Clinical trials: Visual Suppression
Postoperative Delirium
Association Between Burst Suppression During Anesthetic Induction With Postoperative Delirium in Cardiac Surgery
The population over 65 years of age will be increasingly exposed to surgical procedures that require general anesthesia. Postoperative delirium is one of the main causes of preventable postoperative morbidity in the elderly…
- Trial name
- NCT04713644
- Testing
- Standardized Propofol Administration
- Where
- Chile
- Volunteers
- 78 people
- Sponsor
- Pontificia Universidad Catolica de Chile
HIV
City-Wide Implementation and Evaluation of the B-OK Bottles for HIV Treatment Adherence Support in the Philadelphia Ryan White Medical Case Management Network
The researchers will conduct a hybrid implementation-effectiveness study of a city-wide B-OK rollout led by PDPH with research and evaluation support from the University of Pennsylvania.
- Trial name
- B-OK PDPH (NCT07807137)
- Testing
- B-OK Bead Bottles
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Breast Cancer, Quality of Life
RWE About QOL and Compliance of Patients With OFS in China
The purpose of this study is to assess the patient's feedback from using GnRHa depot formulation in postoperative, premenopausal patients with hormone receptor-positive breast cancer.
- Conditions
- Breast Cancer, Quality of Life, Hormone Receptor-positive Breast Cancer
- Trial name
- NCT05122377
- Testing
- 3M GnRHa, 1M GnRHa
- Where
- China
- Volunteers
- 562 people
- Sponsor
- Fudan University
Healthy Subjects, Obesity
Glucagon Modulation of Ghrelin Secretion
As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo. It is well known that intramuscular glucagon administration stimulates growth hormone (GH)…
- Conditions
- Healthy Subjects, Obesity, Diabetes Mellitus, Type 1
- Trial name
- NCT00929812
- Testing
- Glucagon hydrochloride (GlucaGen®), NaCl 0.9%
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
HIV
Planning for SUCCESS
Planning for SUCCESS (Sustained, Unbroken Connections to Care, Entry Services, and Suppression) is a project to improve the connection to community care for HIV infected persons leaving Fulton County Jail or Atlanta City…
- Trial name
- SUCCESS (NCT02185742)
- Testing
- Strength Based Case Management
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Emory University
HIV, HIV Infections
A Study to Evaluate Efficacy, Safety and Tolerability in Antiretroviral Therapy (ART)-Experienced Participants of at Least 50 Years of Age Living With Human Immunodeficiency Virus (HIV) With Virologic Suppression Who Switch to DTG/3TC FDC From BIC/FTC/TAF
The study aims at evaluating the maintenance of virologic suppression of dolutegravir/lamivudine (DTG/3TC) fixed dose combination (FDC) at Week 48 post-switch from bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in…
- Trial name
- EYEWITNESS (NCT05911360)
- Testing
- DTG/3TC
- Where
- 56 sites in United States, Austria and 10 more
- Volunteers
- 205 people
- Sponsor
- ViiV Healthcare
Acute Lymphoblastic Leukemia, Burkitt Lymphoma
Adoptive TReg Cell for Suppression of aGVHD After UCB HSCT for Heme Malignancies
This is a single center pilot study of a non-myeloablative umbilical cord blood transplant for the treatment of a hematological malignancy with a single infusion of T regulatory (Treg) given shortly after UCB transplantation.
- Conditions
- Acute Lymphoblastic Leukemia, Burkitt Lymphoma, Natural Killer Cell Malignancies, Chronic Myelogenous Leukemia
- Trial name
- NCT02991898
- Testing
- Infusion of Treg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Allergic Rhinitis, Asthma
Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline
Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms).
- Trial name
- GINA3 (NCT04202263)
- Testing
- Minocycline Topical
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- State University of New York - Downstate Medical Center
Cough Suppression, Thyroidectomy
Effects of Dexmedetomidine Combined With Lidocaine Topical Administration on Cough Reflex During Extubation in Thyroidectomy Patient.
Study Hypothesis: The combination of dexmedetomidine and lidocaine administered as laryngopharyngeal topical spray provides superior suppression of extubation cough reflex compared to lidocaine alone or placebo, without…
- Trial name
- NCT07832214
- Testing
- · Dex-Lido solution: Dexmedetomidine 100 μg/mL (concentration) was diluted with 2% lidocaine to achieve final concentration of dexmedetomidine 1 μg/kg in 5 mL total volume, · Lido solution: 2% lidocaine, 5 mL, · Control solution: 0.9% normal saline, 5 mL
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Lung Cancer (Diagnosis), Sarcoidosis
Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease
This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD).
