Clinical trials: Visual Impairments
Dry Eye, Vision; Disturbance, Hysterical
The Influences of Dry Eye Disease on Optical Quality
DED could result in visual disturbance and damage optical quality. We aimed to evaluate the influences of dry eye disease (DED) on optical quality and their correlations.
- Trial name
- NCT04043949
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking University Third Hospital
Neurological Disorder
Cross Education in Patients With Sensorimotor Impairment
The purpose of this study is to investigate the effects of training of the non-involved upper limb on the motor ability of the hemiparetic upper limb in patients with unilateral sensorimotor motor impairments.
- Trial name
- NCT02795507
- Testing
- Rehabit-Tec System, conventional exercises
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Nachum Soroker, MD
Stroke, Ischemic, Stroke Hemorrhagic
Radial Extracorporeal Shock Wave Therapy and Visual Feedback Balance Training on Lower Limb Post-Stroke Spasticity, Trunk Performance and Balance:
This study assess the relationship between lower limb spasticity and trunk movements during static and dynamic balance in post-stroke patients who also underwent conventional physical therapy, visual feedback balance training and…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke, Spastic Gait
- Trial name
- NCT05196633
- Testing
- radial extracorporeal shock wave therapy
- Where
- Romania
- Volunteers
- 23 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Central Visual Impairment
Training Oculo-motor Control to Improve Vision When Using a Preferred Retinal Locus
When high-detail vision is lost due to a retinal disease such as macular degeneration, people see poorly, and have difficulty with eye movements (oculo-motor control).
- Trial name
- NCT05637385
- Testing
- Training of perception and oculo-motor control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Russell L. Woods
Retinitis Pigmentosa, Usher Syndrome Type 2
Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)
The purpose of this study is to evaluate the efficacy safety and tolerability of QR-421a administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene with…
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Deaf Blind, Retinal Disease
- Trial name
- NCT05176717
- Testing
- QR-421a
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 5 people
- Sponsor
- Laboratoires Thea
Central Retinal Vein Occlusion
Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Central Retinal Vein Occlusion (CRVO)
Provide efficacy and safety data on intravitreal injections of ranibizumab 0.5 mg in patients with visual impairment due to macular edema secondary to CRVO
- Trial name
- Camellia (NCT01976312)
- Testing
- Ranibizumab 0.5 mg
- Where
- 34 sites in China, Hong Kong and 5 more
- Volunteers
- 252 people
- Sponsor
- Novartis Pharmaceuticals
Depression in Old Age, Ketamine
Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment.
the prevalence of depression in elderly is from 4 to 30% and is associated with a lower quality of life mayor medical comorbidity, and increased mortality.
- Trial name
- NCT03473431
- Testing
- Ketamine, control
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Retinitis Pigmentosa
Evoked Retinal Response
Retinitis pigmentosa (RP) is the name given to a group of inherited eye diseases that affect the retina (the light-sensitive part of the eye).
- Trial name
- NCT01415453
- Testing
- Ultrasound Stimulus
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Visual Impairment, Macular Edema
Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Branch Retinal Vein Occlusion (BRVO)
This clinical trial is designed to compare ranibizumab in comparison with Dexamethasone implant after 6 months of treatment. In the study arm Ranibizumab will be given monthly in a pro re nata scheme whereas the comparator…
- Conditions
- Visual Impairment, Macular Edema, Branch Retinal Vein Occlusion
- Trial name
- COMRADE-B (NCT01396057)
- Testing
- Ranibizumab, Dexamethasone Implant
- Where
- 66 sites in Czechia, Germany and 3 more
- Volunteers
- 244 people
- Sponsor
- Novartis Pharmaceuticals
Stroke Induced Vision Loss, Hemianopia
Visual Restoration for Hemianopia
The purpose of this research is to assess the efficacy of a visual training task on reducing the size of a visual field deficit caused by brain damage in adults, and its ability to improve visual functions in this patient…
- Conditions
- Stroke Induced Vision Loss, Hemianopia, Quadrantanopia
- Trial name
- NCT03350919
- Testing
- Training in the blind field, Training in the intact field
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Rochester
Dim Light Vision Disturbances
Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances
The objectives of this study are: To evaluate the efficacy of Nyxol to improve mesopic low contrast visual acuity (mLCVA) in subjects with Dim Light Vision Disturbances (DLD) To evaluate efficacy of Nyxol to improve visual…
- Trial name
- NCT04638660
- Testing
- Phentolamine Ophthalmic Solution 0.75%
- Where
- 17 sites in United States
- Volunteers
- 144 people
- Sponsor
- Opus Genetics, Inc
Visual Impairment in Children
Highlighting the Benefits of a Screening Protocol Delivered by Orthoptists to Identify Visual Impairment in Children Aged 3 to 4
Visual developmental abnormalities affect 10 to 15% of the population under 6 years of age and leads to amblyopia in 30% of cases if left untreated.
