Clinical trials: Vessel Disease
Congestive Heart Failure, Coronary Artery Disease
Autologous Cultured Myoblasts (BioWhittaker) Transplanted Via Myocardial Injection
MyoCell™ implantation by epicardial injection during CABG surgery has the potential to add a new dimension to the management of post-infarct deterioration of cardiac function.
- Conditions
- Congestive Heart Failure, Coronary Artery Disease, Myocardial Infarction
- Trial name
- NCT00050765
- Testing
- MyoCell™ Autologous Myoblasts
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Bioheart, Inc.
Multiple Myeloma
RMPT for Relapsed/Refractory Multiple Myeloma
After the discovery of melphalan and prednisone (MP), many clinical trials evaluated the efficacy of combination chemotherapy, such as VMCP, VBAP, MOCCA in multiple myeloma (MM) patients, without significant clinical benefit.
- Trial name
- RMPT (NCT00961467)
- Testing
- Revlimid, Melphalan, Prednisone, Thalidomide
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Fondazione EMN Italy Onlus
Acute Coronary Syndrome
PASSIvation of Vulnerable Plaque With AZD5718 in AcuTe Coronary syndromE
This is a multi-center study conducted at 8 sites in 2 countries (Singapore, New Zealand). Patients with an acute myocardial infarction (AMI) were randomized in a ratio of 1:1 ratio to receive AZD5718 (Atuliflapon) 125 mg or…
- Trial name
- PASSIVATE (NCT04601467)
- Testing
- AZD5718
- Where
- 8 sites in New Zealand, Singapore
- Volunteers
- 243 people
- Sponsor
- National University Heart Centre, Singapore
Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve
Identification of Genetic Causes of Calcific Aortic Valve Disease
This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
- Conditions
- Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification
- Trial name
- NCT04149600
- Testing
- Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Multiple Myeloma
C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET/CT
Positron emission tomography combined with computed tomography using carbon-11 acetate (ACT PET/CT) may help detect lesions before treatment and evaluate response following therapy in patients with from multiple myeloma (MM).
- Trial name
- ACTMM (NCT01691300)
- Testing
- ACT PET/CT
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Peripheral Arterial Disease
Hypoxic Exercise in Lower Extremity Artery Disease
The aim of this randomized controlled trial is to: Phase I: To explore, in a first pilot phase, the adequate combination of hypoxia severity and exercise intensity in patients with symptomatic lower extremity artery disease…
- Trial name
- NCT03506607
- Testing
- Exercise in hypoxia 1500m, Exercise in hypoxia 2500m, Exercise in normoxia
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
High Blood Pressure
Immediate Pressor Response to Oral Salt
The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)
- Trial name
- IPROS (NCT06226636)
- Testing
- salt
- Where
- 2 sites in Zambia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mulungushi University
Diabetic Foot, Diabetic Foot Ulcer
A Feasibility Study Comparing Usual Foot Education and Phone App Alerts in Patients With Increased Risk of Diabetic Foot
The purpose of this study is to compare foot care knowledge, behaviour and glycaemic control in patients at increased risk of diabetic foot ulcers.
- Trial name
- NCT03934944
- Testing
- Phone application, Usual care
- Where
- Kuwait
- Volunteers
- 100 people
- Sponsor
- Dasman Diabetes Institute
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Ulcerative Colitis, Myocardial Infarction
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI)
Inflammatory bowel diseases (IBD) are progressively increasing their prevalence worldwide. Up to half of patients may also have extraintestinal manifestation and cardiovascular diseases (CVDs) is one of the most relevant, being…
- Conditions
- Ulcerative Colitis, Myocardial Infarction, Stroke, Ischemic Heart Disease
- Trial name
- PROVACI (NCT07095634)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Intracranial Aneurysm
Efficacy and Safety of the Flow Diverter (Tonbridge) for Endovascular Treatment of Intracranial Aneurysms
The purpose of this study is to assess the efficacy and safety of the Flow Diverter (Tonbridge) for endovascular treatment of intracranial aneurysms.
- Trial name
- NCT04799964
- Testing
- Flow Diverter (Tonbridge), Tubridge (MicroPort)
- Where
- 13 sites in China
- Volunteers
- 187 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Hypertension
Evaluation of the Safety, Efficacy and Pharmacokinetics of MICARDIS® (Telmisartan) in Children and Adolescents With Hypertension
Study to assess the blood pressure lowering effects of two doses of telmisartan over a four-week treatment period; to determine potentially effective doses for pediatric patients for future studies; to assess the safety and…
- Trial name
- NCT02242344
- Testing
- Telmisartan
- Volunteers
- 77 people
- Sponsor
- Boehringer Ingelheim
Coronary Artery Disease
Latin America Real World Study With Inspiron Drug Eluting Stent - INSPIRON LATITUDE
Prospective, multicenter, single arm registry to monitor post-market clinical outcomes of patients treated with Inspiron Sirolimus-Eluting Stent with Biodegradable Polymer.
- Trial name
- LATITUDE (NCT03471234)
- Testing
- Angioplasty
- Where
- 2 sites in Brazil
- Volunteers
- 299 people
- Sponsor
- Scitech Produtos Medicos SA
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
COVID-19, Endothelial Dysfunction
The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05185934
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Carotid Artery Plaque
Photoacoustic Imaging of Atherosclerotic Plaques
Stroke is a major cause of death and disability worldwide. Stenotic carotid arteries can lead to stroke if the cause of the stenosis is a vulnerable atherosclerotic plaque.
- Trial name
- NCT04237064
- Testing
- Photoacoustic imaging
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Marc van Sambeek
Hemorrhagic Stroke
Precision Clinical and Genetic Tools for Brain Health in Hemorrhagic Stroke
The overall goal of this study is to increase health care provider awareness for common risk factors and comorbidities in patients with hemorrhagic stroke that are related to impaired brain health, to ultimately improve patients…
- Trial name
- NCT05643001
- Testing
- In-patient and out-patient electronic health record alert
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Massachusetts General Hospital
Acute Ischemic Stroke
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
The goal of this clinical trial is to learn if AB126, an investigational treatment made from neural exosomes, is safe and well tolerated when given to adults with moderate to severe acute ischemic stroke (AIS) who have undergone…
- Trial name
- NEXIS (NCT07813130)
- Testing
- AB126 Neural Exosomes Intravenous Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aruna Bio, Inc.
Stroke, Acute, Stroke, Complication
Feasibility of Stroke Screening Tools in Cardiac Surgery Patients
Patients undergoing cardiac surgery have a higher risk of postoperative stroke than patients undergoing non-cardiac surgery. Our ability to detect postoperative stroke in this population lags behind other postoperative…
- Conditions
- Stroke, Acute, Stroke, Complication, Surgical Complication
- Trial name
- PESST-Cardiac (NCT05447728)
- Testing
- Modified National Institutes of Health Stroke Scale, PRESTO
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
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