Clinical trials: Ventricular Fibrillation
Chronic Total Occlusion of Coronary Artery
Incidence of Ventricular Arrhythmias in Patients With Chronic Total Occlusion Recanalization
A chronic total occlusion (CTO) is common in patients with coronary artery disease. CTO recanalization has been shown to improve survival in comparison to failed CTO recanalization.
- Trial name
- VACTOR (NCT03475888)
- Testing
- Medtronic Reveal LINQ™ Insertable Cardiac Monitor (ICM)
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Obstructive Sleep Apnea, Premature Ventricular Contraction (PVC)
Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation
Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or…
- Conditions
- Obstructive Sleep Apnea, Premature Ventricular Contraction (PVC), Atrial Fibrillation (AF), Premature Atrial Contraction
- Trial name
- DISCRETE AF (NCT07220525)
- Testing
- HGNS Use Randomized Instructions
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Heart Failure, Block, Heart
Left Bundle Branch Area Pacing or Biventricular Pacing in AF and Left Ventricular Dysfunction
It is unknown whether left bundle branch area pacing (LBBAP) or biventricular pacing best prevents or reverses left ventricular (LV) adverse remodelling in patients with atrial fibrillation (AF) who require ventricular pacing or…
- Conditions
- Heart Failure, Block, Heart, Pacing-Induced Cardiomyopathy
- Trial name
- NCT06620705
- Testing
- Left bundle branch area pacing, Biventricular pacing
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 34 people
- Sponsor
- srdpiers
Heart Failure, Atrial Fibrillation
Mascot Study: Management of Atrial Fibrillation (AF) Suppression in AF-Heart Failure (HF) COmorbidity Therapy
The purpose of this study is to evaluate whether adding AF Suppression™ to cardiac resynchronization therapy (CRT) improves the prognosis of heart failure patients benefiting from cardiac resynchronization therapy.
- Conditions
- Heart Failure, Atrial Fibrillation, Ventricular Dysfunction
- Trial name
- MASCOT (NCT00187252)
- Testing
- Atrial Overdrive Pacing
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3
This is a multi-national, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of etripamil NS in patients with atrial fibrillation (AF).
- Trial name
- ReVeRA-301 (NCT06716021)
- Testing
- Etripamil
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 750 people
- Sponsor
- Milestone Pharmaceuticals Inc.
Ventricular Tachycardia, Ventricular Fibrillation, Heart Failure
Cognis and Teligen 100 HE and Reliance Quadripolar Defibrillation Lead (4-Site) Field Following
The COGENT-4 Field Following Study will evaluate the clinical performance of the Boston Scientific TELIGEN 100 HE Implantable Cardioverter Defibrillator (ICD), the COGNIS 100 HE Cardiac Resynchronization Therapy ICD (CRT-D)…
- Trial name
- Cogent-4 (NCT00606710)
- Testing
- Cognis 100-D, Teligen DR, VR 100 HE
- Where
- 4 sites in Denmark, Israel
- Volunteers
- 450 people
- Sponsor
- Guidant Corporation
Ventricular Tachycardia, Ventricular Fibrillation
DAVID II (Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial II)
The DAVID II Clinical Study evaluates the hypothesis that, in patients needing an ICD but without overt indications for pacing, AAI pacing with maximal concomitant drug therapy will not increase the rate of the combined endpoint…
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death, Congestive Heart Failure
- Trial name
- DAVIDII (NCT00187187)
- Testing
- Implantable Defibrillator (ICD)
- Volunteers
- 600 people
- Sponsor
- Abbott Medical Devices
Ventricular Tachycardia, Ventricular Fibrillation
MAVRIC VR ICD Registry
The purpose of this registry is to collect information on the health status of patients receiving Marquis/Maximo VR Implantable Cardiac Defibrillators (ICDs), how the devices are being programmed and how this correlates to…
- Trial name
- NCT00270933
- Testing
- Registry
- Where
- 91 sites in United States, Canada
- Volunteers
- 742 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation
Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response
The goal of this clinical trial is to compare in atrial fibrillation patient with rapid ventricular response. The main question it aims to answer are Effectiveness of Repeated Amiodarone dosing regimen versus standard dosing…
- Trial name
- NCT06262932
- Testing
- Amiodarone
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Police General Hospital, Thailand
Ventricular Fibrillation, Ventricular Arrythmia
Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.
