Clinical trials: Vasoconstriction
Psoriasis Vulgaris
A Vasoconstriction Study With LEO 90100
The purpose of this study is to compare the pharmacodynamic activity of LEO 90100 with Dermovate® cream, Dovobet® ointment, betamethasone dipropionate in LEO90100 vehicle, Synalar® ointment and LEO 90100 vehicle using a human…
- Trial name
- NCT01946386
- Testing
- LEO 90100 Aerosol, foam, Betamethasone dipropionate in LEO 90100 Aerosol, foam, vehicle, LEO 90100 Aerosol, foam, vehicle
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Esophageal Cancer, Lung Cancer
Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedures and One-Lung Ventilation
The purpose of this study is to evaluate the effects of Dexmedetomidine when used during thoracic surgery. The primary outcome will be changes in oxygenation as measured the PaO2 during one lung ventilation.
- Conditions
- Esophageal Cancer, Lung Cancer, Chest Wall Disorders
- Trial name
- Dex-One-Lung (NCT00839605)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Missouri-Columbia
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Vasodilation, Vasoconstriction
Vascular Function Improvements After Chronic Passive Stretching
Acutely, during different bouts of passive stretching (PS), blood flow (Q ̇) and shear rate ( ) in the feeding artery of the stretched muscles increases during the first two elongations and then it reduces during the following…
- Conditions
- Vasodilation, Vasoconstriction, Stretch, Sympathetic; Imbalance
- Trial name
- NCT04271241
- Testing
- Passive stretching (PS) training
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Milan
Vasoconstriction Disorder of Extremities
Response of the Autonomic Nervous System to Auricular Stimulation of the Vagus Nerve (x)
While invasive vagal stimulation has proven its therapeutic effectiveness over the past 20 years, particularly in the treatment of epilepsy or depression, its implementation is hampered by the high cost, high technicality and…
- Trial name
- AURIX (NCT04130893)
- Testing
- stimulation of G13 then G15, stimulation of G15 then G13
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Acute Pulmonary Embolism
Epoprostenol in Pulmonary Embolism
You are admitted to hospital because of pulmonary embolism. You are treated with anticoagulants. The investigators know that, despite this treatment, pulmonary embolism can be a threat especially if heart function is compromized.
- Trial name
- NCT01014156
- Testing
- epoprostenol
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Universitair Ziekenhuis Brussel
Vasoconstriction, Biomarkers
Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement
Medical and technological advancements allow increasingly complex invasive procedures to be performed on hospitalized patients, improving their survival rates and prognosis.
- Conditions
- Vasoconstriction, Biomarkers, Central Venous Catheters, Midline Catheter
- Trial name
- PICC (NCT07696156)
- Testing
- Immersive Virtual Reality, Peripherally Inserted Central Catheter (PICC), Mepivacaine 2% Injection
- Where
- 4 sites in Spain
- Volunteers
- 202 people
- Sponsor
- diana garcia
Reversible Cerebral Vasoconstriction Syndrome
RCVS: The Rational Approach to Diagnosis and Treatment
This is a randomized clinical trial of short-acting nimodipine versus twice daily extended release verapamil to treat patients presenting with Reversible Cerebral Vasoconstriction Syndrome (RCVS).
- Trial name
- NCT03150524
- Testing
- TCD- cerebral blood flow velocities, Headache pain score, Neurological examination
- Where
- 2 sites in United States
- Sponsor
- Johns Hopkins University
Vasodilation, Vasoconstriction
The Impact of Carbon Monoxide and Altitude on Vascular Function
The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes.
- Trial name
- CarMA (NCT04928183)
- Testing
- Carbon monoxide rebreathe, Sodium Nitroprusside, Phenylephrine Hydrochloride
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cardiovascular Effects
Diesel Exhaust and Vascular Function
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function.
- Trial name
- CVDTRAP4 (NCT01508637)
- Testing
- Diesel Exhaust, Filtered Air, Terazosin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Vasoconstriction, Healthy
Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
- Conditions
- Vasoconstriction, Healthy, Insulin Resistance
- Trial name
- NCT05244694
- Testing
- Insulin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cold Exposure
The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold
Individuals who operate in cold weather are at risk of developing cold injuries, for example, frostbite. They also often experience a loss of hand function and joint mobility due to a decrease in skin temperature and blood flow.
- Trial name
- NCT06784531
- Testing
- Mitoquinone mesylate (MitoQ), Cold Water Hand Immersion, Cold Air Exposure
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Imparied Retinal Vascular Reactivity, Healthy Subjects
Effect of Retaron® on Oxygen Induced Retinal Vasoconstriction in LPS Induced Inflammatory Model in Humans
Oxidative stress has been implicated to play a pathogenic role in many disease processes, especially in age-related disorders such as age-related macular degeneration.
- Trial name
- NCT02221089
- Testing
- Escherichia coli Endotoxin, Retaron®
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Epidural Block, Electrical Impedance Tomography
Epidural Block Impairs HPV During One-lung Ventilation: an EIT- Based Prospective Observation Study
Define the effect of epidural block on HPV by EIT.
- Trial name
- NCT04730089
- Testing
- Electrical impedance tomography
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Type 2 Diabetes Mellitus
Effect of DPP4 Inhibition on Vasoconstriction
The purpose of this study is to understand how dipeptidyl peptidase IV (DPP4) inhibition in diabetics affects hemodynamic parameters and sympathetic activation in the setting of increasing concentrations of neuropeptide Y, an…
- Trial name
- NCT02639637
- Testing
- Sitagliptin, Neuropeptide Y, Enalaprilat
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University
Hormone Therapy
Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans
1. to investigate the association between route of administration of exogenous estrogen (transdermal vs. oral) and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not…
- Trial name
- NCT05442463
- Testing
- Captopril Tablets, Iohexol
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy
Pivotal Bioequivalence Study of Topically Delivered Halobetasol Propionate Ointment in Normal Skin in Healthy Adult Subjects
The purpose of this study is to compare the vasoconstriction response profile and bioequivalence between one innovator lot of Ultravate® 0.05% ointment and one test/generic lot of Halobetasol propionate 0.05% ointment (Alpharma…
- Trial name
- NCT00865605
- Testing
- Halobetasol Propionate 0.05% Ointment, single exposure, Ultravate® 0.05% ointment, single exposure
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
One Lung Ventilation OLV, Esophageal Atresia
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.
The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be…
- Conditions
- One Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, Pneumonectomy
- Trial name
- RCT (NCT04932746)
- Testing
- Dexmedetomidine
- Where
- Syria
- Volunteers
- 110 people
- Sponsor
- Damascus University
Healthy Volunteers, Chuvash Polycythaemia
Study of the Effects of Commercial Air Travel on the Lungs
The study hypothesis is that commercial air travel causes an increase in the blood pressure in the lungs (pulmonary artery pressure) that can be clinically relevant.
- Trial name
- NCT01420224
- Testing
- Commercial airline flight
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Insulin Resistance, Healthy
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake.
- Conditions
- Insulin Resistance, Healthy, Obesity
- Trial name
- NCT03318094
- Testing
- Phentolamine, Saline, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center