Clinical trials: Vestibulodynia
Vulvodynia, Provoked Vestibulodynia
Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health
This trial will provide evidence for the effective management of pain and pain-related domains among those who experience provoked vestibulodynia (PVD) using photobiomodulation (PBM) and multimodal physiotherapy (mPT) in a…
- Conditions
- Vulvodynia, Provoked Vestibulodynia, Dyspareunia
- Trial name
- BRIGHT (NCT06660212)
- Testing
- Photobiomodulation, Multimodal physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
Vulvodynia
Enoxaparin as Treatment for Vulvodynia
The investigators hypothesize that injections of Low molecular weight heparin (LMWH) [enoxaparin] will reduce pain in women with vulvodynia.
- Trial name
- NCT00874484
- Testing
- Clexane (enoxaparin)
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Localized Provoked Vulvodynia
The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia
The proposed study will evaluate how personality characteristics, cognitive factors and the emotional and behavioral responses of patients with provoked vestibulodynia (localized provoked vulvodynia) influence the natural history…
- Trial name
- NCT02892214
- Testing
- Pelvic floor physical therapy, estriol cream (ovestin), Low-level-laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Lichen Sclerosus, Lichen Planus
Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis
The objective of the study was to determine sensitivity, specificity and diagnostic accuracy of "Three Rings Vulvoscopy" for detection of vulvar dermatosis using histopathology as the reference standard.
- Conditions
- Lichen Sclerosus, Lichen Planus, Lichen Simplex Chronicus, Vulvodynia
- Trial name
- DATRIV (NCT02732145)
- Testing
- "Three Rings Vulvoscopy" (TRIV), Histopathology
- Where
- Croatia
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Ginekološka Poliklinika Dr. Vesna Harni
Vestibulodynia
A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia
This study aims to assess the pain on contact in provoked vestibulodynia, measured with Visual Analogic Scale at week 0/week 2/week 6/week 12 after applying a patch of capsaicin.
- Trial name
- CAPSIVU (NCT02854670)
- Testing
- Capsaicin patch
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Provoked Vestibulodynia
Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia
Provoked vestibulodynia, previously called vulvar vestibulitis syndrome, is clinically defined as chronic, unexplained, vulvar pain or discomfort confined to the vulvar vestibule in response to contact or pressure.
- Trial name
- LLLT (NCT01149031)
- Testing
- LOW LEVEL LASER SYSTEM
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Provoked Vestibulodynia
Integrated Mindfulness for Provoked Vestibulodynia
This study aims to test the efficacy of a 4-session intervention (Group psychoeducational treatment) using a randomized study design. Participants will be randomized in to 'immediate treatment' or 'waitlist control'.
- Trial name
- IMPROVED (NCT01704443)
- Testing
- Group Psychoeducational Treatment, Waitlist control
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- University of British Columbia
Vulvar Diseases, Vulvar Pain
Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis
To evaluate the use of topical application of Nifedipine cream for the treatment of Provoked localized Vulvodynia (vestibulitis, vestibulodynia).
- Conditions
- Vulvar Diseases, Vulvar Pain, Vestibulitis, Vestibulodynia
- Trial name
- NCT00496184
- Testing
- Nifedipine cream topical application
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Western Galilee Hospital-Nahariya
Vestibulodynia
Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia
There have been reports in the medical literature demonstrating a link between the development of provoked vestibulodynia (PVD), a sexual pain disorder, and hormonal contraceptive (HC) use.