This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with unexplained polymorphic ventricular tachycardia (VT) and/or ventricular fibrillation (VF), in patients with specific…
- Conditions
- Ventricular Fibrillation, Ventricular Arrythmia, Polymorphic Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- VIGILANCE (NCT03963271)
- Testing
- ECG-Imaging
- Where
- 3 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Sinus Node Disease, Atrioventricular; Block, Second Degree (Types I and II)
Physiological Ventricular Pacing Vs Managed Ventricular Pacing for Persistent AF Prevention in Prolonged AV Interval
A multicenter, prospective, randomized study in a 1:1 ratio, single-blind with double-blind evaluation to evaluate the superiority of physiological ventricular pacing (proposed modality) vs.
- Trial name
- PhysioVP-AF (NCT05367037)
- Testing
- PhysioVP, DDD-VPA
- Where
- Italy
- Volunteers
- 640 people
- Sponsor
- Quovadis Associazione
Myocardial Infarction, Ventricular Tachycardia
Risk Stratification of VT / VF After Myocardial Infarction Based on Cardiac MRI 2
Implantable cardioverter-defibrillators (ICD) are currently recommended (ESC guidelines 2015) for the primary prevention of sudden cardiac death (SCD) in patients with a remote myocardial infarction (MI) and a low (≤35%) left…
- Conditions
- Myocardial Infarction, Ventricular Tachycardia, Ventricular Fibrillation
- Trial name
- TVScreen-2 (NCT05226234)
- Testing
- MRI
- Where
- France
- Volunteers
- 275 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
Advanced Reperfusion Strategies for Refractory Cardiac Arrest
This is a Phase II, single center (Under the Center for Resuscitation Medicine at the University of Minnesota Medical School), partially blinded, prospective, intention to treat, safety and efficacy clinical trial, randomizing…
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia
- Trial name
- ARREST (NCT03880565)
- Testing
- Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Ventricular Tachycardia, Ventricular Fibrillation
Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection.
Efficacy and safety evaluation of amiodarone and Nifekalant hydrochloride(NIF) for the treatment of ventricular tachycardia and ventricular fibrillation.
- Trial name
- NCT03855826
- Testing
- Nifekalant hydrochloride, Amiodarone
- Where
- China
- Volunteers
- 756 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators
This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia, Ischemic Cardiomyopathy
- Trial name
- NCT07795892
- Testing
- Circulating Small RNA Profiling
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- University of Rzeszow
Congestive Heart Failure, Left Ventricular Failure
Catheter Ablation vs. Medical Therapy in Congested Hearts With AF
This study is a multi-center, randomized, unblinded, clinical trial. The objective is to determine if catheter-based atrial fibrillation (AF) ablation is superior to medical treatment in patients with impaired left ventricular…
- Conditions
- Congestive Heart Failure, Left Ventricular Failure, Atrial Fibrillation
- Trial name
- CATCH-AF (NCT02686749)
- Testing
- Catheter Ablation, FDA approved anti arrhythmic drug
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- The Cleveland Clinic
Arrhythmia, Cardiovascular Diseases
Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM)
To determine whether electrophysiologic study (EPS) or Holter monitoring (HM) was the better method for selecting effective long-term antiarrhythmic drug therapy in patients with sustained ventricular tachycardia, ventricular…
- Conditions
- Arrhythmia, Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Diseases
- Trial name
- NCT00000518
- Testing
- electrophysiology, electrocardiography, ambulatory, imipramine
- Sponsor
- University of Utah
Ventricular Tachycardia, Ventricular Fibrillation
Unpinning Termination Therapy for VT/VF
This study is intended to develop a better method for stopping potentially lethal heart rhythms than currently available defibrillators.
- Trial name
- NCT03871231
- Testing
- Unpinning Termination Therapy
- Where
- 4 sites in Australia
- Volunteers
- 8 people
- Sponsor
- Cardialen, Inc.
Permanent Atrial Fibrillation
Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF)
Atrial fibrillation is a common heart rhythm disturbance, causing important discomfort for patients, a high risk of stroke, frequent hospital admissions and a two-fold increase in death.
- Trial name
- RATE-AF (NCT02391337)
- Testing
- Bisoprolol, Digoxin
- Where
- 2 sites in United Kingdom
- Volunteers
- 161 people
- Sponsor
- University of Birmingham
Atrial Fibrillation
Study to Investigate the Effect of the A1 Agonist Capadenoson on Ventricular HR in Patients With Persistent or Permanent Atrial Fibrillation.
This trial has the primary goal to show that BAY68-4986 can lower the ventricular rate in patients with the indication persistent atrial fibrillation.
- Trial name
- NCT00568945
- Testing
- Capadenoson (BAY68-4986)
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Bayer