Clinical trials: Ventilatory Failure
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Nasal High Flow Therapy, Intensive Care Unit
High Flow Therapy in ICUs Across Ibero America
The study aims to describe the use of Nasal High Flow (NHF) in the intensive care units of participating centers in Iberoamerica.
- Conditions
- Nasal High Flow Therapy, Intensive Care Unit, Ventilatory Failure, Hypoxia
- Trial name
- T-Calfi (NCT03364946)
- Testing
- No intervention
- Where
- 9 sites in Colombia, Dominican Republic and 2 more
- Volunteers
- 255 people
- Sponsor
- Fundación Santa Fe de Bogota
Neuromuscular Diseases, Alveolar Hypoventilation
Impact of the Type of Interface in Neuromuscular Patients Treated With Nocturnal Noninvasive Ventilation
Nocturnal Non Invasive Ventilation (NIV) is the reference treatment for chronic alveolar hypoventilation in patients with neuro-muscular diseases.
- Trial name
- InterfaceNMD (NCT03458507)
- Testing
- Switch of nocturnal NIV interface
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Acute Respiratory Failure
NAVA Unloading - Effects on Distribution of Ventilation
Title: Reduced Unloading in NAVA Improves distribution of Ventilation in ICU patients. Objectives: 1. To investigate if NAVA targeted to moderate respiratory muscular unloading results in redistribution of ventilation to the…
- Trial name
- NCT02711722
- Testing
- Neurally adjusted ventilatory assist, PScli1, PScli2
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska University Hospital
Type 2 Respiratory Failure
BIPAP vs CPAP Effects on Type 2 Respiratory Failure Patients
Effectiveness of BIPAP is evaluated in Type-2 failure but evaluation of effectiveness of CPAP in Type-2 respiratory failure in post cardiac surgery patients was not done.
- Trial name
- NCT04020627
- Testing
- BiPAP Group, CPAP Group
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Respiratory Failure
Use of Neurally Adjusted Ventilatory Assist in Infants Respiratory Failure
The present protocol will demonstrate the feasibility and efficacy of a newly developed mode of mechanical ventilation, Neurally Adjusted Ventilatory Assist, commonly known as NAVA.
- Trial name
- NAVA (NCT00603174)
- Testing
- neurally adjusted ventilatory assist (NAVA)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- St. Justine's Hospital
Hypoventilation
Respiratory Consequences of N95-type Mask Usage in Pregnant Healthcare Workers - A Controlled Clinical Study
The study aims to find out if usage of N95 type respirators affects respiratory parameters in pregnant women so as to provide guidance on N95 respirator usage in pregnant healthcare workers.
- Trial name
- NCT02265926
- Testing
- N95 mask
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Health System, Singapore
Acute Respiratory Failure
NIV NAVA Versus NIV-PS in Pediatric Patients - Pilot Study
This pilot study will be an observational no randomize study in which the NiNAVAped protocol will be applied solely to the NIV NAVA arm.
- Trial name
- NINAVAPed (NCT01873261)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario La Paz
Hypercapnic Respiratory Failure, COPD, ARDS
Feasibility Study of the Hemolung Respiratory Assist System (Germany)
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System (RAS) in patients with hypercapnic respiratory failure.
- Trial name
- NCT01021605
- Testing
- Hemolung Respiratory Assist System
- Where
- 7 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Alung Technologies
Respiratory Insufficiency, Respiratory Failure
Safety and Performance of NivolisMonitor and NivolisAnton for Monitoring Patients on Ventilatory Assistance at Home
NivolisMonitor and NivolisAnton are new devices developed by Vivardis. NivolisMonitor is a generic and autonomous device for remote monitoring of ventilatory parameters generated by ventilatory assistance systems.
- Conditions
- Respiratory Insufficiency, Respiratory Failure, Home Monitoring
- Trial name
- NCT05698602
- Testing
- NivolisMonitor, NivolisAnton
- Where
- France
- Volunteers
- 10 people
- Sponsor
- VIVARDIS
Acute Hypercapnic Respiratory Failure
Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure
The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.
- Trial name
- NCT06108284
- Testing
- Intervention Arm (Biphasic cuirass ventilation)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Acute Respiratory Failure
NAVASET: Nava Level Titration Using Comfort Scales
Determining the optimal Neurally Adjusted Ventilatory Assist (NAVA) level remains challenging, and several methods have been suggested. However none of them seems easily utilisable.
- Trial name
- NCT02133443
- Testing
- PSV - pressure support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Pain
The Role of Opioidergic Systems in Breathing Based Analgesia
The purpose of this psychophysical and pharmacologic study is to determine if slow-breathing induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the opioid antagonist naloxone…
- Trial name
- NCT03419858
- Testing
- Mindfulness Meditation, Slow-Breathing, Naloxone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Sleep Disorder; Breathing-Related, Central Apnea
Transcutaneous CO2 Monitoring at Home for Children With Neuromuscular Disease
There is an unmet demand for the evaluation of nocturnal hypoventilation in children with NMD. An ambulatory screening tool that can reliably facilitate timely diagnosis and treatment in these children would be invaluable.
- Conditions
- Sleep Disorder; Breathing-Related, Central Apnea, Neuromuscular Diseases, Obstructive Sleep Apnea
- Trial name
- NCT03478566
- Testing
- Transcutaneous CO2 monitoring
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- The Hospital for Sick Children
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation
This study will evaluate whether adding extracorporeal carbon dioxide removal (ECCO2R) to noninvasive ventilation can improve breathing in adults hospitalized with a severe worsening of chronic obstructive pulmonary disease…
- Trial name
- NCT07785375
- Testing
- Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Hypercapnic Respiratory Failure, Sleep Disordered Breathing
Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation
Patients are invited to participate in a trial to test a new way to optimise long-term use of non-invasive ventilation using remote monitoring.
- Conditions
- Hypercapnic Respiratory Failure, Sleep Disordered Breathing, COPD, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- READ-NIV (NCT04884165)
- Testing
- Remote monitoring of home mechanical ventilation (NIV) using SRETT, Home mechanical ventilation (NIV) without remote monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Extubation Failure, Bronchopulmonary Dysplasia
The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0/7-28 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted…
- Conditions
- Extubation Failure, Bronchopulmonary Dysplasia, Death
- Trial name
- DIVA (NCT05446272)
- Testing
- NIV-NAVA, NS-NIPPV
- Where
- 20 sites in United States, Canada
- Volunteers
- 478 people
- Sponsor
- University of Pennsylvania
Respiratory Failure, Cardiac Failure
Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects on Cardiac Performance
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assist to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT00647361
- Testing
- Neurally adjusted ventilatory assist (NAVA) provided by a commercially available mechanical ventilator (Servo i, Maquet Critical Care, Solna, Sweden).
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Congenital Central Hypoventilation Syndrome
International Congenital Central Hypoventilation Syndrome (CCHS) Registry and CCHS SHARE
The Center for Autonomic Medicine in Pediatrics (CAMP), in collaboration with leading CCHS clinicians, scientists, and patient advocacy groups around the world has built the first International CCHS (Congenital Central…
- Trial name
- NCT03088020
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin