Clinical trials: Vulvodynia
Bacterial Vaginosis, Candidiasis
Vaginal Ecosystem and Network in the United States Study
The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions.
- Conditions
- Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause
- Trial name
- VENUS (NCT06472765)
- Testing
- Vaginal Swab Collection
- Where
- 21 sites in United States, Canada
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Vaginal Biome Science
Vestibulodynia
A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia
The main objective of this study is to compare the efficacy of botulinum toxin injections on vestibulodynia pain compared to a group treated with a placebo.
- Trial name
- VESTIBULE (NCT02858219)
- Testing
- Botulinum Toxin Type A, Saline solution, Indexes
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Vestibulodynia
Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia
Vulvodynia is a debilitating chronic vulvar pain lasting at least 3 months without a clear identifiable cause that is challenging to treat effectively.
- Trial name
- NCT03390049
- Testing
- Fractional CO2 Laser Treatment
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Vulvodynia
Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort
This study will evaluate the efficacy and safety of two vaginal products compared with that of placebo to determine if the two products are better than placebo in the relief of vaginal discomfort.
- Trial name
- NCT00590590
- Testing
- Lidocaine/Diphenhydramine, lidocaine
- Where
- 48 sites in United States, Canada
- Volunteers
- 105 people
- Sponsor
- Lumara Health, Inc.
Vulvodynia
A Randomized Clinical Trial for Women With Vulvodynia
This study will evaluate the relative effectiveness of cognitive-behavioral therapy and supportive psychotherapy for the treatment of women with vulvodynia.
- Trial name
- NCT00607490
- Testing
- Cognitive-Behavioral Therapy, Supportive Psychotherapy
- Volunteers
- 50 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Vulvodynia
The Effectiveness of Vestibulectomy
Women with vulvodynia will fill out a questionnaire and undergo a gynecological examination before and 6 months after vestibulectomy. The investigators hypothesize that pain will decrease.
- Trial name
- NCT00873301
- Testing
- vestibulectomy
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Western Galilee Hospital-Nahariya
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Vulvodynia, Vulvodynia, Generalized
Effect of Two Acupuncture Protocols on Vulvodynia
Vulvodynia is a common condition in women (16%); however, at this time there is no known effective non-pharmacological therapy reported.
- Conditions
- Vulvodynia, Vulvodynia, Generalized, Vulvar Vestibulitis, Vulvar Pain
- Trial name
- Acu/Vul-pain (NCT03481621)
- Testing
- Acupuncture, Standard care
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- McLean Center for Complementary and Alternative Medicine, PLC
Vulvodynia, Dyspareunia
Therapy to Prevent Sexual Pain in Breast Cancer Survivors
The purpose of this protocol is to determine whether pain with sexual intercourse can be reduced in menopausal, breast cancer survivors and to evaluate the effectiveness of a non-hormonal therapy (Lidocaine Liquid) vs.
- Conditions
- Vulvodynia, Dyspareunia, Breast Cancer, Menopause
- Trial name
- NCT01539317
- Testing
- Topical liquid lidocaine, Topical saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OHSU Knight Cancer Institute
Vulvodynia, Mycoses
Prospective Data Bank Creation to Study Vaginal Conditions
The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent…
- Conditions
- Vulvodynia, Mycoses, Bacterial Vaginosis, Preterm Labor
- Trial name
- CRIPB-13-002 (NCT01829204)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Stress Urinary Incontinence, Surgical Incision
Use of a Dual-agent Local Analgesic (Bupivacaine-meloxicam) for Abdominal Incisions in Patients Undergoing Retropubic Mid-urethral Sling Surgery
This study will compare the use of a dual-agent local analgesic (bupivacaine-meloxicam) for abdominal incisions in patients undergoing retropubic mid-urethral sling surgery to see if narcotic usage and pain are impacted.
- Conditions
- Stress Urinary Incontinence, Surgical Incision, Pain Vulva
- Trial name
- NCT05702827
- Testing
- Bupivacaine-Meloxicam
- Where
- 2 sites in United States
- Volunteers
- 148 people
- Sponsor
- TriHealth Inc.