- Conditions
- Lung Cancer (Diagnosis), Sarcoidosis, Chronic Obstructive Pulmonary Disease, Immunotherapy Resistance
- Trial name
- IMMUNOPUMON2 (NCT07384897)
- Testing
- Peripheral Blood Collection for Immune Profiling
- Where
- Belgium
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Pediatric, Sedation
Nebulized Dexmedetomidine as a Premedication for Gastrointestinal Endoscopy in Pediatric Patients
This study aims to demonstrate that the application of nebulized dexmedetomidine to patients during pediatric upper gastrointestinal endoscopic procedures will significantly reduce the gag reflex and enhance both patient and…
- Trial name
- NCT06218797
- Testing
- a routine sedation protocol, Nebulized with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ondokuz Mayıs University
Energy Intake
Glycogen and Appetite
Obesity is the outcome of chronic excessive energy intake and reduced energy expenditure leading to energy imbalance. It is a risk factor for many preventable diseases such as metabolic disease and its consequences such as type 2…
- Trial name
- NCT05417659
- Testing
- Exercise plus carbohydrate, Exercise plus niacin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Bath
Parkinson's Disease
Development of Parkinson's Glove for Detection and Suppression of Hand Tremor
This study is aimed to study the feasibility and safety of parkinson's glove that combined 2 module of tremor detection and tremor suppression with electrical muscle stimulation for using as device for rest tremor suppression in…
- Trial name
- NCT02370134
- Testing
- Parkinson's glove
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
Hemangioma
Immune Suppression Of Infants Treated With Steroids
The goal of this study is to clarify the degree of immune suppression in infants requiring therapy and to create guidelines for evaluation and prevention of infection in infants on oral steroids for hemangiomas.
- Trial name
- NCT00433940
- Testing
- Prednisolone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical College of Wisconsin
Peptic Ulcer
Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer
The purpose of this study is to compare the gastric acid suppression profile among different regimen (Oral Vs Intravenous)of administration of proton pump inhibitor - Esomeprazole by 24hours intragastric pH monitoring.
- Trial name
- NPH (NCT00471029)
- Testing
- esomeprazole
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital
HIV Infections
Evaluation of Atazanavir Substitution Intervention (EASI) Study
With the advent of highly active antiretroviral therapy (HAART), it was hypothesized that its consistent use could lead to a cure for HIV infection in as little as three years [Perelson, 1997].
- Trial name
- NCT00247845
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Healthy, Men
Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men
This is a Phase IIa multicenter, double-blind, placebo-controlled study in healthy men to evaluate the spermatogenesis suppression after oral administration of Dimethandrolone Undecanoate (DMAU) alone or with Levonorgestrel (LNG)…
- Conditions
- Healthy, Men, Male Contraception
- Trial name
- NCT03455075
- Testing
- Dimethandrolone-Undecanoate, Levonorgestrel 0.03 MG
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Premier Research
End-Stage Kidney Disease
The Effect of Mindfulness on Emotional Regulations Skills and Quality of Life Among Patients on Hemodialysis
The study aims to investigate how mindfulness-based intervention (MBI) impacts trait mindfulness, cognitive reappraisal, expressive suppression and quality of life in patients with end-stage renal disease (ESRD) undergoing…
- Trial name
- NCT06622200
- Testing
- Mindfulness-based Intervention
- Where
- Jordan
- Volunteers
- 120 people
- Sponsor
- Jordan University of Science and Technology
Critical Illness, Sepsis
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
Despite the introduction of multiple preventative measures rates of hospital acquired infection in the intensive care unit remain high. New approaches to tackling this problem are required.
- Conditions
- Critical Illness, Sepsis, Immuno-suppression
- Trial name
- GMCSF (NCT01653665)
- Testing
- Leukine, Normal Saline
- Where
- 4 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Androgen Axis Suppression, Prostatectomy
PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.
1. Personalize treatment for prostate cancer based on how aggressive the disease is and 2. Learn if apalutamide-based treatment can help to reduce fatigue and other side effects of treatment in participants who are being treated…
- Conditions
- Androgen Axis Suppression, Prostatectomy, Prostate Cancer
- Trial name
- NCT06274047
- Testing
- Apalutamide, Androgen Deprivation Therapy
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center