Clinical trials: Visual Acuity
Visual Acuity
Evaluation of Dryness in a Silicone Hydrogel Daily Disposable Contact Lens
This is a multi-site, randomized, bilateral, dispensing, parallel design study with two arms to evaluate contact lens related dry eye symptoms and subjective comfort.
- Trial name
- NCT04849780
- Testing
- ACUVUE Oasys 1-Day, Habitual Lens
- Where
- 9 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity
Role of Glare and Spectral Filtering on Contrast Sensitivity: A Pilot Study
This will be a split-plot design, randomized, parallel, double-masked feasibility study to evaluate the role of a test lens on contrast sensitivity with and without glare.
- Trial name
- NCT05582304
- Testing
- Test Lens, Control Lens
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Diabetes Mellitus, Macular Edema
Intravitreal Aflibercept Injection in Vision Impairment Due to DME
To determine the efficacy of intravitreally (IVT) administered VEGF Trap-Eye on the best-corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS) chart in subjects with diabetic macular…
- Trial name
- VIVID-DME (NCT01331681)
- Testing
- VEGF Trap-Eye (BAY86-5321), Macular Laser Photocoagulation (Control)
- Where
- 73 sites in Australia, Austria and 9 more
- Volunteers
- 406 people
- Sponsor
- Bayer
Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
Visual Outcome in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV) Treated With Either Ranibizumab as Monotherapy or Combined With Verteporfin Photodynamic Therapy (vPDT)
This study compared the effect of ranibizumab administered as monotherapy versus ranibizumab administered in combination with verteporfin photodynamic therapy (PDT) on visual acuity in patients with symptomatic macular polypoidal…
- Trial name
- EVEREST II (NCT01846273)
- Testing
- Ranibizumab, Verteporfin PDT
- Where
- 41 sites in Hong Kong, Japan and 5 more
- Volunteers
- 321 people
- Sponsor
- Novartis Pharmaceuticals
Dry Age-related Macular Degeneration
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE III)
This LIGHTSITE III study is a double-masked, sham-controlled, parallel design, prospective multi-site study for the use of PBM as a treatment for visual impairment in subjects with dry AMD.
- Trial name
- NCT04065490
- Testing
- Valeda Light Delivery System
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- LumiThera, Inc.
Visual Acuity
Evaluation of Investigational Daily Disposable Multifocal Contact Lenses Produced With Different Manufacturing Processes in Myopes
This is a single-masked, 2×3 crossover, randomized controlled, dispensing clinical trial to evaluate the visual performance (logMAR) and subjective vision responses of the Test Lens.
- Trial name
- NCT04889625
- Testing
- senofilcon A C3, Dailies Total 1® Multifocal Contact Lenses
- Where
- 6 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Visual Acuity
Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of Investigational Lubricating Eye Drops
This will be a single-visit, multi-site, randomized, single-masked, bilateral, active-controlled, non-dispensing, 2X2 crossover study.
- Trial name
- NCT05814367
- Testing
- Blink® Tears eye drops in a multidose bottle, Preservative-free investigational lubricating eye drops in a Novelia® eyedropper
- Where
- 3 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity
Evaluation of a Daily Disposable Novel Multifocal Contact Lens in a Myopic Population; Part 2
This is a 6-visit, subject-masked, multi-site, 2×3 crossover dispensing trial that will last approximately 2 - 4 months.
- Trial name
- NCT04615507
- Testing
- JJVC Investigational Multifocal Contact Lens, Dailies Total 1® Multifocal Contact Lens
- Where
- 6 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity
Clinical Comparison of Two Marketed Reusable Cosmetic Contact Lenses
This will be a 4-visit, multi-site, randomized, brand-masked, bilateral, 2×2 crossover study. If a subject is found to meet all eligibility criteria, they will be randomized to one of two lens wear sequences.
- Trial name
- NCT03755882
- Testing
- ACUVUE® DEFINE™ Vivid Style, LACELLE™ Sparkling Brown
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Presbyopia
Safety and Effectiveness Study of the AcuFocus Corneal Inlay ACI 7000PDT in Presbyopes
The purpose of this study is to determine if the AcuFocus Corneal Inlay ACI 7000PDT will provide an effective method for the correction of presbyopia in patients who have normal distance vision but need a correction such as…
- Trial name
- ACI (NCT00850031)
- Testing
- AcuFocus Corneal Inlay
- Where
- 8 sites in Australia, Austria and 4 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- AcuFocus, Inc.