Provoked Localized Vulvodynia
M-gCBT for Women With Provoked Localized Vulvodynia
The purpose of this study is to learn more about Mindfulness based Group Cognitive Behavior Therapy (M-gCBT) as a treatment for Provoked Localized Vulvodynia (PLV).
- Trial name
- NCT02919813
- Testing
- Mindfulness Based Group Cognitive BehaviorTherapy, Educational Seminars
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Oregon Health and Science University
Painful Bladder Syndrome, Interstitial Cystitis
Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome
Purpose: 1. To demonstrate better symptoms control (pain, urinary urgency and frequency) with sacral neuromodulation (SNM) in patients with interstitial cystitis /painful bladder syndrome (IC/PBS) using a stimulation frequency of…
- Conditions
- Painful Bladder Syndrome, Interstitial Cystitis, Pelvic Floor; Insufficiency, Bowel Dysfunction
- Trial name
- NCT01312259
- Testing
- Changing the Interstim parameter of '' Frequency" in patients with Interstitial Cystitis
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Pelvic and Sexual Health Institute
Vulvodynia
An Internet-based Information Platform for Vulvodynia Patients
Vulvodynia is a very common but vastly under-diagnosed and under-treated gynaecological condition that leads to extreme suffering for both the women involved but also their partners.
- Trial name
- EMBLA (NCT02809612)
- Testing
- Internet-based platform
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Vestibulodynia
Feasibility Study for Provoked Vestibulodynia
The feasibility and acceptability of a somatosensory rehabilitation program and an educational pain management program will be investigated in women with provoked vestibulodynia.
- Trial name
- NCT05342402
- Testing
- Somatosensory Rehabilitation Program, Educational Pain Management Program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Provoked Vestibulodynia
Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
This randomized trial, nicknamed the COMFORT (Cognitive therapy or Mindfulness FOR Treatment of pvd) study, will compare the effects of an 8-session group Mindfulness-based Cognitive Therapy (MBCT) to an 8-session group Cognitive…
- Trial name
- COMFORT (NCT01704456)
- Testing
- Mindfulness-based Cognitive Therapy, Cognitive Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- University of British Columbia
Vestibulodynia
Pilot Study to Assess the Efficacy of Cognitive-behavioral Couple Therapy for Provoked Vestibulodynia
The current pilot study aims to assess the feasibility and preliminary efficacy of a novel, 12-week targeted couple intervention (CBCT) for women with vulvodynia and their partners.
- Trial name
- NCT01582373
- Testing
- Cognitive-behavioral couple therapy
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Université de Montréal
Vulvodynia
Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareunia and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT02773641
- Testing
- Botulinum Toxin Type A, Sterile Saline Solution
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Vulvodynia (Chronic Vulvar Pain), Vulvar Vestibulitis
Does a Virtual Program for Pelvic Pain Improve Pain and Sexual Outcomes in Individuals With Provoked Vestibulodynia?
The goal of this clinical trial is to learn if a 3-month online pelvic health program works to improve pain and sexual wellbeing in adult women with chronic genital pain.
- Conditions
- Vulvodynia (Chronic Vulvar Pain), Vulvar Vestibulitis, Vestibulodynia, Provoked Vestibulodynia
- Trial name
- PVD (NCT06999395)
- Testing
- Virtual online pelvic health program
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Queen's University
Episiotomy Wound, Laser
Therapeutic Efficacy of Erbium:YAG Laser in Postpartum Patients With Episiotomy Scars
Episiotomy is a planned surgical incision to the perineum and posterior wall of the vagina during the second stage of labor. The fibrotic and sclerotic scar tissue formed as part of the healing process of episiotomies may cause…
- Conditions
- Episiotomy Wound, Laser, Vulvodynia, Vulva Pain
- Trial name
- NCT05793476
- Testing
- Fotona Dynamis Er:YAG Laser System
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Istanbul University - Cerrahpasa