytic cascade that begins with the aspartic protease, APR-1.
- Trial name
- NCT01717950
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Gluco-Pyranosylphospho-Lipid A Aqueous Formulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
HIV/AIDS
Safety and Immunogenicity Study of a DNA Vaccine Combined With Protein Vaccine Against HIV/AIDS
The primary objective of the proposed phase I trial is to evaluate the safety and tolerability of DNA-HIV-PT123 and AIDSVAX®B/E combination regimen.
- Trial name
- EV06 (NCT02376582)
- Testing
- DNA, AIDSVAX B/E
- Where
- 2 sites in Uganda
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- EuroVacc Foundation
Cysticercosis, Helminthiasis
Taenia Solium Control Case Study in Zambia
Summary Diseases due to T. solium and soil transmitted helminths (STHs) are of cosmopolitan distribution and strongly linked with poor sanitation and poverty.
- Trial name
- SANTOSOIL (NCT01368354)
- Testing
- CLTS
- Where
- Zambia
- Volunteers
- 1,197 people
- Sponsor
- University of Zambia
Schistosomiasis Mansoni, HIV
Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology
The aim of this study is to assess the impact of Schistosoma mansoni infection and its treatment on genital immunology and HIV susceptibility in Ugandan women.
- Trial name
- NCT02878564
- Testing
- Praziquantel
- Where
- Uganda
- Volunteers
- 34 people
- Sponsor
- University of Toronto
Trachoma, Lymphatic Filariases
Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin
Cluster-randomised trial comparing co-administration of Azithromycin/Ivermectin/Albendazole with separate administration of Azithromycin and Ivermectin/Albendazole.
- Trial name
- NCT03570814
- Testing
- Administration of Albendazole on Day 1, Administration of Ivermectin on Day 1, Administration of Azithromycin on Day 1
- Where
- Ethiopia
- Volunteers
- 13,511 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
Helminthiasis
Assessment of Drug Efficacy of Local Albendazole
Infections with soil-transmitted helminthes (STH) occur throughout the developing world and remain a major public health problem in the poorest communities.
- Trial name
- NCT02420574
- Testing
- albendazole BENDEX, albendazole OVIS
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- University Ghent
Schistosomiasis, Bilharzia
Arachidonic Acid Treatment Against Schistosomiasis Infection in Children
Randomized Controlled Trial: The investigational materials used in this trial were administered to subjects each day by trained clinicians.
- Trial name
- NCT02144389
- Testing
- Praziquantel (PZQ), Arachidonic acid (ARA), PZQ+ARA
- Where
- 3 sites in Egypt
- Volunteers
- 335 people
- Sponsor
- dsm-firmenich Switzerland AG
Schistosomiasis, Helminthiasis
Schistosomiasis in Formal and Non-Formal Schools in Uganda: Implications for Control Programmes
Current efforts to control schistosomiasis and soil-transmitted helminthes infections focus on the school-age population, and school-based treatment delivery programs offer a major cost advantages because of the use of the…
- Conditions
- Schistosomiasis, Helminthiasis, Anaemia
- Trial name
- NCT00463593
- Where
- Uganda
- Volunteers
- 1,293 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Soil-Transmitted Helminthiasis (STH)
Phase 3, Multi-center, Prospective, Randomized, Double-blind, Placebo- Controlled Study to Evaluate the Effectiveness and Safety of ZP5-9676 for the Treatment of Soil Transmitted Helminthiasis (STH)
This is a Phase 3, multi-center, prospective, randomized, double-blind, placebo-controlled study to evaluate the effectiveness, safety, and tolerability of ZP5-9676 compared to placebo for the treatment of STH infections.
- Trial name
- NCT06128447
- Testing
- ZP5-9676 600 mg dose
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Zero Point Five Therapeutics
Onchocercal Subcutaneous Nodule, Onchocerciasis
Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis
This study will investigate the safety and effectiveness of combination regimens in persons with onchocerciasis when it is administered after pre-treatment with ivermectin to clear or greatly reduce microfilariae from the skin…
- Conditions
- Onchocercal Subcutaneous Nodule, Onchocerciasis, Onchocerciasis, Ocular, Onchocerca Infection
- Trial name
- NCT06070116
- Testing
- Ivermectin w/ Albendazole, Ivermectin + Diethylcarbamazine + Albendazole, Moxidectin + Albendazole
- Where
- Liberia
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine