Clinical trials: Vegetative State
Disorder of Consciousness
Treating Severe Brain-injured Patients With Apomorphine
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness. Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical options.
- Trial name
- NCT03623828
- Testing
- Apomorphine Hydrochloride 50Mg/10mL Prefilled Syringe
- Where
- 2 sites in Belgium
- Volunteers
- 8 people
- Sponsor
- University of Liege
Vegetative State, Minimally Conscious State
Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State
Rationale. The investigators hypothesize that bilateral electrical central thalamic stimulation of patients in Vegetative State and Minimally Conscious State from at least 6 months could improve the level of responsiveness. Aims.
- Trial name
- CATS\ (NCT01027572)
- Testing
- Implantable neurostimulation system (Medtronic)
- Where
- 3 sites in Italy
- Volunteers
- 5 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Disorders of Consciousness, Severe Brain Injury
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT06851156
- Testing
- tTIS
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Acquired Brain Injury
Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain Injury
The prediction of the final neurological and functional status of patients with acquired brain injury remains very uncertain despite the findings of current medicine.
- Trial name
- NCT05968911
- Where
- Czechia
- Volunteers
- 211 people
- Sponsor
- Charles University, Czech Republic
Acquired Brain Injury, Development, Child
COgnitive REhabilitation in Pediatric Patients with ABI, from Vegetative State to Functional Recovery
Acquired brain injuries (ABI) represent one of the most important cause of disability and mortality during the pediatric age, also in the western Countries.
- Trial name
- COREABI (NCT04499092)
- Testing
- Personalized Neuropsychological treatment (CORE-ABI), Sequential Neuropsychological treatment (SET-ABI)
- Where
- Italy
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Vegetative State, Minimally Conscious State
Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal (DLPF) cortex transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- tDCS in DOC (NCT01673126)
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- University of Liege
Disorder of Consciousness, Vegetative State
Cerebellar iTBS in Patients With Disorders of Consciousness
Previous studies showed the excitatory effect of cerebellar transcranial magnetic stimulation(TMS) on motor cortex.Investigator evaluate the effects of bilateral cerebellar TMS on Coma Recovery Scale-Revised (CRS-R) scores in…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- CTPDOC (NCT05558930)
- Testing
- iTBS stimulation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness, Severe Brain Injury
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients, Vegetative State
- Trial name
- NCT04330547
- Testing
- Analgesic administration
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
Vegetative State, Minimally Conscious State
Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders. Notably, transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal cortex has proved…
- Conditions
- Vegetative State, Minimally Conscious State, Disorder of Consciousness
- Trial name
- NCT03823508
- Testing
- anodal tDCS
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University of Liege
Disorder of Consciousness, Minimally Conscious State
Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Cognitive Impairment
- Trial name
- STIMCOM (NCT03007784)
- Testing
- transcranial direct current stimulation (tDCS) / Comparison of current intensities
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Disorder of Consciousness, Minimally Conscious State
Diagnostic Accuracy of the Vegetative and Minimally Conscious State
The aim of this study was to investigate diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment
- Trial name
- NCT04139239
- Testing
- Coma Recovery Scale-revision
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hangzhou Normal University
Disorder of Consciousness, Minimally Conscious State
Temporal Interference Stimulation for Disorders of Consciousness
This study aims to investigate whether a new non-invasive brain stimulation technique, called temporal interference stimulation, can influence brain activity and potentially improve signs of consciousness in patients with severe…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Unresponsive Wakefulness Syndrome
- Trial name
- NCT07874178
- Testing
- Temporal Interference
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Minimally Conscious State, Vegetative State
The Initiation of Swallowing Can Indicate the Prognosis of DOC
This study is aimed to detect the initiation of swallowing act in DOC patients, to find if it is a good item as a stimulus and to detect the relationship between the initiation of swallowing act and the prognosis of DOC patients.
- Trial name
- NCT03508336
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Hangzhou Normal University
Chronic Disease
Resting Metabolic Rate in Chronic Bed-Ridden Patients
Research objective: to measure resting metabolic rate (REE) in long term, bed ridden, chronically ill patients and to compare their measured energy needs to standard REE equations
- Trial name
- RMR (NCT01069380)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Reuth Rehabilitation Hospital
Consciousness Disorder
Multimodal Neuroprognostication in Disorders of Consciousness
Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged.
- Trial name
- M-Neuro-DoC (NCT04534777)
- Testing
- repeated neurological, behavioral assessments and conventional, quantitative and functional brain imagery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Injury
A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness
This is a study to evaluate the safety and efficacy of the IBRF ACP/MCP intervention protocol in patients with severe disorders of consciousness (SDOC).
- Trial name
- NCT02696512
- Testing
- Polypharmacy using FDA-approved products, Median Nerve Stimulation (MNS), Nutraceutical Supplementation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- International Brain Research Foundation
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Behavioral Assessment of Nociception on NCS-R
The aim of this study was to investigate the relationship between behaviorally assessed consciousness levels and responsiveness to nociception in patients with disorders of consciousness (DOC)
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT04137497
- Testing
- The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hangzhou Normal University
Consciousness Disorders
Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)
The purpose of this study is to validate Russian version of Coma Recovery Scale - Revised and to assess its psychometric properties.
- Trial name
- NCT03060317
- Testing
- Examination with neurological scales.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Center of Neurology, Russia
Brain Diseases, Vegetative State
Chinese Validation of the Simplified Evaluation of CONsciousness Disorders（SECONDs）
The aim of this study was to translate the SECONDs from French into Chinese and assess the validity and reliability of the Chinese version of the SECONDs .
- Conditions
- Brain Diseases, Vegetative State, Unconsciousness, Central Nervous System Diseases
- Trial name
- NCT05496985
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Hangzhou Normal University