- Trial name
- NCT01741948
- Testing
- Hormonal contraceptive
- Where
- 2 sites in Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- ahinoam lev sagie
Vestibulodynia
Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia
Chronic gynaecological pain is a major medical problem that affects 20-30% of women at different moments of their life. This largely neglected issue has a significant impact on the sexual and conjugal life of women suffering from…
- Trial name
- NCT01455350
- Testing
- Multimodal physiotherapy, lidocaine
- Where
- 2 sites in Canada
- Volunteers
- 212 people
- Sponsor
- Université de Sherbrooke
Vestibulodynia (VBD), Vulvodynia
Vestibulodynia At High Resolution: Omics Approach to Improve Diagnosis
According to recent nomenclature, vulvodynia is vulvar pain without a clear identifiable cause persisting for at least 3-months and distinguished from vulvar pain caused by a specific disorder (inflammatory, neoplastic…
- Trial name
- NCT06865963
- Testing
- vulvar biopsy and blood semples
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Vulvar Vestibulitis
Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia
The purpose of the study was to compare the effectiveness of cognitive behavioural therapy (CBT) and physical therapy (PT) on pain and psychosexual outcomes in women with provoked vestibulodynia (PVD).
- Trial name
- NCT02494934
- Testing
- cognitive-behavioural therapy, physical therapy
- Volunteers
- 20 people
- Sponsor
- Queen's University
Provoked, Localized Vulvodynia, Provoked Vestibulodynia
Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study
The investigators research project is a randomized, controlled, single-blinded, feasibility pilot study. The investigators will study the feasibility of a novel treatment for women with Provoked Localized Vulvodynia (PLV) with…
- Conditions
- Provoked, Localized Vulvodynia, Provoked Vestibulodynia, Vulvar Vestibulitis, Vulvodynia
- Trial name
- NCT01996384
- Testing
- Classical Acupuncture, Non-classical acupuncture, Lidocaine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Oregon College of Oriental Medicine
Vestibulodynia
A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia
The main objective of this study is to compare the efficacy of botulinum toxin injections on vestibulodynia pain compared to a group treated with a placebo.
- Trial name
- VESTIBULE (NCT02858219)
- Testing
- Botulinum Toxin Type A, Saline solution, Indexes
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Vestibulodynia
Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia
Vulvodynia is a debilitating chronic vulvar pain lasting at least 3 months without a clear identifiable cause that is challenging to treat effectively.
- Trial name
- NCT03390049
- Testing
- Fractional CO2 Laser Treatment
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Vulvar Vestibulitis, Vulvar Diseases
Botox on Vulvar Vestibulitis
The study seeks to evaluate the effect of botulinum toxin on vulvar vestibulitis (VVS) after local injection with Botox, a potential treatment to relieve patients of vulvar pain, reducing the need for painkillers, and improving…
- Trial name
- NCT00119886
- Testing
- Botulinum toxin
- Where
- 2 sites in Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vulvodynia, Vulvodynia, Generalized
Effect of Two Acupuncture Protocols on Vulvodynia
Vulvodynia is a common condition in women (16%); however, at this time there is no known effective non-pharmacological therapy reported.
- Conditions
- Vulvodynia, Vulvodynia, Generalized, Vulvar Vestibulitis, Vulvar Pain
- Trial name
- Acu/Vul-pain (NCT03481621)
- Testing
- Acupuncture, Standard care
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- McLean Center for Complementary and Alternative Medicine, PLC
Vestibulodynia
Feasibility Study for Provoked Vestibulodynia
The feasibility and acceptability of a somatosensory rehabilitation program and an educational pain management program will be investigated in women with provoked vestibulodynia.
- Trial name
- NCT05342402
- Testing
- Somatosensory Rehabilitation Program, Educational Pain Management Program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Provoked Vestibulodynia
Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
This randomized trial, nicknamed the COMFORT (Cognitive therapy or Mindfulness FOR Treatment of pvd) study, will compare the effects of an 8-session group Mindfulness-based Cognitive Therapy (MBCT) to an 8-session group Cognitive…
- Trial name
- COMFORT (NCT01704456)
- Testing
- Mindfulness-based Cognitive Therapy, Cognitive Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- University of British Columbia
Vestibulodynia
Pilot Study to Assess the Efficacy of Cognitive-behavioral Couple Therapy for Provoked Vestibulodynia
The current pilot study aims to assess the feasibility and preliminary efficacy of a novel, 12-week targeted couple intervention (CBCT) for women with vulvodynia and their partners.
- Trial name
- NCT01582373
- Testing
- Cognitive-behavioral couple therapy
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Université de Montréal