Clinical trials: Weight Management
Obesity, Overweight
A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity
Phase 2 clinical study will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of various aleniglipron (GSBR-1290) dose regimens compared with placebo in participants living with obesity or overweight with ≥ 1…
- Conditions
- Obesity, Overweight, Chronic Weight Management
- Trial name
- ACCESS II (NCT06703021)
- Where
- 10 sites in United States
- Volunteers
- 85 people
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Obesity, Weight Management
A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)
The aim of the study is to compare the efficacy and safety of XW003 injection versus semaglutide injection in Chinese adults with obesity
- Trial name
- NCT07073417
- Testing
- XW003 injection, semaglutide injection
- Where
- China
- Volunteers
- 163 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Weight Management
Semaglutide in Treatment of Obesity
This is a multicenter, randomized, open, positive parallel controlled phase III clinical trial to compare the efficacy and safety of once-weekly HD1916 and semaglutide injection and to evaluate immunogenicity in obese…
- Trial name
- NCT06604624
- Testing
- HD1916, semaglutide
- Where
- China
- Volunteers
- 462 people
- Sponsor
- CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.
Chronic Management of Body Weight
Efficacy and Safety of HRS9531 Tablet in Obese Subjects
To evaluate the efficacy of HRS9531 tablet compared with placebo in reducing body weight in obese subjects after 26 weeks of treatment.
- Trial name
- NCT06841445
- Testing
- HRS9531 Tablet
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Cancer, Cardiovascular Diseases
Healthy Lifestyles After Cancer for Adolescents and Young Adults: A Program to Reduce Cardiovascular Risk Factors
There are close to 700,000 survivors of adolescent and young adult (AYA) cancer (aged 15 to 39 at diagnosis) in the US. Survivorship for AYAs is often complicated by long-term and late-effects.
- Conditions
- Cancer, Cardiovascular Diseases, Weight Management, Pain
- Trial name
- HEALTHY-AYA (NCT05869604)
- Testing
- HEALTHY AYA, Education Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Weight Management
GV101 in Healthy Obese Participants
The purpose of this trial is to evaluate the efficacy and safety of GV101 for weight loss over a range of doses in participants with obesity.
- Trial name
- NCT06979505
- Testing
- GV101
- Where
- 20 sites in United States, Israel
- Volunteers
- 131 people
- Sponsor
- Graviton Bioscience Corporation
Pregnancy, Postpartum
Usability Study of Gestational and Postpartum Weight Management Program
The principal aim of this study is to evaluate the usability of the Hope-D gestational and 6 months postpartum weight management program.
- Conditions
- Pregnancy, Postpartum, Obese Pregnant Women, Weight Management
- Trial name
- Hope-D_Use (NCT07272824)
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Weight Management
Tolerance and Appetite Reduction of a Nutritional Solution With Intragastric Gelation Properties
The physical properties of a food product, such as its gelling properties in the stomach can influence how full a person may feel after its consumption.
- Trial name
- NCT07127198
- Testing
- Beverage Variant 1 (low gelation properties), Beverage Variant 2 (medium gelation properties), Beverage Variant 3 (high gelation properties)
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Chronic Weight Management
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide
This will be a phase I, randomized, double-blind, placebo-controlled. This study will be conducted in three periods: the screening period, the treatment period, and the follow-up period.
- Trial name
- NCT06972992
- Testing
- ASC47 +Semaglutide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited
Chronic Weight Management
A Study to Evaluate the Efficacy, Safety, and Tolerability in Participants With Obesity or Overweight With Weight-Related Comorbidities
This randomized, double-blind, placebo-controlled phase IIa study is designed to evaluate the efficacy, safety, and tolerability of ASC30 Tablets and ASC30 Tablets A1.
- Trial name
- NCT07002905
- Where
- 6 sites in United States
- Volunteers
- 125 people
- Sponsor
- Ascletis Pharma (China) Co., Limited
Chronic Weight Management
Long-term Efficacy and Safety of HRS-7535 Tablets in Obese Subjects
The Objective of this trial is to evaluate the long-term safety, tolerability, weight loss efficacy and metabolic benefits of HRS-7535 tablets inobesity.
