Clinical trials: Weight Control
OSA, Overweight or Obesity
A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Study GZRA is a master protocol that will support 2 independent studies, GZ01 and GZ02. Participants will be assigned to the appropriate study prior to randomization.
- Trial name
- ATTAIN-OSA (NCT06649045)
- Testing
- Orforglipron
- Where
- 66 sites in United States, Argentina and 7 more
- Volunteers
- 712 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes, Morbid Obesity
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
The goal of this randomized clinical trial is to evaluate glycemic control in patients with morbid obesity and type 2 diabetes after Roux-en-Y gastric bypass (RYGBP) and RYGBP with fundus resection.
- Conditions
- Type 2 Diabetes, Morbid Obesity, Bariatric Surgery
- Trial name
- NCT05854875
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Roux en Y gastric bypass with fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Postoperative Pain, Hip Arthroplasty
Trial of Weight Bearing Status Following Femoral Revision With Tapered, Fluted, Titanium Stems
This is a prospective, randomized controlled trial of all patients undergoing femoral revision at Thomas Jefferson University Hospital and Rothman Institute undergoing femoral revision surgery with the use of a modern titanium…
- Trial name
- NCT04592939
- Testing
- immediate weight bearing after surgery, 6 weeks of toe-touch weight bearing after surgery
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Insulin Resistance, Obesity
A Study of the Effect of INCB013739 on Cortisone Reducing Enzyme Activity in Obese People Predisposed to Diabetes
The purpose of this study is to determine whether the investigational drug INCB013739 has an effect on systemic and adipose tissue 11-HSD1 activity in obese, insulin resistant subjects.
- Trial name
- NCT00398619
- Testing
- INCB13739
- Where
- 2 sites in United States
- Sponsor
- Incyte Corporation
Obesity and Obesity-related Medical Conditions
Management of Obese Patients With Gastroesophageal Reflux Disease .
The aim of this study is to evaluate the efficacy Sleeve gastrectomy with cruroplasty with or without ligamentum teres wrapping for management of morbidly obese patients with concomitant reflux symptoms.
- Trial name
- NCT06599489
- Testing
- surgery ..operation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hossam Mahmoud Ibrahim
Obesity
Efficacy and Safety Study of Sibutramine in Overweight Non-Diabetic Malaysian Population
The primary objective of this study was to evaluate the efficacy and the safety of sibutramine vs. placebo in combination with a hypocaloric diet on weight-loss in overweight and obese Malaysian subjects.
- Trial name
- NCT00677391
- Testing
- Sibutramine
- Volunteers
- 103 people
- Sponsor
- Abbott
Nasopharyngeal Carcinoma, Nutritional Support
Effect of Oral Nutritional Supplements on Body Weight Loss of Patients With Nasopharyngeal Carcinoma
Concurrent chemoradiotherapy(CCRT) is the principal treatment for nasopharyngeal carcinoma(NPC). Studies have shown that malnutrition is very common in patients with NPC after chemoradiotherapy.
- Trial name
- NCT04823468
- Testing
- Abbott®Ensure, Intensity Modulated Radiation Therapy, cisplatin
- Where
- 13 sites in China
- Volunteers
- 236 people
- Sponsor
- Jinsheng Hong
Overweight, Metabolic Syndrome
Effectiveness of IRK-19® on Body Weight Control
This randomized, double-blind, placebo-controlled, and parallel clinical study aims to investigate the effectivness of a pumpkin seed extract (IRK-19®) on weight management.
- Trial name
- NCT05542160
- Testing
- Pumpkin seed extract (IRK-19)
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Greenyn Biotechnology Co., Ltd.
Diabetes Mellitus, Type 2, Obesity
Egg Consumption and Glycemic Control in Individuals With Pre- and Type II-diabetes
The intent of this study is to examine the extent to which daily incorporation of egg into a diet improves glycemic control, insulin sensitivity, lipid profiles, and body composition in overweight and obese adults with pre- and…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Pre Diabetes
- Trial name
- NCT03272074
- Testing
- Egg and egg white
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Florida State University
Obesity, Appetite Disorders
Impact of a Satiating Diet in Obese Men With a Low Satiety Phenotype
The global research project was organized as a clinical process starting with an evaluation aiming at the determination of a diagnosis pertaining to the degree of satiety signal capacity.
