Clinical trials: Vascular Malformations
Chronic Renal Failure
A Study of Cytokine and Inflammatory Markers in Patients With Chronic Renal Failure
We hope to study components within the blood that may predict success, failure or other associated complications in relation to the type of vascular access being used.
- Trial name
- NCT00565994
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Hereditary Haemorrhagic Telangiectasia (HHT)
Symptoms and Treatment Results in Hereditary Hemorrhagic Telangiectasia
Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder with recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations.
- Trial name
- NCT02690246
- Testing
- questionnaire
- Where
- Germany
- Volunteers
- 915 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Arteriovenous Malformation
Genetics of Arteriovenous Malformations
The goal of this study is to identify genetic alterations resulting in the development of arteriovenous malformation (AVM) in the central nervous system.
- Trial name
- NCT02445430
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
End-stage Kidney Disease, Diabetes Mellitus
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula
Background Arteriovenous (AV) fistula is the most common vascular access for long-term hemodialysis in the end-stage renal disease (ESRD) patients. About 25% of these patients are diabetes mellitus.
- Conditions
- End-stage Kidney Disease, Diabetes Mellitus, Arteriovenous Fistula
- Trial name
- NCT01863914
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Anomalies Vascular
Radifocus (Terumo) Versus Silverway (Asahi) to Deliver Catheters During Cardiac Catheterization
In some cases the standard J-tip guidewire cannot deliver the catheter into the aortic root, because of arterial loops or spasm.
- Trial name
- RADVES (NCT05231889)
- Testing
- Silverway guidewire, Radifocus guidewire
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Telangiectasia, Hereditary Hemorrhagic
Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia
We will address coagulation parameters in hereditary haemorrhagic telangiectasia (HHT) compared to controls.
- Trial name
- NCT00230659
- Testing
- Blood sample to be taken.
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Vascular Malformations
Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations
The low-flow malformations include venous and lymphatic malformations. The malformation often affects the skin and can extend deep to the muscles and bone, as well as to deep organs.
- Trial name
- MVFL (NCT03440827)
- Testing
- Focus Group
- Where
- 3 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Arteriovenous Fistula
Color Doppler Ultrasonography in Prediction of Arteriovenous Fistula Maturation in Hemodialysis Patients
The transplant is the definitive treatment of renal insufficiency, in our days. While waiting for it, the arteriovenous fistula surgery is standard procedure.
- Trial name
- NCT03171701
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
May-Thurner Syndrome, Iliac Venous Compression
Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI
The purpose of the study is to quantitatively characterize the flow in the pelvic venous structures using 2D and 4D flow MRI with the objective of establishing physiologic and pathologic parameters for downstream computational…
- Trial name
- NCT06888024
- Testing
- non-contrast enhanced abdomen and pelvis MRI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ningcheng Peter Li
Arteriovenous Malformation, Hemangioma
Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB
This is an open-label whole-body PET/CT study for investigation of radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and diagnostic performance of 68Ga-NEB in healthy volunteers and patients with suspected…
- Conditions
- Arteriovenous Malformation, Hemangioma, Neoplasms Lymph Nodes, Lymphedema
- Trial name
- NCT02496013
- Testing
- 68Ga-NEB
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cerebral Cavernous Malformation, Cavernous Angioma
Biomarkers of CASH
The project aims to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans.
- Conditions
- Cerebral Cavernous Malformation, Cavernous Angioma, Hemorrhagic Microangiopathy
- Trial name
- NCT04467489
- Testing
- observational
- Where
- 4 sites in United States
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- University of Chicago
End Stage Renal Disease, Arteriovenous Fistula
Role of Monocytes Adhesion and Vascular Lesions in Vascular Access Success or Failure in Uremic Patients
This study is designed to identify novel predictors of vascular access success or failure in chronic kidney disease patients. Despite efforts to improve placement of arteriovenous fistula (AVF) the primary failure rates are…
- Trial name
- ROMAVAS (NCT03231410)
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Hip Fracture of Intertrochanteric Type, Thromboembolic Event
Diffrence in Thromboprofilaksis in Elderly Ostoepenic Hip Fractures According to Mobility Status by Genetic Analysis
Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively…
- Conditions
- Hip Fracture of Intertrochanteric Type, Thromboembolic Event, Osteopenia, Thrombosis Embolism
- Trial name
- HSP 47 (NCT06959017)
- Testing
- Gene Expression Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Lymphangiomatosis, Lymphedema
Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
Background: Lymphatics are a type of vessel, similar to arteries and veins. Lymphatic disorders happen when these vessels don t work properly.
- Conditions
- Lymphangiomatosis, Lymphedema, Lymphangiectasia, Pulmonary Lymphangiectasia
- Trial name
- NCT02156115
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypothermia
Study of Heat and Intravenous Fluids for Exogenous Rewarming
The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with…
- Trial name
- SHIVER (NCT02339103)
- Testing
- Warmed IV fluids, Warmed perfusion pads
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stanford University
Capillary Malformation, Laser
Assessing the Effects of Air-cooling on Capillary Malformations
The purpose of this observational study is to ascertain the effects of cutaneous air cooling on vessel diameter within Capillary Malformations (CM).
- Conditions
- Capillary Malformation, Laser, Skin Cooling
- Trial name
- NCT01735734
- Testing
- Air cooling to CM site
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Health Service, United Kingdom
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Portopulmonary Hypertension, Pulmonary Arterial Hypertension (PAH)
Genetic Hallmarks of Patients With Congenital Portosystemic Shunts and Portopulmonary Hypertension
Congenital portosystemic shunt (CPSS) are rare vascular malformations causing blood from the intestines to bypass the liver and directly flow into body's general circulation.
- Conditions
- Portopulmonary Hypertension, Pulmonary Arterial Hypertension (PAH), Congenital Portosystemic Shunt
- Trial name
- Gen-PoPH-CPSS (NCT07314814)
- Testing
- targeted gene panels analysis, whole genome analysis
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Valérie Mc Lin
Brain Tumor, Brain Pathology
Can we Use Resting-state fMRI and CSD Fiber Tractography for Presurgical Mapping?
This prospective study aims to investigate and validate the use of resting-state functional MRI (rs-fMRI) and high angular resolution diffusion imaging (HARDI), specifically constrained spherical deconvolution (CSD) tractography…
- Conditions
- Brain Tumor, Brain Pathology, Epilepsy, Vascular Malformations, Brain
- Trial name
- NCT06040580
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Cerebrospinal Venous Insufficiency
Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI
This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.
- Trial name
- NCT01425554
- Testing
- Doppler sonography of internal jugular veins, Magnetic resonance venography of internal jugular veins, Air-plethysmography of the neck
- Where
- Poland
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Euromedic Specialist Clinics, Poland