Clinical trials: Vital Pulp Therapy, open to volunteers
Pulpal Inflammation
Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental Care
Background: Vital pulp therapy (VPT) is a cornerstone of minimally invasive dentistry and aims to preserve pulp vitality whenever clinically feasible.
- Trial name
- INFLAPULP (NCT07533396)
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulptomy, Dental Caries
Effect of Ferric Sulphate and Putty MTA as Pulpotomy Agent in Vital Primary Teeth
The pulp in primary teeth has a high potential for repair because of high degree of cellularity and vascularity. The rationale for the pulpotomy procedure is that the radicular pulp tissue is healthy and capable of healing after…
- Conditions
- Pulptomy, Dental Caries, Pulp Therapy
- Trial name
- CT (NCT07324928)
- Testing
- Ferric sulphate, Putty MTA
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Jazan
Post-operative Pain, Vital Pulp Therapy
Compare the Impact of Sodium Hypochlorite and Saline Irrigation Protocols With and Without Cryotherapy on Post-operative Pain Following Pulpotomy in Permanent Mandibular Molar Teeth.
The aim of the present study will compare the impact of sodium hypochlorite and saline irrigation protocols with and without cryotherapy on post-operative pain following pulpotomy in permanent mandibular molar teeth.Will the use…
- Trial name
- NaOCl/VPT/MTA (NCT07764666)
- Testing
- VPT /pulpotomy, VPT/complete pulpotomy, vital pulp therapy /complete pulpotomy
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abdelrahman Refaat Khalaf Ahmed
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pulp Disease, Dental, Pulpitis
Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker
This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent…
- Conditions
- Pulp Disease, Dental, Pulpitis, Reversible Pulpitis, Irreversible Pulpitis (Toothache)
- Trial name
- NCT07452614
- Testing
- vital pulp treatment
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abeer Ghalib Abdul-khaliq
MTA Vital Tooth Pulpotomy
Clinical & Radiographic Efficacy Using LLLT & CRYO on M.P.M Pulpotomy
This in-vivo study aims to evaluate the efficacy of the low level laser therapy and cryotherapy in treatment of vital pulpotomy in mature permanent molar evaluating the post operative pain and the radiographic changes in pulpal…
- Trial name
- NCT06711081
- Testing
- low level laser device cryotherapy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Vital Pulp Therapies, Pulpotomy
Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars
The purpose of this RCT is to compare the clinical/radiographic outcomes of Potassium nitrate in polycarboxylate cement and MTA as pulpotomy biomaterials used for asymptomatic vital primary lower second molar and this will help…
- Conditions
- Vital Pulp Therapies, Pulpotomy, Pulp Disease, Dental, Pulpotomies Primary Teeth
- Trial name
- NCT06871709
- Testing
- Potassium Nitrate in Polycarboxylate cement, MTA-Anglus
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain, Vital Pulp Therapies
Impact of Sodium Hypochlorite Irrigation at Different Concentrations, With and Without Cryotherapy, on Post Operative Pain in Permanent Mandibular Molar Teeth.
The aim of the present study will compare the impact of sodium hypochlorite irrigation at different concentrations with and without cryotherapy on post operative pain in permanent mandibular molar teeth.
- Trial name
- VPT-RCT-MTA (NCT07771816)
- Testing
- vital pulp therapy
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Symptomatic Irreversible Pulpitis and Post Operative Pain
Laser-Assisted vs Conventional Total Pulpotomy in Symptomatic Irreversible Pulpitis
his randomized controlled clinical trial will compare laser-assisted total pulpotomy with conventional total pulpotomy in permanent molar teeth diagnosed with symptomatic irreversible pulpitis.
- Trial name
- LASERPULP (NCT07850258)
- Testing
- Conventional Total Pulpotomy, Laser-Assisted Total Pulpotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- meliksahgunduz
Post-operative Pain, Pulpitis - Irreversible
Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis
The aim of this study is to evaluate the clinical effectiveness of total pulpotomy (TP), radicular pulpotomy (RP), and root canal treatment (RCT) in mandibular premolar and/or molar teeth diagnosed with symptomatic irreversible…
- Conditions
- Post-operative Pain, Pulpitis - Irreversible, Success Rate
- Trial name
- NCT07375576
- Testing
- Total Pulpotomy, Radicular pulpotomy, Root canal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Pulp Disease, Dental, Pulp Therapy in Primary Molars
Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars
This study aims to evaluate clinical and radiographic success of oxymetazoline versus sodium hypochlorite as hemostatic agents in MTA pulpotomy of primary molars.
