Clinical trials: Volunteer
Healthy
Punicalagin and Hydroxytyrosol Mixture on Different Inflammatory Markers
A crossover trial was carried out in healthy volunteers aged 45-70 years and BMI <30 kg/m2. Subjects consumed a Antioxidant Supplement (AS) containing 65 mg of punicalagin mixed with 3.3 mg of hydroxytyrosol 3 times daily or a…
- Trial name
- PROBELTEII (NCT02042742)
- Testing
- punicalagin and hydroxytyrosol mixture, Control supplement (maltodextrin)
- Where
- Spain
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Local Anesthesia
Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in Healthy Adult Volunteers
The purpose of this study is to evaluate the effectiveness of administering Lidocaine and Epinephrine using an iontophoretic device treatment to provide local anesthesia to healthy adult volunteer subjects undergoing venipuncture.
- Trial name
- NCT00889642
- Testing
- Iontophoretic Drug Delivery System with Lidocaine/Epinephrine, Iontophoretic Drug Delivery System with Epinephrine
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dharma Therapeutics Inc.
Healthy Volunteers
Study Investigating the Effect of Idalopirdine on Cardiac Repolarisation in Healthy Men
To evaluate the effect of idalopirdine (120 and 360 mg) on cardiac repolarisation in healthy men.
- Trial name
- NCT02436486
- Testing
- ldalopirdine 120 mg, Idalopirdine 360 mg, Moxifloxacin 400 mg
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Chronic Hepatitis B
A Study of ALG-000184 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects
The goal of this clinical trial is to learn if ALG-000184 is safe, well-tolerated, and works to treat chronic hepatitis B virus (HBV) infection.
- Trial name
- NCT04536337
- Testing
- ALG-000184, Entecavir
- Where
- 10 sites in Australia, China and 4 more
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Healthy Volunteers
A Study of LY2979165 and LY2140023 in Healthy Volunteers
This study will be comprised of 2 parts, Part A and Part B, both in healthy male participants. Part A of the study will investigate the safety of intravenous (IV) ketamine administration after single oral doses of LY2979165…
- Trial name
- NCT01524237
- Testing
- LY2979165, LY2140023, Ketamine
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Cough
Repeat Doses of BAY 1817080 in Healthy Males & Proof of Concept in Chronic Cough Patients
To investigate the safety and tolerability of ascending repeated oral doses of BAY1817080 in healthy volunteers(Part1). To investigate the safety, tolerability and efficacy of BAY1817080 in patients with refractory chronic…
- Trial name
- NCT03310645
- Testing
- BAY1817080
- Where
- 7 sites in United Kingdom
- Volunteers
- 87 people
- Sponsor
- Bayer
Healthy Volunteers
Bioavailability and Food Effect Study of Two Formulations of TAK-906
The aim of this study is to understand how TAK-906 tablets and capsules are processed by the body in healthy adults under fasting conditions and also how TAK-906 tablets are processed by the body when taken with a high fat high…
- Trial name
- NCT04831502
- Testing
- TAK-906
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Takeda
Parkinson's Disease
Pharmacokinetic-Pharmacodynamic Interaction Between Four Different Single Doses of BIA 3-202 and a Single Dose of Levodopa/Carbidopa (100/25 mg)
The purpose of this study is to investigate the tolerability, pharmacokinetic profile of BIA 3-202 and its metabolites, and the pharmacokinetic and pharmacodynamic interaction between 4 different single doses of BIA 3-202 (50 mg…
- Trial name
- NCT02763839
- Testing
- BIA 3-202, Sinemet 25/100
- Where
- Portugal
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Healthy Volunteers, Health Promotion
Dance-Mindfulness Intervention for Well-Being in Recreational Adults
This 12-week study protocol outlines a randomized controlled trial designed to evaluate the effectiveness of a Dance-Mindfulness intervention integrating Modern Theatre Dance with mindfulness-based embodied practices to enhance…
- Trial name
- DanceMind (NCT07262177)
- Testing
- Dance-Mindfulness Intervention
- Where
- Greece
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Healthy
Pharmacokinetic and Safety Study of HYLENEX Recombinant-Augmented Subcutaneous Ceftriaxone Administration
The objectives of this study are: to establish the safety of subcutaneous administration of ceftriaxone at different concentrations, with and without HYLENEX recombinant, and to determine the maximum tolerated concentration; and…
- Trial name
- INFUSE-Cftrx (NCT00493220)
- Testing
- SC HYLENEX and Ceftriaxone, IV Ceftriaxone
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Healthy Subjects
Multiple Ascending Dose Study of CM338 in Healthy Volunteers
This study was a multi-center, randomized, double blind, placebo-controlled, single-dose, dose escalation Phase I study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of CM338 with…
- Trial name
- NCT05371379
- Testing
- CM338 Injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Healthy
Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways
In this study, the investigators will evaluate if the food intake associated with the infusion of erythromycin is caused by the phase 3 contractions or by another yet unknown effect of erythromycin.
