Clinical trials: Ventilation Therapy; Complications, open to volunteers
Respiratory Distress Syndrome, Newborn, Premature Birth
Prophylactic Minimally Invasive Surfactant Evaluation
The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation…
- Trial name
- PreProMISe (NCT06007547)
- Testing
- Poractant Alfa
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal)
Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS).
- Conditions
- Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn
- Trial name
- NCT07550218
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Ventilation Therapy; Complications
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to…
- Trial name
- BATMAN (NCT06142773)
- Testing
- Tidal Volume set on ventilator
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Postoperative Period, Physical Therapy Modalities
Positive Pressure Therapy to Optimize LUNG Function After Heart Surgery
The most common cardiac surgeries are myocardial revascularization and valve replacement or plastic surgery. In the postoperative period of cardiac surgeries, the incidence of pulmonary complications ranges from 30% to 50% and is…
- Conditions
- Postoperative Period, Physical Therapy Modalities, Continuous Positive Airway Pressure, Respiratory Function Tests
- Trial name
- PRO-LUNGHS (NCT06611527)
- Testing
- PS+PEEP group, CPAP group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Federal University of São Paulo
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury
Clinical Decision Support Tool in PARDS Pilot Study
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation.
- Conditions
- Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
- Trial name
- NCT04068012
- Testing
- Ventilator protocol
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Children's Hospital Los Angeles
Premature Infant, Ventilation Therapy
High Flow Nasal Cannula for Stabilization of Extremely Premature Infants
A prospective observational study evaluates the safety and efficacy of using High-Flow Nasal Cannula to stabilize extremely preterm infants immediately after birth.
- Conditions
- Premature Infant, Ventilation Therapy, High Flow Nasal Canula
- Trial name
- SIMPLSAFE2 (NCT06683677)
- Testing
- High-Flow Nasal Cannula
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Invasive Mechanical Ventilation, Severe Respiratory Distress Syndrome
Little Lungs Study
This clinical trial is being done to evaluate the safety and clinical response of late surfactant treatment with budesonide in extremely preterm infants requiring mechanical ventilation at 7-14 days of age.
- Trial name
- NCT06855043
- Testing
- Calfactant, Budesonide
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Respiratory Distress Syndrome in Premature Infant
Surfactant Therapy Via Supraglottic Airway to Preterm Neonates With RDS in Vietnam
Preterm babies often have trouble breathing because their lungs are not fully developed. This condition is called respiratory distress syndrome (RDS). A medicine called surfactant helps their lungs open up and work better.
- Trial name
- NEOSURF (NCT07098910)
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airways (SALSA), Intubation - Surfactant administration - Extubation (INSURE)
- Where
- Vietnam
- Volunteers
- 440 people
- Sponsor
- Karolinska Institutet
Lung Neoplasms, Thoracic Surgery Lung
Telerehabilitation Exercise Program for Postoperative Recovery in Lung Cancer.
Lung cancer is one of the leading causes of cancer-related morbidity and mortality worldwide. Thoracic surgery remains the treatment of choice for patients with early-stage disease; however, postoperative recovery is frequently…
- Trial name
- TEPUL (NCT07861282)
- Testing
- Therapeutic Exercise-Based Telerehabilitation, Usual Postoperative Care
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Seville
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Surgical Stress Response, Stress Physiological
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients.
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological
- Trial name
- NCT07464860
- Testing
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Cesarean Section, Cesarean Section Pain
Effects of Music Therapy, Breathing Exercises, and Virtual Reality on Obstetric Recovery, Pain, and Gastrointestinal Symptoms After Cesarean Section
Cesarean section is a common surgical procedure performed to deliver a baby when vaginal birth may pose risks to the mother or infant.
- Conditions
- Cesarean Section, Cesarean Section Pain, Obstetric Recovery, Gastrointestinal Symptoms
- Trial name
- NCT07551401
- Testing
- Music Therapy, Breathing Exercises, Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Selcuk University
Spontaneous Subarachnoid Hemorrhage
Baricitinib for the Lung Injury Following Spontaneous SAH
The present study is a randomized, parallel control, and double-blind trial designed to assess the efficacy of baricitinib in reducing the occurrence of pulmonary complications in patients with spontaneous subarachnoid hemorrhage…
- Trial name
- BLISS (NCT06439615)
- Testing
- Baricitinib 4 MG, Standard treatment
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Prematurity, Respiratory Disease
Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and…
- Conditions
- Prematurity, Respiratory Disease, Ventilator Lung; Newborn
- Trial name
- CAT/LPT (NCT06026163)
- Testing
- Caffeine citrate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 134 people
- Sponsor
- Ministry of Health, Saudi Arabia
Ventilation Therapy; Complications
Comparing Different Startegies of Positive Pressure Ventilation in Children
The most basic modes of mechanical ventilation are volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV).
- Trial name
- NCT06612125
- Testing
- volume controlled ventilation, pressure controlled ventilation, pressure controlled volume grantanteed ventilation
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Respiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS)
Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome
Respiratory distress syndrome (RDS) is a common cause of respiratory failure in preterm infants and is frequently treated with surfactant therapy.
- Conditions
- Respiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS), Surfactant
- Trial name
- NCT07350018
- Testing
- Poractant alfa, Calfactant
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 234 people
- Sponsor
- Uludag University