- Trial name
- NCT03128697
- Testing
- Satiating diet, Control diet
- Where
- 2 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Laval University
Type 2 Diabetes Mellitus
GLP-1 and Non-exercise Activity Thermogenesis in RHZ
Rationale: Treatment with glucagon-like peptide 1 (GLP-1) has been shown to reduce plasma glucose levels to a further extent when added to standard therapy in type 2 diabetes mellitus.
- Trial name
- NCT01638260
- Testing
- Liraglutide, NEAT
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Maastricht University Medical Center
Infertility, Weight Loss
Weight Loss on IVF Outcomes in Overweight and Obese Infertile Women
The aim of this study is to determine whether weight loss prior to in vitro fertilization (IVF) improves live birth outcomes in overweight and obese infertile women.
- Conditions
- Infertility, Weight Loss, Obesity, IVF
- Trial name
- NCT07174817
- Testing
- weight loss
- Where
- China
- Volunteers
- 197 people
- Sponsor
- Peking University People's Hospital
Overweight and Obesity, Weight Loss
microRNA Testing for Identification of Personalized Weight Management
Certain blood markers are related to one's ability to successfully lose weight by diet and exercise. Currently, the laboratory tests used to measure these blood markers are expensive and time-consuming.
- Trial name
- NCT04217850
- Testing
- 250 kcal Dietary Energy Restriction, Aerobic Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Longevity, GLP-1
Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation
The goal of this randomized, controlled trial is to evaluate the effectiveness of alternative therapies (metformin alone, with rapamycin, and with low-dose naltrexone) in maintaining weight loss in patients weaning off GLP-1…
- Conditions
- Longevity, GLP-1, Geroscience, Aging
- Trial name
- NCT07092618
- Testing
- Metformin, Rapamycin, Naltrexone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- AgelessRx
Obesity
Effects of a Probiotic on Body Weight
Probiotics administration is associated with health benefits on gut barrier integrity and immunological functions of the gastrointestinal tract.
- Trial name
- NCT01106924
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight and Obesity
Teaching Obesity Treatment Options to Adult Learners Intervention Via VA Video Connect
The goal of this study is to assess the feasibility and acceptability of Teaching Obesity Treatment Options to Adult Learners (TOTAL intervention), which includes an educational video about obesity treatment options within VA in…
- Trial name
- TOTAL (NCT04878289)
- Testing
- TOTAL with Motivational Telemedicine Sessions
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Obesity
Effectiveness of Rice Germ Supplementation on Body Composition, Metabolic Parameters, Satiating Capacity and Amino Acid Profiles in Obese Postmenopausal Women
Rice germ (RG) may be a safe and effective dietary supplement for obesity in menopause, considering its high protein content and considerable amounts of essential amino acids, good fatty acids, and fiber.
- Trial name
- NCT04695418
- Testing
- Rice Germ
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Obesity, Diabetes Mellitus, Type 2
A Study of the Efficacy and Safety of Topiramate in the Treatment fo Obese, Type 2 Diabetic Patients Treated With Metformin
The purpose of this study is to compare the efficacy (in terms of weight and hemoglobin type A1c [HbA1c]) and safety of topiramate (96 milligrams[mg] or 192 mg daily) with placebo in the treatment of obesity in Type 2 diabetic…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00231660
- Testing
- topiramate
- Volunteers
- 211 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Mediterranean Diet, Intermittent Fasting
Effects of Different Dietary Models on Eating Behavior and Obesity Management in Overweight and Obese Individuals
The aim of this study is to examine the effects of different diet models (Mediterranean diet, time-restricted feeding and standard diet application) applied to overweight and obese individuals on eating behavior and obesity…
- Conditions
- Mediterranean Diet, Intermittent Fasting, Diet
- Trial name
- Obesity (NCT07055620)
- Testing
- Mediterranean diet, Standard diet, standard diet and time-restricted feeding
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Selcuk University
Metabolic Syndrome, Obesity
Kefir and Metabolic Syndrome
Metabolic syndrome is a cluster of metabolic disorders which increases the risk for diabetes and cardiovascular disease. In recent years, research has shown that probiotics may have positive effects on metabolic syndrome…
- Conditions
- Metabolic Syndrome, Obesity, Hypertension, Hyperlipidemias
- Trial name
- NCT03966846
- Testing
- Kefir, Milk
- Volunteers
- 62 people
- Sponsor
- Izmir Katip Celebi University