- Trial name
- NCT02633579
- Testing
- erythromycin lactobionate, Atropine, Erythromycin with atropine
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteer
A Phase I Study of GFH312 in Healthy Chinese Subjects
The aim of this study was to evaluate the pharmacokinetic profile and observe the safety of GFH312 after single and multiple administrations in healthy Chinese subjects.
- Trial name
- NCT05991362
- Testing
- GFH312 100 mg, GFH312 200 mg, GFH312 120mg
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Zhejiang Genfleet Therapeutics Co., Ltd.
Healthy Volunteers
Study to Assess Absolute Bioavailability of TAK-935 (OV935) and to Characterize Mass Balance, Pharmacokinetics, Metabolism, and Excretion of [14C]TAK-935 (OV935) in Healthy Male Participants
The purpose of this study is to determine absolute bioavailability (ABA) of TAK-935 (F) following a single microdose intravenous (IV) administration of 50 microgram (μg) (approximately 1 microcurie [μCi]) [14C]TAK-935 and a…
- Trial name
- NCT04992442
- Testing
- TAK-935 Oral Tablet, [14C]TAK-935 IV Infusion, [14C]TAK-935 Oral Solution
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy Volunteers, Bacterial Infections
Safety, Tolerability, Pharmacokinetics of Intravenous RPX7009 in Healthy Adult Subjects
RPX7009 (beta-lactamase inhibitor) is being studies in combination with a carbapenem biapenem to treat bacterial infections, including those due to multi-drug resistant bacteria.
- Trial name
- NCT01751269
- Testing
- RPX7009
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Healthy
Next-Day Residual Effects of Gabapentin, Diphenhydramine and Triazolam on Simulated Driving Performance in Normal Volunteers
This study will examine the next-day residual effects of a nighttime dose of gabapentin 250 mg, diphenhydramine citrate 76 mg and triazolam 0.5 mg compared to placebo and each other on simulated driving performance in normal…
- Trial name
- NCT01888497
- Testing
- Gabapentin, Diphenhydramine citrate, Triazolam
- Where
- 4 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy Adults
Susceptibility of Human Volunteers With Different Histo-Blood With Different Histo-Blood Group Antigens to Norovirus
Objectives: To evaluate the role of human histo-blood group antigens in susceptibility to Norovirus infections. Description of Study Design: Healthy volunteers with different blood types and low antibody titers to the challenge…
- Trial name
- NCT01322503
- Testing
- Norovirus
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Healthy
Assessment of Exposure of BI 409306 in Cerebrospinal Fluid (CSF) Relative to Plasma as Well as to Evaluation of the Effect of Different Doses of BI 409306 on the cGMP (Cyclic Guanosine Monophosphate) Levels in CSF in Healthy Male Volunteers
Due to the exploratory nature of this trial, there is no primary objective in a confirmatory sense. The study aims to evaluate the effect of different doses of BI 409306 on biomarker and to assess the exposure of BI 409306
- Trial name
- NCT01493570
- Testing
- BI 409306
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
A Study of Carbon-14-Labeled LY2835219 ([^14C]-LY2835219) in Healthy Participants
This type of study is called a radiolabeled study. For this study, LY2835219 (study drug) has been specially prepared to contain radiolabeled carbon [^14C]. [^14C] is a naturally occurring radioactive form of the element carbon.
- Trial name
- NCT01913314
- Testing
- [^14C]-LY2835219
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
RTA 408 Lotion in Healthy Volunteers
This study is a first-in-human study of a topical dermal lotion formulation of RTA 408, a novel small molecule which suppresses oxidative stress and inflammation.
- Trial name
- NCT02029716
- Testing
- RTA 408 Lotion 0.5%, 1%, 3%
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Biogen