Visual Acuity
Characterizing Successful Myopic Multifocal Contact Lens Wearers
This will be a prospective, single group, single-arm, and bilateral dispensing study. Subjects will be assigned to a single study lens type to be worn bilaterally in daily wear, and daily disposable modality, for at least 6 hours…
- Trial name
- NCT04178772
- Testing
- Acuvue Moist Multifocal Contact Lens JJVC Marketed Contact Lens
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye, Eye Strain
Effects of Gunnar Computer Glasses on Viewing Comfort and Performance
The proposed study aims to test if Gunnar computer glasses provide any advantages, in comparison to no glasses, on the following aspects in computer-related office work: Any enhancement on the visual performance of the basic…
- Conditions
- Dry Eye, Eye Strain, Visual Acuity, Color Perception
- Trial name
- NCT02925884
- Testing
- Gunnar OTC Glasses
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pacific University
Symptomatic Vitreomacular Adhesion
A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion
The purpose of this study is to evaluate the superiority regarding vitreomacular adhesion (VMA) resolution of a single intravitreal injection of A01016 (Ocriplasmin) compared to sham-injection in subjects with symptomatic VMA.
- Trial name
- NCT01889251
- Testing
- Ocriplasmin
- Where
- Japan
- Volunteers
- 251 people
- Sponsor
- Alcon Research
Visual Acuity
Clinical Evaluation of Senofilcon A Contact Lenses Using a Novel Manufacturing Technology
This study is a multi-site, randomized, double-masked, 2×2 crossover design, 1-week dispensing study. Subjects will wear bilaterally both Test and Control lenses in a random order for 1-week each as a daily disposable modality…
- Trial name
- NCT04531241
- Testing
- ACUVUE® OASYS 1-DAY
- Where
- 7 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity
An Investigation of the Impact of Localized Topical Anesthesia of the Ocular Surface on End-of-day Contact Lens Discomfort
This is a controlled, randomized, subject-masked, 3x3 crossover, non-dispensing, contralateral study. Twenty subjects will be recruited based on their scores (with their habitual lenses) from the Contact Lens Dry Eye…
- Trial name
- NCT03733899
- Testing
- Local Anesthesia
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity, Geographic Atrophy
A Study to Evaluate the Safety and Clinical Response of Subretinal Administration of CNTO 2476 in Participants With Geographic Atrophy
The purpose of this study is to evaluate the safety and performance profile of the suprachoroidal surgical approach and the Delivery System.
- Conditions
- Visual Acuity, Geographic Atrophy, Macular Degeneration
- Trial name
- PRELUDE (NCT02659098)
- Testing
- CNTO 2476 3.0 x 10^5 cells, Subretinal Delivery System
- Where
- 8 sites in United States
- Volunteers
- 21 people
- Sponsor
- Janssen Research & Development, LLC
Visual Acuity
Clinical Evaluation of Investigational Contact Lenses
Single-visit, unmasked, non-dispensing study where subjects will wear three different lenses bilaterally in one visit, each lens being worn for approximately 30-60 minutes.
- Trial name
- NCT02801396
- Testing
- Etafilcon A Design 1 (Test 1), Etafilcon A Design 2 (Test 2), Etafilcon A (Control)
- Where
- Hong Kong
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Retinal Vein Occlusion
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)
To determine the efficacy of vascular endothelial growth factor (VEGF) Trap-Eye injected into the eye on vision function in subjects with macular edema as a consequence of central retinal vein occlusion
- Trial name
- GALILEO (NCT01012973)
- Testing
- Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321)
- Where
- 73 sites in Australia, Austria and 8 more
- Volunteers
- 177 people
- Sponsor
- Bayer
Visual Acuity
Effects of Multifocal Contact Lens on Ocular Tissue
The purpose of this study is to evaluate the etafilcon - PVP (multi-focal)
- Trial name
- NCT02345720
- Testing
- etafilcon - PVP (multi-focal)
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.