- Trial name
- NCT06671821
- Testing
- HRS-7535
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Weight Management, Stress
Ashwagandha Extract for Weight and Stress Management in Overweight and Obese Adults
This study is designed to evaluate the effects of KSM-66 Ashwagandha root extract (300 mg daily) on weight management and stress reduction in overweight and obese adults.
- Trial name
- NCT07215455
- Testing
- Ashwagandha 300 mg standardized root extract
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
the Management of Weight Regain After Gastric Bypass by Endoscopic Suturing
Assessment of the Overstich Technique for the Management of Weight Regain After Gastric Bypass.
Prospective multicenters randomized study to compare the efficiency and the socioeconomic impact of the endoscopic management (Overstitch technique) of weight regain after gastric bypass surgery to non invasive treatment
- Trial name
- APOLLO (NCT02048033)
- Testing
- Regular endoscopy + endogastric suturing, Regular endoscopy
- Where
- 7 sites in France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Weight Management in Adult Patients With Obesity or Overweight
Phase I Study of XTL6001 Injection in Healthy and Obese Subjects
This is a multicenter, randomized, double-blind, placebo-controlled Phase I study to evaluate safety, PK and PD of single ascending dose (SAD) and multiple ascending dose (MAD) of XTL6001 injection in healthy and obese adult…
- Trial name
- NCT07205432
- Testing
- XTL6001
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shanghai Xitaili Biomedicine Technology co., Ltd.
Weight Management, Cardiovascular (CV) Risk
Feasibility, Acceptability, and Validation of a User-friendly Diet Quality Tool in Adults From Ambulatory Nutrition Clinics
The study design for Perceptions and Learning About a Diet Tool (PLATE) was a prospective online dietary intake survey in adults engaged in ambulatory nutrition counseling.
- Conditions
- Weight Management, Cardiovascular (CV) Risk, Metabolic and Nutritional Disorders
- Trial name
- PLATE (NCT07109011)
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Pennsylvania
Longevity, Quality of Life
Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures
The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity.
- Conditions
- Longevity, Quality of Life, Mood, Inflammation
- Trial name
- NCT07092605
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Obesity, Weight Loss
Metabolic and Behavioural Effects of CONTRAVE as Potential Mechanisms of Weight Loss in Adults With Obesity
Obesity is a common chronic disease linked with increased risk for other illnesses and earlier death. Our team and others have shown that many bodily and psychological changes occur when individuals are on calorie-restricted…
- Conditions
- Obesity, Weight Loss, Weight Management, Dietary Intervention
- Trial name
- NCT06809166
- Testing
- Contrave, Diet Program
- Where
- 3 sites in Canada
- Volunteers
- 40 people
- Sponsor
- The Royal's Institute of Mental Health Research
Breast Cancer Survivorship, Eating Behavior
Mindful Eating in Breast Cancer Survivors: A Pilot Study in Türkiye
The goal of this clinical trial is to explore whether a mindful eating intervention can improve eating behaviors and support sustainable weight management among female breast cancer survivors in Türkiye who have completed active…
- Conditions
- Breast Cancer Survivorship, Eating Behavior, Weight Management, Mindful Eating Intervention
- Trial name
- MIND-BR (NCT07007104)
- Testing
- Mindful Eating Intervention, Oncology Nutrition Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Acibadem University
Weight Reduction, Obesity
Effects of Protein-Enriched Meal on Liver, Kidney or Bone: a Randomized Controlled Trial
This study will examine whether a higher protein meal replacement diet (consisting of 1 gram of protein per pound lean body mass) is more effective in causing weight loss compared to a standard meal replacement protein diet…
- Conditions
- Weight Reduction, Obesity, Weight Management
- Trial name
- NCT01030354
- Testing
- Herbalife Meal Replacements
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Weight Management
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of ASC30 Tablets and ASC30 Tablets A1 in Participants With Obesity
This is a phase I, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, efficacy, food effect of ASC30 Tablets or ASC30 Tablets A1 in…
- Trial name
- NCT06680440
- Testing
- ASC30
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited