Clinical trials: Ventilation Therapy; Complications
Abdominal Sepsis, Acute Respiratory Failure
Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis.
- Conditions
- Abdominal Sepsis, Acute Respiratory Failure, Ventilation Therapy; Complications, Emergencies
- Trial name
- CHESTOMY (NCT05726500)
- Testing
- Arterial blood gas analysis, Venous blood gas analysis, Esophageal pressure monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Tumor of Lung Parenchyma, Complication of Ventilation Therapy
Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery
A safe and effective surgical environment is important for nonintubated thoracoscopic surgery. The investigators hypothesize that mini-dose succinylcholine can induce ultra-short period of apnea, by which the ventilatory…
- Conditions
- Tumor of Lung Parenchyma, Complication of Ventilation Therapy, Atelectasis
- Trial name
- NCT03469323
- Testing
- Succinylcholine
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Premature Birth
Follow-Up at 6 Years of a Cohort of Children Born Very Prematurely
Utilization of nitric oxide (NO) therapy has been related to a trend towards short term improvement in very premature infants. A two year follow-up of children treated soon after birth with NO in the neonatal period, suggests…
- Trial name
- NCT00390065
- Testing
- Nitric Oxide
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- Maternite Regionale Universitaire
Lung Neoplasms, Thoracic Surgery Lung
Telerehabilitation Exercise Program for Postoperative Recovery in Lung Cancer.
Lung cancer is one of the leading causes of cancer-related morbidity and mortality worldwide. Thoracic surgery remains the treatment of choice for patients with early-stage disease; however, postoperative recovery is frequently…
- Trial name
- TEPUL (NCT07861282)
- Testing
- Therapeutic Exercise-Based Telerehabilitation, Usual Postoperative Care
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Seville
Well-Being, Psychological
Protective Anesthesiological Management Procedure Imposes Control on Respiratory Comlications
Anesthetic effects, surgery, and invasive mechanical intubation can impair respiratory function during general anesthesia. The risk factors for postoperative pulmonary complications (PPCs) include the type of surgery and…
- Trial name
- NCT06282003
- Testing
- The procedure of protective lung ventilation
- Where
- Croatia
- Volunteers
- 53 people
- Sponsor
- Masa Kontic
Pleural Effusion
Positive Airway Pressure on Pleural Effusion After Drainage
The purpose of this study is to determine if the addition of intermittent positive airway pressure breathing (specific lung expansion technique) to conventional chest physiotherapy chest drainage is effective to accelerate the…
- Trial name
- NCT02246946
- Testing
- Positive Airway Pressure, Conventional Chest Physiotherapy, Control group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Universidade Cidade de Sao Paulo
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Postoperative Complications, Rehabilitation
Pulmonary Expansion Device in Tracheostomized Patients Therapies in Tracheostomized Patients
The goal of this clinical trial is to evaluate the safety and efficacy of using PED (Pulmonary Expansion Device) in tracheostomized patients requiring lung reexpansion therapy within a single institution.
- Conditions
- Postoperative Complications, Rehabilitation, Postoperative Care
- Trial name
- PEDTRAQ (NCT06075381)
- Testing
- Pulmonary Expansion Device (PED), Conventional management
- Volunteers
- 50 people
- Sponsor
- Fundacion Clinica Valle del Lili
Neonatology, Perinatal Distress Syndrome
Evaluation of Semi-rigid and Flexible Catheters for Less Invasive Surfactant Administration in Preterm Infants
The overall aim of this study is to determine the differences between two surfactant administration catheters in preterm infants.
- Trial name
- NCT05024435
- Testing
- Surfactant Administration
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Salzburger Landeskliniken
Hyaline Membrane Disease, Transient Tachypnea
Antenatal Corticoid Therapy for Late Preterm Babies
This study aims to determine the effectiveness of antenatal corticosteroid therapy in late preterm babies. The investigators hypothesis is corticoid accelerates fetal lung maturation even after 34 weeks and reduces risk of…
- Trial name
- ACTLPT (NCT00675246)
- Testing
- Betamethasone
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Mechanical Ventilation Complication, Muscle Weakness Condition
Effects of NMES in Critically Ill Patients
Muscle wasting occurred early and rapidly in critically ill patients. Early therapeutic strategies to either maintain muscle structure and function should be encouraged.
- Conditions
- Mechanical Ventilation Complication, Muscle Weakness Condition, Covid19
- Trial name
- NUMBERNMES (NCT04382378)
- Testing
- neuromuscular electrical stimulation
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Escola Superior de Ciencias da Saude
Ventilation Therapy; Complications
Physiological Dead Space Measured by Volumetric Capnography in BiPAP and APRV .
Background and Rationale : Mechanical ventilation is an essential component of the care of patients with respiratory failure.Biphasic positive Airway Pressure (BiPAP) and Airway Pressure release ventilation (APRV) are relatively…
- Trial name
- NCT03218943
- Testing
- APRV ventilation mode, BIPAP ventilation moood
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Ventilation Therapy; Complications
Correlation Between Muscle Thickness and Inflammation With Ventilator Use in Critically Ill Patients
Decrease thickness of diaphragm muscle, cross-sectional area of rectus femoris and biceps brachii muscle, and increase in CRP would affect ventilator length of use in critically ill patients in ICU
- Trial name
- NCT03933332
- Testing
- Diaphragm thickness, Cross-sectional area of rectus femoris muscle, Cross-sectional area of biceps brachii
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Kidney Failure, Respiratory Failure
Observational Study of Blood Pressure Measurements and Continuous Dialysis
Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing…
- Conditions
- Kidney Failure, Respiratory Failure, Critical Illness, Shock
- Trial name
- NCT01286506
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Chicago
Sleep Apnea, Obstructive, Pre-Eclampsia
Screening and Treatment of Obstructive Sleep Apnea in High-risk Pregnancy
This is an open-label multicenter randomized-controlled trial in 3 tertiary care hospitals including Ramathibodi Hospital, Phramongkutklao Hospital and Rajavithi Hospital.
- Conditions
- Sleep Apnea, Obstructive, Pre-Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03356106
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 3 sites in Thailand
- Volunteers
- 340 people
- Sponsor
- Ramathibodi Hospital
Meconium Aspiration Syndrome, Surfactant Dysfunction
Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome
The objective of the study is to compare the total duration of respiratory support in term neonates (≥37weeks) with meconium aspiration syndrome, who are provided early(≤2hr) bolus surfactant therapy versus standard care.
- Trial name
- NCT06090981
- Testing
- Bovine surfactant
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Lady Hardinge Medical College
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Surgical Stress Response, Stress Physiological
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients.
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological
- Trial name
- NCT07464860
- Testing
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Apnea, Ventilation Therapy; Complications
THRIVE Apneic Ventilation With Standardized Airway Management During General Anesthesia.
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) denotes the use of high-flow humidified nasal oxygen system (for example Optiflow®) as an alternative ventilation modality for an anesthetized patient without…
- Conditions
- Apnea, Ventilation Therapy; Complications, Respiratory Acidosis
- Trial name
- NCT03797859
- Testing
- Apneic ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation
NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients
Patients requiring prolonged time on the ventilator are susceptible to a wide range of clinical complications and excess mortality. It is therefore imperative for them to wean at the earliest possible time.
- Conditions
- Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation, Muscle Weakness
- Trial name
- NCT03453944
- Testing
- VentFree prototype (VF03-K) active stimulation
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Nijmegen