- Conditions
- Pulp Disease, Dental, Pulp Therapy in Primary Molars, Pulpitis - Reversible, Pulp Inflammation
- Trial name
- OXY - MTA (NCT07675330)
- Testing
- Oxymetazoline 0.05% nasal solution, Sodium Hypochlorite Solution
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Vital Pulp Therapies
Direct Pulp Capping Versus Pulpotomy for Primary Molars
Dental caries is one of the most prevalent chronic diseases worldwide. Interventions for treating deep carious lesions in teeth with no history of pain or teeth with reversible pulpitis are referred to as vital pulp therapy…
- Trial name
- MTA (NCT06973057)
- Testing
- Pulpotomy, Direct pulp capping (DPC)
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Deep Caries in Primary Molars
Clinical and Radiographic Assessment of Neo Putty MTA Versus Formocresol Used in Vital Pulpotomy of Mandibular Primary Molars
This randomized clinical trial aims to evaluate the clinical and radiographic success of NeoPutty MTA compared to formocresol in vital pulpotomy of mandibular primary molars in children aged 4 to 9 years.
- Trial name
- NCT07437794
- Testing
- NeoPutty MTA, Formocresol
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- October University for Modern Sciences and Arts
Deep Caries, Pulpitis Reversible
The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious Tissue
The goal of this prospective, observational clinical cohort study is to study the effect of the preoperative condition of the tooth on the outcome of partial removal of carious tissue in mature teeth in adults.
- Conditions
- Deep Caries, Pulpitis Reversible, Pulp Hyperemia
- Trial name
- NCT05816525
- Testing
- Partial removal of carious tissue, Final restoration
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Irreversible Pulpitis
Comparative Effectiveness in the Management of Irreversible Pulpitis
This project addresses a central question within the practice of dentistry: Is a pulpotomy procedure effective in the treatment of a tooth with symptomatic irreversible pulpitis and normal periapex? In addition, the project seeks…
- Trial name
- NCT04922229
- Testing
- RCT, Pulpotomy
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Vital Pulp Therapy
Age-Related Inflammatory Proteins as Indicators of Vital Pulp Therapy Outcomes
Predicting the success of vital pulp therapy remains a clinical challenge. There is a knowledge gap regarding the relationship between age, inflammasome related proteins expression , and clinical/radiographic outcomes.
- Trial name
- NCT07893977
- Testing
- Standardized complete pulpotomy protocol
- Volunteers
- 75 people
- Sponsor
- Cairo University
Deep Dentin Caries in Mature Permanent Teeth
Partial Pulpotomy vs Selective Removing in Deep Caries
The aim of this study was to compare the one-year results of selective caries removal and partial pulpotomy treatments in terms of pulp survival and the need for further endodontic treatment in deep carious lesions.Individuals…
- Trial name
- NCT07120009
- Testing
- selective caries removal, partial pulpotpmy
- Volunteers
- 70 people
- Sponsor
- Cukurova University
Pulpitis - Irreversible
Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
This study is a randomised controlled trial for complete pulpotomy as an alternative to root canal treatment for teeth with clinical diagnosis of symptomatic irreversible pulpitis (i.e.
- Trial name
- NCT05964933
- Testing
- Complete Pulpotomy, Pulpectomy and Root Canal Treatment
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Primary Teeth Indicated for Pulp Therapy
Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques
The null hypothesis of the current study suggested that there will be no significant difference regarding the effect of Graphene Oxide (GO), Lesion sterilization and tissue repair (LSTR) and Zinc Oxide and Eugenol on the clinical…
- Trial name
- NCT07424053
- Testing
- Graphene Oxide using vital pulpotomy technique, MTA using vital pulpotomy technique, Zinc Oxide and Eugenol using vital pulpotomy technique
- Volunteers
- 126 people
- Sponsor
- Al-Azhar University
Irreversible Pulpitis (toothache)
Garlic Oil As Root Filling Material in Primary Molars
The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.
- Trial name
- NCT06755502
- Testing
- Garlic oil, Calcium Hydroxide, Iodoform, paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University