- Trial name
- ORTHOPHTALMO (NCT04395560)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Clinique Rive Gauche
Macular Edema, Retinal Vein Occlusion
A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept, in participants with macular edema due to treatment-naïve branch (BRVO) or central retinal vein occlusion (CRVO).
- Trial name
- BEACON (NCT04592419)
- Testing
- KSI-301, Aflibercept
- Where
- 141 sites in United States, Czechia and 10 more
- Volunteers
- 568 people
- Sponsor
- Kodiak Sciences Inc
Diabetic Macular Edema
To Compare Brolucizumab to Aflibercept in Chinese Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of Chinese patients with visual impairment due to Diabetic Macular Edema.
- Trial name
- KINGLET (NCT04058067)
- Testing
- Brolucizumab, Aflibercept
- Where
- 24 sites in China
- Volunteers
- 266 people
- Sponsor
- Novartis Pharmaceuticals
Endothelial Dysfunction, Sublingual Capillary Glycocalyx and Density
Prematurity as Predictor of Children's Cardiovascular-renal Health
Extreme preterm birth interferes with the development of the cardiovascular system. Both macro- as well as microvasculature undergoes extensive, organ specific maturation.
- Conditions
- Endothelial Dysfunction, Sublingual Capillary Glycocalyx and Density, Visual Disturbances and Blindness, Ventricular Dysfunction, Left
- Trial name
- PREMATCH (NCT02147457)
- Where
- Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Age Related Macular Degeneration
Study of WA-NG Telescope Prosthesis in Patients With End-stage Age-related Macular Degeneration
This is a pilot study to evaluate the safety of the Model WA-NG telescope prosthesis in patients with bilateral moderate to profound central vision impairment due to end-stage age-related macular degeneration.
- Trial name
- NCT01361256
- Testing
- Telescope prosthesis, WA-NG Telescope Prothesis
- Where
- Israel
- Sponsor
- VisionCare, Inc.
Visual Rehabilitation, Oddball Design
In-person and Telehealth Visual Rehabilitation for Children With Low Vision
Restorative visual rehabilitation is frequently used to enhance the visual development and function of children with low vision.
- Conditions
- Visual Rehabilitation, Oddball Design, Cerebral Visual Impairment, Passive Visual Stimulation
- Trial name
- NCT06701617
- Testing
- restorative visual rehabitation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Schizoaffective Disorder
NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia
This study will examine brain metabolic and excitatory/inhibitory mechanisms related to cognitive and visual functioning in adults with schizophrenia and healthy control participants.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Impairment, Visual Impairment
- Trial name
- NCT07788755
- Testing
- Perceptual Discrimination Training, Cognitive Control Training
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Visual Impairment
MRI Screening for Auditory Pathway Malformations in Visually Impaired Children
This pilot study aims to assess the interest to add an auditory pathway morphological analysis during the MRI exploration of visual pathway in visually impaired children.
- Trial name
- DIMAVE (NCT02896738)
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cerebral Palsy
Investigation of Relations Between Edinburgh Visual Gait Score and Selective Motor Control for Children With CP
Children with Cerebral Palsy have generally limited selective motor control which affects their ability to complete functional tasks Selective Motor Control has been shown to correlate with specific characteristics of gait…
- Trial name
- NCT04686630
- Testing
- Video based observational gait analysis and SCALE Test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Yeditepe University