Clinical trials: Weight Maintenance
Obesity, Overweight
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM.
- Conditions
- Obesity, Overweight, Chronic Weight Management, Type2 Diabetes Mellitus
- Trial name
- NCT07654374
- Testing
- aleniglipron
- Where
- 74 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Obesity, Diabetes
Framingham State Food Study
This study will evaluate the effects of dietary composition on energy expenditure and chronic disease risk factors, while also exploring physiological mechanisms underlying these effects.
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- (FS)2 (NCT02068885)
- Testing
- Feeding study
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Obesity
Using the Energy Gap to Prevent Weight Regain
The major challenge in obesity treatment is not producing weight loss but in preventing that weight from being regained. There are many different methods to lose weight, but there are no recommendations for how you can best…
- Trial name
- Lose-It (NCT00429650)
- Testing
- increased exercise, diet, Exercise and Diet
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Intermittent Eating on Sustaining Weight-loss in Obesity
Weight regain after weight loss is a major problem in the treatment of obesity. Two novel types of intermittent fasting recently have received more attention: the 5:2 diet and time-restricted eating (TRE).
- Trial name
- INTEREST (NCT05453617)
- Testing
- Time-restricted eating, The 5:2 diet
- Where
- China
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Overweight, Obese
Lose 2 Win A Novel Method to Motivate Weight Loss Maintenance Among College Students
Investigators are conducting a randomized controlled trial with overweight and obese college students on the University of Minnesota campus.
- Trial name
- L2W (NCT02021383)
- Testing
- Bi-weekly in person meetings with a Registered Dietician, Financial incentives for weight loss maintenance
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity, Overweight
The Effect of Repeated Lifestyle Intervention on Weight Loss Maintenance
In Denmark and the western world, there is an increasing prevalence of obesity probably due to a combination of inadequate daily physical activity and a high energy intake.
- Trial name
- NCT02040753
- Testing
- Intensive Lifestyle Intervention
- Where
- Denmark
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Overweight
Weight Regain After Consumption of Food Supplement and Interventional Diet Program
Effect of the dietary supplement (FAT-BINDER DAMM) on weight regain after 9 months of control weight program
- Conditions
- Obesity, Overweight, Weight Loss, Body Weight Changes
- Trial name
- fat-binder (NCT03554525)
- Testing
- Fat-binder damm
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Obesity (BMI Equal to or >30), Postmenopausal Symptoms
Time-Restricted Eating and Personalized Energy-Restricted Diet in Obese Postmenopausal Women
This clinical study aims to compare the effects of time-restricted eating and a personalized energy-restricted diet on anthropometric measurements, body composition, biochemical parameters, blood pressure, handgrip strength…
- Conditions
- Obesity (BMI Equal to or >30), Postmenopausal Symptoms, Sleep Quality
- Trial name
- NCT07874399
- Testing
- Time-Restricted Eating, Personalized Energy-Restricted Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Weight Loss
A Virtual Reality Intervention to Improve Weight Maintenance
The purpose of this study is to determine if use of a virtual reality platform, Second Life, is more effective than traditional face-to-face methods for maintaining weight loss in overweight and obese individuals.
- Trial name
- NCT01841372
- Testing
- Second Life, Group Phone Conference Call
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- University of Kansas Medical Center
Obesity
Personalized Nutrition and eHealth: Lifestyle Intervention (LION) Study for Weight Loss Maintenance
Despite standardized intervention strategies, weight loss and weight loss maintenance largely differ from person to person. Factors which may contribute to these individual differences is current object of research.
- Trial name
- LION (NCT04023942)
- Testing
- Weight maintenance intervention
- Where
- Germany
- Volunteers
- 272 people
- Sponsor
- Technical University of Munich
Obesity, Overweight
FitLink: Improving Weight Loss Maintenance by Using Digital Data to Provide Support and Accountability
Most adults in the U.S. are overweight or obese and find maintenance of weight loss difficult. This study is designed to aid in the development of a lifestyle modification program that can facilitate weight loss maintenance…
- Conditions
- Obesity, Overweight, Overweight and Obesity, Weight Loss
- Trial name
- NCT03337139
- Testing
- Gold Standard Behavior Therapy for Weight Loss, Standard Remote Behavior Therapy for Weight Loss, Digital Data Sharing Behavior Therapy for Weight Loss
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Drexel University
Alpha1-proteinase Inhibitor Deficiency, Emphysema
Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency
This is a randomized, placebo-controlled, double-blind, multicenter phase III/IV study to compare the efficacy and safety of Zemaira® with placebo in subjects with emphysema due to alpha1-proteinase inhibitor deficiency.
- Trial name
- NCT00261833
- Testing
- Alpha1-proteinase inhibitor
- Where
- 28 sites in United States, Australia and 11 more
- Volunteers
- 180 people
- Sponsor
- CSL Behring
Obesity
The Role of No-Calorie Beverages Within a Weight Loss Program
The no calorie drink study is looking for over 300 people to participate. The study is evaluating the effect of no calorie beverages on weight loss and weight maintained over time in people who drink diet beverages every day as…
- Trial name
- NCT01766700
- Testing
- 2 no calorie beverages per day, 2 water beverages per day
- Where
- 2 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight, Obesity
Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance
Dietary protein is a key element of most effective weight loss regimens. This study will investigate the effects of consuming soy protein on body composition and cardiometabolic health within the context of an effective weight…
- Conditions
- Overweight, Obesity, Weight Loss
- Trial name
- NCT03248804
- Testing
- Soy group, Non-soy group
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight and Obese Adults, BMI >= 23
Dose Response of Leucine on Muscle Maintenance During Weight Loss
The objective of this research is to determine if there is dose response of leucine on muscle maintenance during 4-week of alternate-day fasting (ADF) on blood parameters, body composition, mood and parameters related to appetite…
- Trial name
- NCT07583875
- Testing
- leucine
- Where
- Singapore
- Volunteers
- 92 people
- Sponsor
- Nanyang Technological University
Obesity
Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity
The goal of this clinical trial is to investigate whether a Ketogenic Diet (KD) can increase Total Energy Expenditure (TEE), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.
- Trial name
- KETOWEI (NCT06736028)
- Testing
- Diet Therapy, Calorie Restriction, Behavioral Support
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Healthy
Caloric Titration Method of Weight Loss and Maintenance
Study examined the effectiveness of daily self-weighing to prevent age related weight gain.
- Trial name
- NCT03553160
- Testing
- Frequent Self-Weighing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cornell University
Overweight , Obesity
Phase 2 Study of MWN109 Tablet for Weight-Loss Maintenance in Participants With Overweight or Obesity
This study adopted a randomized, open-label design, aiming to preliminarily explore the weight-loss maintenance effect of MWN109 tablets when administered continuously for 24 weeks in non-diabetic overweight or obese…
- Trial name
- NCT07804797
- Testing
- MWN109 1, MWN109 2
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Binge-Eating Disorder, Obesity
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment
This study will test the effectiveness of lisdexamfetamine (LDX) medication as a maintenance therapy for the treatment of binge-eating disorder (BED) in patients with obesity.
- Trial name
- NCT03926052
- Testing
- Lisdexamfetamine Dimesylate
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Yale University
Breast Cancer, Insomnia
The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-behavioral intervention for…
- Conditions
- Breast Cancer, Insomnia, Weight Gain
- Trial name
- COIN (NCT05780814)
- Testing
- Cognitive-Behavioral Therapy for Insomnia (CBT-I), Sleep Education Control (EDU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University